The global impact of SARS-CoV-2 in 181 people with cystic fibrosis.

Show simple item record McClenaghan, Elliot Cosgriff, Rebecca Brownlee, Keith Ahern, Susannah Burgel, Pierre-Régis Byrnes, Catherine A Colombo, Carla Corvol, Harriet Cheng, Stephanie Y Daneau, Géraldine Elbert, Alexander Faro, Albert Goss, Christopher H Gulmans, Vincent Gutierrez, Hector de Monestrol, Isabelle Jung, Andreas Justus, Lutz Nährlich Kashirskaya, Nataliya Marshall, Bruce C McKone, Edward Middleton, Peter G Mondejar-Lopez, Pedro Pastor-Vivero, M Dolores Padoan, Rita Rizvi, Samar Ruseckaite, Rasa Salvatore, Marco Stephenson, Anne L Filho, Luiz Vicente R da Silva Melo, Joel Zampoli, Marco Carr, Siobhán B Global Registry Harmonization Group
dc.coverage.spatial Netherlands 2022-06-13T23:22:49Z 2022-06-13T23:22:49Z 2020-11-04
dc.identifier.citation (2020). Journal of Cystic Fibrosis, 19(6), 868-871.
dc.identifier.issn 1569-1993
dc.description.abstract With the growing SARS-CoV-2 pandemic, we need to better understand its impact in specific patient groups like those with Cystic Fibrosis (CF). We report on 181 people with CF (32 post-transplant) from 19 countries diagnosed with SARS-CoV-2 prior to 13 June 2020. Infection with SARS-CoV-2 appears to exhibit a similar spectrum of outcomes to that seen in the general population, with 11 people admitted to intensive care (7 post-transplant), and 7 deaths (3 post-transplant). A more severe clinical course may be associated with older age, CF-related diabetes, lower lung function in the year prior to infection, and having received an organ transplant. Whilst outcomes in this large cohort are better than initially feared overall, possibly due to a protective effect of the relatively younger age of the CF population compared to other chronic conditions, SARS-CoV-2 is not a benign disease for all people in this patient group.
dc.format.medium Print-Electronic
dc.language eng
dc.publisher Elsevier BV
dc.relation.ispartofseries Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society
dc.rights Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher.
dc.subject Global Registry Harmonization Group
dc.subject Lung
dc.subject Humans
dc.subject Cystic Fibrosis
dc.subject Tomography, X-Ray Computed
dc.subject Respiratory Function Tests
dc.subject Hospitalization
dc.subject Lung Transplantation
dc.subject Registries
dc.subject Mortality
dc.subject Risk Factors
dc.subject Age Factors
dc.subject Comorbidity
dc.subject Sex Factors
dc.subject Adult
dc.subject Aged
dc.subject Female
dc.subject Male
dc.subject Global Health
dc.subject Outcome Assessment, Health Care
dc.subject COVID-19
dc.subject SARS-CoV-2
dc.subject COVID-19 Testing
dc.subject Coronavirus
dc.subject Transplant
dc.subject Emerging Infectious Diseases
dc.subject Orphan Drug
dc.subject Clinical Research
dc.subject Rare Diseases
dc.subject Infectious Diseases
dc.subject Pneumonia & Influenza
dc.subject Prevention
dc.subject Transplantation
dc.subject Pneumonia
dc.subject 7.1 Individual care needs
dc.subject Infection
dc.subject Congenital
dc.subject Science & Technology
dc.subject Life Sciences & Biomedicine
dc.subject Respiratory System
dc.subject 1103 Clinical Sciences
dc.title The global impact of SARS-CoV-2 in 181 people with cystic fibrosis.
dc.type Journal Article
dc.identifier.doi 10.1016/j.jcf.2020.10.003
pubs.issue 6
pubs.begin-page 868
pubs.volume 19 2022-05-26T02:36:31Z
dc.rights.holder Copyright: The author en
dc.identifier.pmid 33183965 (pubmed)
pubs.end-page 871
pubs.publication-status Published
dc.rights.accessrights en
pubs.subtype brief-report
pubs.subtype Journal Article
pubs.elements-id 827376 Medical and Health Sciences School of Medicine Paediatrics Child & Youth Hlth
dc.identifier.eissn 1873-5010
dc.identifier.pii S1569-1993(20)30877-8
pubs.record-created-at-source-date 2022-05-26

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