Pancreas Fat, an Early Marker of Metabolic Risk? A Magnetic Resonance Study of Chinese and Caucasian Women: TOFI_Asia Study.

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dc.contributor.author Sequeira, Ivana R
dc.contributor.author Yip, Wilson C
dc.contributor.author Lu, Louise WW
dc.contributor.author Jiang, Yannan
dc.contributor.author Murphy, Rinki
dc.contributor.author Plank, Lindsay D
dc.contributor.author Cooper, Garth JS
dc.contributor.author Peters, Carl N
dc.contributor.author Lu, Jun
dc.contributor.author Hollingsworth, Kieren G
dc.contributor.author Poppitt, Sally D
dc.coverage.spatial Switzerland
dc.date.accessioned 2022-06-14T23:57:44Z
dc.date.available 2022-06-14T23:57:44Z
dc.date.issued 2022-01
dc.identifier.citation (2022). Frontiers in Physiology, 13, 819606-.
dc.identifier.issn 1664-042X
dc.identifier.uri https://hdl.handle.net/2292/59868
dc.description.abstract <h4>Objective</h4>Prevalence of type 2 diabetes (T2D) is disproportionately higher in younger outwardly lean Asian Chinese compared to matched Caucasians. Susceptibility to T2D is hypothesised due to dysfunctional adipose tissue expansion resulting in adverse abdominal visceral and organ fat accumulation. Impact on early risk, particularly in individuals characterised by the thin-on-the-outside-fat-on-the-inside (TOFI) phenotype, is undetermined.<h4>Methods</h4>Sixty-eight women [34 Chinese, 34 Caucasian; 18-70 years; body mass index (BMI), 20-45 kg/m<sup>2</sup>] from the TOFI_Asia study underwent magnetic resonance imaging and spectroscopy to quantify visceral, pancreas, and liver fat. Total body fat was (TBF) assessed by dual-energy x-ray absorptiometry, and fasting blood biomarkers were measured. Ethnic comparisons, conducted using two-sample tests and multivariate regressions adjusted for age, % TBF and ethnicity, identified relationships between abdominal ectopic fat depots with fasting plasma glucose (FPG), insulin resistance (HOMA2-IR), and related metabolic clinical risk markers in all, and within ethnic groups.<h4>Results</h4>Despite being younger and of lower bodyweight, Chinese women in the cohort had similar BMI and % TBF compared to their Caucasian counterparts. Protective high-density lipoprotein cholesterol, total- and high-molecular weight adiponectin were significantly lower, while glucoregulatory glucagon-like peptide-1 and glucagon significantly higher, in Chinese. There were no ethnic differences between % pancreas fat and % liver fat. However, at low BMI, % pancreas and % liver fat were ∼1 and ∼2% higher in Chinese compared to Caucasian women. In all women, % pancreas and visceral adipose tissue had the strongest correlation with FPG, independent of age and % TBF. Percentage (%) pancreas fat and age positively contributed to variance in FPG, whereas % TBF, amylin and C-peptide contributed to IR which was 0.3 units higher in Chinese.<h4>Conclusion</h4>Pancreas fat accumulation may be an early adverse event, in TOFI individuals, with peptides highlighting pancreatic dysfunction as drivers of T2D susceptibility. Follow-up is warranted to explore causality.
dc.format.medium Electronic-eCollection
dc.language eng
dc.publisher Frontiers Media SA
dc.relation.ispartofseries Frontiers in physiology
dc.rights Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher.
dc.rights.uri https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm
dc.rights.uri https://creativecommons.org/licenses/by/4.0/
dc.subject liver fat
dc.subject magnetic resonance imaging and spectroscopy
dc.subject pancreas fat
dc.subject type 2 diabetes
dc.subject visceral adipose tissue
dc.subject Prevention
dc.subject Liver Disease
dc.subject Clinical Research
dc.subject Digestive Diseases
dc.subject Obesity
dc.subject Nutrition
dc.subject Diabetes
dc.subject 2.1 Biological and endogenous factors
dc.subject Metabolic and endocrine
dc.subject Science & Technology
dc.subject Life Sciences & Biomedicine
dc.subject Physiology
dc.subject BETA-CELL FUNCTION
dc.subject INSULIN-SECRETION
dc.subject COMPUTED-TOMOGRAPHY
dc.subject LIVER
dc.subject ACCUMULATION
dc.subject STEATOSIS
dc.subject TISSUE
dc.subject INDIVIDUALS
dc.subject ADIPOSITY
dc.subject 0606 Physiology
dc.subject 1116 Medical Physiology
dc.subject 1701 Psychology
dc.title Pancreas Fat, an Early Marker of Metabolic Risk? A Magnetic Resonance Study of Chinese and Caucasian Women: TOFI_Asia Study.
dc.type Journal Article
dc.identifier.doi 10.3389/fphys.2022.819606
pubs.begin-page 819606
pubs.volume 13
dc.date.updated 2022-05-19T22:16:08Z
dc.rights.holder Copyright: The author en
dc.identifier.pmid 35431998 (pubmed)
pubs.author-url https://www.ncbi.nlm.nih.gov/pubmed/35431998
pubs.publication-status Published
dc.rights.accessrights http://purl.org/eprint/accessRights/OpenAccess en
pubs.subtype research-article
pubs.subtype Journal Article
pubs.elements-id 885678
pubs.org-id Medical and Health Sciences
pubs.org-id Science
pubs.org-id Biological Sciences
pubs.org-id Science Research
pubs.org-id Statistics
pubs.org-id School of Medicine
pubs.org-id Medicine Department
pubs.org-id Surgery Department
pubs.org-id Maurice Wilkins Centre (2010-2014)
dc.identifier.eissn 1664-042X
pubs.number ARTN 819606
pubs.record-created-at-source-date 2022-05-20
pubs.online-publication-date 2022-03-31


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