dc.contributor.author |
Zhao, Shiting |
|
dc.contributor.author |
Chu, Yi |
|
dc.contributor.author |
Zhang, Yuwei |
|
dc.contributor.author |
Zhou, Yulai |
|
dc.contributor.author |
Jiang, Zhiwu |
|
dc.contributor.author |
Wang, Zhengqi |
|
dc.contributor.author |
Mao, Liufeng |
|
dc.contributor.author |
Li, Kuai |
|
dc.contributor.author |
Sun, Wei |
|
dc.contributor.author |
Li, Peng |
|
dc.contributor.author |
Jia, Shiqi |
|
dc.contributor.author |
Wang, Cunchuan |
|
dc.contributor.author |
Xu, Aimin |
|
dc.contributor.author |
Loomes, Kerry |
|
dc.contributor.author |
Tang, Shibing |
|
dc.contributor.author |
Wu, Donghai |
|
dc.contributor.author |
Hui, Xiaoyan |
|
dc.contributor.author |
Nie, Tao |
|
dc.coverage.spatial |
Netherlands |
|
dc.date.accessioned |
2022-06-14T01:13:44Z |
|
dc.date.available |
2022-06-14T01:13:44Z |
|
dc.date.issued |
2019-04 |
|
dc.identifier.citation |
(2019). Life Sciences, 222, 117-124. |
|
dc.identifier.issn |
0024-3205 |
|
dc.identifier.uri |
https://hdl.handle.net/2292/59836 |
|
dc.description.abstract |
Obesity is caused by energy imbalance and accompanied by adipocyte hypertrophy and hyperplasia. Therefore, both enhancement of adipocyte energy expenditure and inhibition of adipogenesis are viable ways to combat obesity. Using the Ucp1-2A-luciferase reporter animal model previously reported by us as a screening platform, a chemical compound Linifanib was identified as a potent inducer of UCP1 expression in primary inguinal adipocytes in vitro and in vivo. Signal pathway analyses showed that Linifanib promoted adipocyte browning by attenuating STAT3 phosphorylation. The effects of Linifanib on adipocyte browning were blocked by the compound, SD19, which activates the STAT3 signaling cascade. Linifanib also inhibited adipocyte differentiation, by blocking mitotic clonal expansion, which could be rescued by STAT3 activator. Taken together, our results indicate that Linifanib might serve as a potential drug for the treatment of obesity. |
|
dc.format.medium |
Print-Electronic |
|
dc.language |
eng |
|
dc.publisher |
Elsevier BV |
|
dc.relation.ispartofseries |
Life sciences |
|
dc.rights |
Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. |
|
dc.rights.uri |
https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm |
|
dc.rights.uri |
https://creativecommons.org/licenses/by-nc-nd/4.0/ |
|
dc.subject |
Cells, Cultured |
|
dc.subject |
3T3-L1 Cells |
|
dc.subject |
Animals |
|
dc.subject |
Mice, Transgenic |
|
dc.subject |
Smegmamorpha |
|
dc.subject |
Mice |
|
dc.subject |
Phenylurea Compounds |
|
dc.subject |
Indazoles |
|
dc.subject |
Anti-Obesity Agents |
|
dc.subject |
Random Allocation |
|
dc.subject |
Dose-Response Relationship, Drug |
|
dc.subject |
Adipogenesis |
|
dc.subject |
STAT3 Transcription Factor |
|
dc.subject |
Adipocytes, Brown |
|
dc.subject |
Browning |
|
dc.subject |
Linifanib |
|
dc.subject |
Obesity |
|
dc.subject |
STAT3 |
|
dc.subject |
Prevention |
|
dc.subject |
Diabetes |
|
dc.subject |
5.1 Pharmaceuticals |
|
dc.subject |
0601 Biochemistry and Cell Biology |
|
dc.subject |
Biomedical |
|
dc.subject |
Basic Science |
|
dc.subject |
1115 Pharmacology and Pharmaceutical Sciences |
|
dc.title |
Linifanib exerts dual anti-obesity effect by regulating adipocyte browning and formation. |
|
dc.type |
Journal Article |
|
dc.identifier.doi |
10.1016/j.lfs.2019.01.047 |
|
pubs.begin-page |
117 |
|
pubs.volume |
222 |
|
dc.date.updated |
2022-05-02T06:27:02Z |
|
dc.rights.holder |
Copyright: Elsevier BV |
en |
dc.identifier.pmid |
30708100 (pubmed) |
|
pubs.author-url |
https://www.ncbi.nlm.nih.gov/pubmed/30708100 |
|
pubs.end-page |
124 |
|
pubs.publication-status |
Published |
|
dc.rights.accessrights |
http://purl.org/eprint/accessRights/OpenAccess |
en |
pubs.subtype |
Journal Article |
|
pubs.elements-id |
765963 |
|
pubs.org-id |
Science |
|
pubs.org-id |
Biological Sciences |
|
pubs.org-id |
Science Research |
|
pubs.org-id |
Maurice Wilkins Centre (2010-2014) |
|
dc.identifier.eissn |
1879-0631 |
|
dc.identifier.pii |
S0024-3205(19)30060-8 |
|
pubs.record-created-at-source-date |
2022-05-02 |
|