Evidence that alpha calcitonin gene-related peptide is a neurohormone that regulates systemic lipid availability and utilization

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dc.contributor.author Watson, RN
dc.contributor.author Loomes, KM
dc.contributor.author Leonard, BL
dc.contributor.author Whiting, L
dc.contributor.author Hay, DL
dc.contributor.author Xu, LY
dc.contributor.author Kraegen, EW
dc.contributor.author Phillips, ARJ
dc.contributor.author Cooper, GJS
dc.coverage.spatial United States
dc.date.accessioned 2022-06-21T23:38:09Z
dc.date.available 2022-06-21T23:38:09Z
dc.date.issued 2008
dc.identifier.citation (2008). Endocrinology, 149(1), 154-160.
dc.identifier.issn 0013-7227
dc.identifier.uri https://hdl.handle.net/2292/60061
dc.description.abstract Alpha-calcitonin gene-related peptide (alphaCGRP) is released mainly from sensory and motor nerves in response to physiological stimuli. Despite well-documented pharmacological effects, its primary physiological role has thus far remained obscure. Increased lipid content, particularly in skeletal muscle and liver, is strongly implicated in the pathogenesis of insulin resistance, but the physiological regulation of organ lipid is imperfectly understood. Here we report our systematic investigations of the effects of alphaCGRP on in vitro and in vivo indices of lipid metabolism. In rodents, levels of alphaCGRP similar to those in the blood markedly stimulated fatty acid beta-oxidation and evoked concomitant mobilization of muscle lipid via receptor-mediated activation of muscle lipolysis. alphaCGRP exerted potent in vivo effects on lipid metabolism in muscle, liver, and the blood via receptor-mediated pathways. Studies with receptor antagonists were consistent with tonic regulation of lipid metabolism by an endogenous CGRP agonist. These data reveal that alphaCGRP is a newly recognized regulator of lipid availability and utilization in key tissues and that it may elevate the availability of intramyocellular free fatty acids to meet muscle energy requirements generated by contraction by evoking their release from endogenous triglyceride.
dc.format.medium Print-Electronic
dc.language eng
dc.publisher The Endocrine Society
dc.relation.ispartofseries Endocrinology
dc.rights Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher.
dc.rights.uri https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm
dc.subject Muscle, Skeletal
dc.subject Animals
dc.subject Rats
dc.subject Rats, Wistar
dc.subject Multienzyme Complexes
dc.subject Fatty Acids
dc.subject Calcitonin Gene-Related Peptide
dc.subject Receptors, Calcitonin Gene-Related Peptide
dc.subject Cyclic AMP
dc.subject Neurotransmitter Agents
dc.subject Oxidation-Reduction
dc.subject Lipolysis
dc.subject Phosphorylation
dc.subject Male
dc.subject Lipid Metabolism
dc.subject AMP-Activated Protein Kinases
dc.subject Protein Serine-Threonine Kinases
dc.subject Nutrition
dc.subject Liver Disease
dc.subject Digestive Diseases
dc.subject 2.1 Biological and endogenous factors
dc.subject Metabolic and endocrine
dc.subject Science & Technology
dc.subject Life Sciences & Biomedicine
dc.subject Endocrinology & Metabolism
dc.subject AMYLIN
dc.subject CGRP
dc.subject RAT
dc.subject METABOLISM
dc.subject RECEPTOR
dc.subject Protein-Serine-Threonine Kinases
dc.subject 1116 Medical Physiology
dc.subject 1103 Clinical Sciences
dc.subject Biomedical
dc.subject Basic Science
dc.subject 06 Biological Sciences
dc.subject 07 Agricultural and Veterinary Sciences
dc.subject 11 Medical and Health Sciences
dc.title Evidence that alpha calcitonin gene-related peptide is a neurohormone that regulates systemic lipid availability and utilization
dc.type Journal Article
dc.identifier.doi 10.1210/en.2007-0583
pubs.issue 1
pubs.begin-page 154
pubs.volume 149
dc.date.updated 2022-05-03T04:50:33Z
dc.rights.holder Copyright: The author en
dc.identifier.pmid 17932220 (pubmed)
pubs.author-url https://www.ncbi.nlm.nih.gov/pubmed/17932220
pubs.end-page 160
pubs.publication-status Published
dc.rights.accessrights http://purl.org/eprint/accessRights/RestrictedAccess en
pubs.subtype Article
pubs.elements-id 73605
pubs.org-id Science
pubs.org-id Biological Sciences
pubs.org-id Science Research
pubs.org-id Maurice Wilkins Centre (2010-2014)
dc.identifier.eissn 1945-7170
dc.identifier.pii en.2007-0583
pubs.record-created-at-source-date 2022-05-03
pubs.online-publication-date 2007-10-11

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