dc.contributor.author |
Dabbour, Abdel-Hameed |
|
dc.contributor.author |
Tan, Sheryl |
|
dc.contributor.author |
Kim, Sang Ho |
|
dc.contributor.author |
Guild, Sarah-Jane |
|
dc.contributor.author |
Heppner, Peter |
|
dc.contributor.author |
McCormick, Daniel |
|
dc.contributor.author |
Wright, Bryon E |
|
dc.contributor.author |
Leung, Dixon |
|
dc.contributor.author |
Gallichan, Robert |
|
dc.contributor.author |
Budgett, David |
|
dc.contributor.author |
Malpas, Simon C |
|
dc.coverage.spatial |
Switzerland |
|
dc.date.accessioned |
2022-06-29T23:44:18Z |
|
dc.date.available |
2022-06-29T23:44:18Z |
|
dc.date.issued |
2021-01 |
|
dc.identifier.citation |
(2021). Frontiers in Neuroscience, 15, 796203-. |
|
dc.identifier.issn |
1662-4548 |
|
dc.identifier.uri |
https://hdl.handle.net/2292/60237 |
|
dc.description.abstract |
Technological advancements in electronics and micromachining now allow the development of discrete wireless brain implantable micro-devices. Applications of such devices include stimulation or sensing and could enable direct placement near regions of interest within the brain without the need for electrode leads or separate battery compartments that are at increased risk of breakage and infection. Clinical use of leadless brain implants is accompanied by novel risks, such as migration of the implant. Additionally, the encapsulation material of the implants plays an important role in mitigating unwanted tissue reactions. These risks have the potential to cause harm or reduce the service of life of the implant. In the present study, we have assessed post-implantation tissue reaction and migration of borosilicate glass-encapsulated micro-implants within the cortex of the brain. Twenty borosilicate glass-encapsulated devices (2 × 3.5 × 20 mm) were implanted into the parenchyma of 10 sheep for 6 months. Radiographs were taken directly post-surgery and at 3 and 6 months. Subsequently, sheep were euthanized, and GFAP and IBA-1 histological analysis was performed. The migration of the implants was tracked by reference to two stainless steel screws placed in the skull. We found no significant difference in fluoroscopy intensity of GFAP and a small difference in IBA-1 between implanted tissue and control. There was no glial scar formation found at the site of the implant's track wall. Furthermore, we observed movement of up to 4.6 mm in a subset of implants in the first 3 months of implantation and no movement in any implant during the 3-6-month period of implantation. Subsequent histological analysis revealed no evidence of a migration track or tissue damage. We conclude that the implantation of this discrete micro-implant within the brain does not present additional risk due to migration. |
|
dc.format.medium |
Electronic-eCollection |
|
dc.language |
eng |
|
dc.publisher |
Frontiers Media SA |
|
dc.relation.ispartofseries |
Frontiers in neuroscience |
|
dc.rights |
Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. |
|
dc.rights.uri |
https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm |
|
dc.rights.uri |
https://creativecommons.org/licenses/by/4.0/ |
|
dc.subject |
brain implant |
|
dc.subject |
implant migration |
|
dc.subject |
micro-implant |
|
dc.subject |
micro-implant GFAP |
|
dc.subject |
micro-implant IBA-1 |
|
dc.subject |
micro-implant safety |
|
dc.subject |
microdevice |
|
dc.subject |
Assistive Technology |
|
dc.subject |
Neurosciences |
|
dc.subject |
Patient Safety |
|
dc.subject |
Bioengineering |
|
dc.subject |
5.3 Medical devices |
|
dc.subject |
Science & Technology |
|
dc.subject |
Life Sciences & Biomedicine |
|
dc.subject |
Neurosciences & Neurology |
|
dc.subject |
HARDWARE-RELATED COMPLICATIONS |
|
dc.subject |
VAGUS-NERVE-STIMULATION |
|
dc.subject |
BOROSILICATE GLASS |
|
dc.subject |
LONG-TERM |
|
dc.subject |
TISSUE |
|
dc.subject |
SILICON |
|
dc.subject |
INFECTIONS |
|
dc.subject |
RESPONSES |
|
dc.subject |
1109 Neurosciences |
|
dc.subject |
1701 Psychology |
|
dc.subject |
1702 Cognitive Sciences |
|
dc.title |
The Safety of Micro-Implants for the Brain. |
|
dc.type |
Journal Article |
|
dc.identifier.doi |
10.3389/fnins.2021.796203 |
|
pubs.begin-page |
796203 |
|
pubs.volume |
15 |
|
dc.date.updated |
2022-05-02T22:25:12Z |
|
dc.rights.holder |
Copyright: The author |
en |
dc.identifier.pmid |
34955740 (pubmed) |
|
pubs.author-url |
https://www.ncbi.nlm.nih.gov/pubmed/34955740 |
|
pubs.publication-status |
Published |
|
dc.rights.accessrights |
http://purl.org/eprint/accessRights/OpenAccess |
en |
pubs.subtype |
research-article |
|
pubs.subtype |
Journal Article |
|
pubs.elements-id |
878783 |
|
pubs.org-id |
Bioengineering Institute |
|
pubs.org-id |
Medical and Health Sciences |
|
pubs.org-id |
Medical Sciences |
|
pubs.org-id |
Anatomy and Medical Imaging |
|
pubs.org-id |
Physiology Division |
|
pubs.org-id |
ABI Associates |
|
dc.identifier.eissn |
1662-453X |
|
pubs.number |
ARTN 796203 |
|
pubs.record-created-at-source-date |
2022-05-03 |
|
pubs.online-publication-date |
2021-12-09 |
|