dc.contributor.author |
Handsfield, Geoffrey G |
|
dc.contributor.author |
Williams, Sîan |
|
dc.contributor.author |
Khuu, Stephanie |
|
dc.contributor.author |
Lichtwark, Glen |
|
dc.contributor.author |
Stott, N Susan |
|
dc.coverage.spatial |
England |
|
dc.date.accessioned |
2022-06-20T22:00:42Z |
|
dc.date.available |
2022-06-20T22:00:42Z |
|
dc.date.issued |
2022-03-10 |
|
dc.identifier.citation |
(2022). BMC Musculoskeletal Disorders, 23(1), 233-. |
|
dc.identifier.issn |
1471-2474 |
|
dc.identifier.uri |
https://hdl.handle.net/2292/60022 |
|
dc.description.abstract |
Cerebral palsy (CP) is caused by a static lesion to the brain occurring in utero or up to the first 2 years of life; it often manifests as musculoskeletal impairments and movement disorders including spasticity and contractures. Variable manifestation of the pathology across individuals, coupled with differing mechanics and treatments, leads to a heterogeneous collection of clinical phenotypes that affect muscles and individuals differently. Growth of muscles in CP deviates from typical development, evident as early as 15 months of age. Muscles in CP may be reduced in volume by as much as 40%, may be shorter in length, present longer tendons, and may have fewer sarcomeres in series that are overstretched compared to typical. Macroscale and functional deficits are likely mediated by dysfunction at the cellular level, which manifests as impaired growth. Within muscle fibres, satellite cells are decreased by as much as 40-70% and the regenerative capacity of remaining satellite cells appears compromised. Impaired muscle regeneration in CP is coupled with extracellular matrix expansion and increased pro-inflammatory gene expression; resultant muscles are smaller, stiffer, and weaker than typical muscle. These differences may contribute to individuals with CP participating in less physical activity, thus decreasing opportunities for mechanical loading, commencing a vicious cycle of muscle disuse and secondary sarcopenia. This narrative review describes the effects of CP on skeletal muscles encompassing substantive changes from whole muscle function to cell-level effects and the effects of common treatments. We discuss growth and mechanics of skeletal muscles in CP and propose areas where future work is needed to understand these interactions, particularly the link between neural insult and cell-level manifestation of CP. |
|
dc.format.medium |
Electronic |
|
dc.language |
eng |
|
dc.publisher |
Springer Science and Business Media LLC |
|
dc.relation.ispartofseries |
BMC musculoskeletal disorders |
|
dc.rights |
Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. |
|
dc.rights.uri |
https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm |
|
dc.rights.uri |
https://creativecommons.org/licenses/by/4.0/ |
|
dc.subject |
Muscle, Skeletal |
|
dc.subject |
Humans |
|
dc.subject |
Contracture |
|
dc.subject |
Muscle Spasticity |
|
dc.subject |
Cerebral Palsy |
|
dc.subject |
Muscle Fibers, Skeletal |
|
dc.subject |
Clinical Research |
|
dc.subject |
Brain Disorders |
|
dc.subject |
Pediatric |
|
dc.subject |
Intellectual and Developmental Disabilities (IDD) |
|
dc.subject |
Rehabilitation |
|
dc.subject |
Neurosciences |
|
dc.subject |
Regenerative Medicine |
|
dc.subject |
Stem Cell Research |
|
dc.subject |
Perinatal Period - Conditions Originating in Perinatal Period |
|
dc.subject |
2.1 Biological and endogenous factors |
|
dc.subject |
1.1 Normal biological development and functioning |
|
dc.subject |
Musculoskeletal |
|
dc.subject |
Neurological |
|
dc.subject |
Science & Technology |
|
dc.subject |
Life Sciences & Biomedicine |
|
dc.subject |
Orthopedics |
|
dc.subject |
Rheumatology |
|
dc.subject |
MEDIAL GASTROCNEMIUS-MUSCLE |
|
dc.subject |
SELECTIVE DORSAL RHIZOTOMY |
|
dc.subject |
GROSS MOTOR FUNCTION |
|
dc.subject |
TOXIN TYPE-A |
|
dc.subject |
BOTULINUM TOXIN |
|
dc.subject |
PHYSICAL-ACTIVITY |
|
dc.subject |
ACHILLES-TENDON |
|
dc.subject |
YOUNG-ADULTS |
|
dc.subject |
ELECTRICAL-STIMULATION |
|
dc.subject |
CLASSIFICATION-SYSTEM |
|
dc.subject |
1103 Clinical Sciences |
|
dc.title |
Muscle architecture, growth, and biological Remodelling in cerebral palsy: a narrative review. |
|
dc.type |
Journal Article |
|
dc.identifier.doi |
10.1186/s12891-022-05110-5 |
|
pubs.issue |
1 |
|
pubs.begin-page |
233 |
|
pubs.volume |
23 |
|
dc.date.updated |
2022-05-29T20:48:01Z |
|
dc.rights.holder |
Copyright: The author |
en |
dc.identifier.pmid |
35272643 (pubmed) |
|
pubs.author-url |
https://www.ncbi.nlm.nih.gov/pubmed/35272643 |
|
pubs.publication-status |
Published |
|
dc.rights.accessrights |
http://purl.org/eprint/accessRights/OpenAccess |
en |
pubs.subtype |
review-article |
|
pubs.subtype |
Review |
|
pubs.subtype |
Journal Article |
|
pubs.elements-id |
888728 |
|
pubs.org-id |
Bioengineering Institute |
|
pubs.org-id |
Liggins Institute |
|
pubs.org-id |
Medical and Health Sciences |
|
pubs.org-id |
School of Medicine |
|
pubs.org-id |
Surgery Department |
|
dc.identifier.eissn |
1471-2474 |
|
dc.identifier.pii |
10.1186/s12891-022-05110-5 |
|
pubs.number |
233 |
|
pubs.record-created-at-source-date |
2022-05-30 |
|
pubs.online-publication-date |
2022-03-10 |
|