Pseudomonas aeruginosa genotypes acquired by children with cystic fibrosis by age 5-years.

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dc.contributor.author Kidd, Timothy J
dc.contributor.author Ramsay, Kay A
dc.contributor.author Vidmar, Suzanna
dc.contributor.author Carlin, John B
dc.contributor.author Bell, Scott C
dc.contributor.author Wainwright, Claire E
dc.contributor.author Grimwood, Keith
dc.contributor.author ACFBAL Study Investigators
dc.coverage.spatial Netherlands
dc.date.accessioned 2022-06-13T23:21:08Z
dc.date.available 2022-06-13T23:21:08Z
dc.date.issued 2015-05
dc.identifier.citation (2015). Journal of Cystic Fibrosis, 14(3), 361-369.
dc.identifier.issn 1569-1993
dc.identifier.uri https://hdl.handle.net/2292/59816
dc.description.abstract <h4>Background</h4>We describe Pseudomonas aeruginosa acquisitions in children with cystic fibrosis (CF) aged ≤5-years, eradication treatment efficacy, and genotypic relationships between upper and lower airway isolates and strains from non-CF sources.<h4>Methods</h4>Of 168 CF children aged ≤5-years in a bronchoalveolar lavage (BAL)-directed therapy trial, 155 had detailed microbiological results. Overall, 201/271 (74%) P. aeruginosa isolates from BAL and oropharyngeal cultures were available for genotyping, including those collected before and after eradication therapy.<h4>Results</h4>Eighty-two (53%) subjects acquired P. aeruginosa, of which most were unique strains. Initial eradication success rate was 90%, but 36 (44%) reacquired P. aeruginosa, with genotypic substitutions more common in BAL (12/14) than oropharyngeal (3/11) cultures. Moreover, oropharyngeal cultures did not predict BAL genotypes reliably.<h4>Conclusions</h4>CF children acquire environmental P. aeruginosa strains frequently. However, discordance between BAL and oropharyngeal strains raises questions over upper airway reservoirs and how to best determine eradication in non-expectorating children.
dc.format.medium Print-Electronic
dc.language eng
dc.publisher Elsevier BV
dc.relation.ispartofseries Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society
dc.rights Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher.
dc.rights.uri https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm
dc.subject ACFBAL Study Investigators
dc.subject Oropharynx
dc.subject Bronchoalveolar Lavage Fluid
dc.subject Humans
dc.subject Pseudomonas aeruginosa
dc.subject Pseudomonas Infections
dc.subject Cystic Fibrosis
dc.subject DNA, Bacterial
dc.subject Anti-Bacterial Agents
dc.subject Retrospective Studies
dc.subject Follow-Up Studies
dc.subject Genotype
dc.subject Child, Preschool
dc.subject Infant
dc.subject Female
dc.subject Male
dc.subject Eradication
dc.subject Genotyping
dc.subject Infection
dc.subject Lung
dc.subject Pediatric
dc.subject Pediatric Research Initiative
dc.subject Clinical Research
dc.subject Rare Diseases
dc.subject Congenital
dc.subject Science & Technology
dc.subject Life Sciences & Biomedicine
dc.subject Respiratory System
dc.subject LAVAGE-DIRECTED THERAPY
dc.subject CHRONIC LUNG INFECTION
dc.subject YOUNG-CHILDREN
dc.subject BRONCHOALVEOLAR LAVAGE
dc.subject OROPHARYNGEAL CULTURES
dc.subject ERADICATION THERAPY
dc.subject DIAGNOSTIC-TOOL
dc.subject STRAINS
dc.subject INFANTS
dc.subject COLONIZATION
dc.subject 1102 Cardiorespiratory Medicine and Haematology
dc.subject Clinical
dc.subject Clinical Medicine and Science
dc.subject Congenital Disorders
dc.subject 1103 Clinical Sciences
dc.title Pseudomonas aeruginosa genotypes acquired by children with cystic fibrosis by age 5-years.
dc.type Journal Article
dc.identifier.doi 10.1016/j.jcf.2014.12.007
pubs.issue 3
pubs.begin-page 361
pubs.volume 14
dc.date.updated 2022-05-26T03:35:16Z
dc.rights.holder Copyright: The author en
dc.identifier.pmid 25563522 (pubmed)
pubs.author-url https://www.ncbi.nlm.nih.gov/pubmed/25563522
pubs.end-page 369
pubs.publication-status Published
dc.rights.accessrights http://purl.org/eprint/accessRights/RetrictedAccess en
pubs.subtype Research Support, Non-U.S. Gov't
pubs.subtype Multicenter Study
pubs.subtype Randomized Controlled Trial
pubs.subtype Journal Article
pubs.elements-id 531772
pubs.org-id Medical and Health Sciences
pubs.org-id School of Medicine
pubs.org-id Paediatrics Child & Youth Hlth
dc.identifier.eissn 1873-5010
dc.identifier.pii S1569-1993(14)00304-X
pubs.record-created-at-source-date 2022-05-26


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