dc.contributor.author |
White, Joni Renee |
|
dc.contributor.author |
Dauros-Singorenko, Priscila |
|
dc.contributor.author |
Hong, Jiwon |
|
dc.contributor.author |
Vanholsbeeck, Frédérique |
|
dc.contributor.author |
Phillips, Anthony |
|
dc.contributor.author |
Swift, Simon |
|
dc.coverage.spatial |
England |
|
dc.date.accessioned |
2022-06-19T23:05:06Z |
|
dc.date.available |
2022-06-19T23:05:06Z |
|
dc.date.issued |
2021-04 |
|
dc.identifier.citation |
(2021). Biochemical Society Transactions, 49(2), 881-891. |
|
dc.identifier.issn |
0300-5127 |
|
dc.identifier.uri |
https://hdl.handle.net/2292/59998 |
|
dc.description.abstract |
Cells from all domains of life release extracellular vesicles (EVs), packages that carry a cargo of molecules that participate in communication, co-ordination of population behaviours, virulence and immune response mechanisms. Mammalian EVs play an increasingly recognised role to fight infection, yet may also be commandeered to disseminate pathogens and enhance infection. EVs released by bacterial pathogens may deliver toxins to host cells, signalling molecules and new DNA to other bacteria, and act as decoys, protecting infecting bacteria from immune killing. In this review, we explore the role of EVs in infection from the perspective of both the pathogen and host, and highlight their importance in the host/pathogen relationship. We highlight proposed strategies for EVs in therapeutics, and call attention to areas where existing knowledge and evidence is lacking. |
|
dc.format.medium |
Print |
|
dc.language |
eng |
|
dc.publisher |
Portland Press Ltd. |
|
dc.relation.ispartofseries |
Biochemical Society transactions |
|
dc.rights |
Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. |
|
dc.rights.uri |
https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm |
|
dc.rights.uri |
https://creativecommons.org/licenses/by-nc-nd/4.0/ |
|
dc.subject |
Animals |
|
dc.subject |
Humans |
|
dc.subject |
Bacteria |
|
dc.subject |
Bacterial Infections |
|
dc.subject |
Inflammation |
|
dc.subject |
Drug Resistance, Microbial |
|
dc.subject |
Virulence |
|
dc.subject |
Signal Transduction |
|
dc.subject |
Host-Pathogen Interactions |
|
dc.subject |
Extracellular Vesicles |
|
dc.subject |
immune response |
|
dc.subject |
infection |
|
dc.subject |
pathogen |
|
dc.subject |
Infectious Diseases |
|
dc.subject |
Vaccine Related |
|
dc.subject |
Prevention |
|
dc.subject |
Genetics |
|
dc.subject |
2.2 Factors relating to the physical environment |
|
dc.subject |
2.1 Biological and endogenous factors |
|
dc.subject |
Infection |
|
dc.subject |
Science & Technology |
|
dc.subject |
Life Sciences & Biomedicine |
|
dc.subject |
Biochemistry & Molecular Biology |
|
dc.subject |
OUTER-MEMBRANE VESICLES |
|
dc.subject |
CYTOLETHAL DISTENDING TOXIN |
|
dc.subject |
HELICOBACTER-PYLORI |
|
dc.subject |
STAPHYLOCOCCUS-AUREUS |
|
dc.subject |
IMMUNE CELLS |
|
dc.subject |
IN-VITRO |
|
dc.subject |
EXOSOMES |
|
dc.subject |
RELEASE |
|
dc.subject |
SECRETION |
|
dc.subject |
0601 Biochemistry and Cell Biology |
|
dc.subject |
1101 Medical Biochemistry and Metabolomics |
|
dc.title |
The complex, bidirectional role of extracellular vesicles in infection. |
|
dc.type |
Journal Article |
|
dc.identifier.doi |
10.1042/bst20200788 |
|
pubs.issue |
2 |
|
pubs.begin-page |
881 |
|
pubs.volume |
49 |
|
dc.date.updated |
2022-05-23T02:52:57Z |
|
dc.rights.holder |
Copyright: The author |
en |
dc.identifier.pmid |
33860784 (pubmed) |
|
pubs.author-url |
https://www.ncbi.nlm.nih.gov/pubmed/33860784 |
|
pubs.end-page |
891 |
|
pubs.publication-status |
Published |
|
dc.rights.accessrights |
http://purl.org/eprint/accessRights/OpenAccess |
en |
pubs.subtype |
Research Support, Non-U.S. Gov't |
|
pubs.subtype |
review-article |
|
pubs.subtype |
Review |
|
pubs.subtype |
Journal Article |
|
pubs.elements-id |
848044 |
|
pubs.org-id |
Medical and Health Sciences |
|
pubs.org-id |
Science |
|
pubs.org-id |
Physics |
|
pubs.org-id |
Biological Sciences |
|
pubs.org-id |
Science Research |
|
pubs.org-id |
Medical Sciences |
|
pubs.org-id |
Molecular Medicine |
|
pubs.org-id |
School of Medicine |
|
pubs.org-id |
Obstetrics and Gynaecology |
|
pubs.org-id |
Surgery Department |
|
pubs.org-id |
Maurice Wilkins Centre (2010-2014) |
|
dc.identifier.eissn |
1470-8752 |
|
dc.identifier.pii |
228376 |
|
pubs.record-created-at-source-date |
2022-05-23 |
|
pubs.online-publication-date |
2021-04-16 |
|