The Safety of Micro-Implants for the Brain.

Show simple item record Dabbour, Abdel-Hameed Tan, Sheryl Kim, Sang Ho Guild, Sarah-Jane Heppner, Peter McCormick, Daniel Wright, Bryon E Leung, Dixon Gallichan, Robert Budgett, David Malpas, Simon C
dc.coverage.spatial Switzerland 2022-06-29T23:44:18Z 2022-06-29T23:44:18Z 2021-01
dc.identifier.citation (2021). Frontiers in Neuroscience, 15, 796203-.
dc.identifier.issn 1662-4548
dc.description.abstract Technological advancements in electronics and micromachining now allow the development of discrete wireless brain implantable micro-devices. Applications of such devices include stimulation or sensing and could enable direct placement near regions of interest within the brain without the need for electrode leads or separate battery compartments that are at increased risk of breakage and infection. Clinical use of leadless brain implants is accompanied by novel risks, such as migration of the implant. Additionally, the encapsulation material of the implants plays an important role in mitigating unwanted tissue reactions. These risks have the potential to cause harm or reduce the service of life of the implant. In the present study, we have assessed post-implantation tissue reaction and migration of borosilicate glass-encapsulated micro-implants within the cortex of the brain. Twenty borosilicate glass-encapsulated devices (2 × 3.5 × 20 mm) were implanted into the parenchyma of 10 sheep for 6 months. Radiographs were taken directly post-surgery and at 3 and 6 months. Subsequently, sheep were euthanized, and GFAP and IBA-1 histological analysis was performed. The migration of the implants was tracked by reference to two stainless steel screws placed in the skull. We found no significant difference in fluoroscopy intensity of GFAP and a small difference in IBA-1 between implanted tissue and control. There was no glial scar formation found at the site of the implant's track wall. Furthermore, we observed movement of up to 4.6 mm in a subset of implants in the first 3 months of implantation and no movement in any implant during the 3-6-month period of implantation. Subsequent histological analysis revealed no evidence of a migration track or tissue damage. We conclude that the implantation of this discrete micro-implant within the brain does not present additional risk due to migration.
dc.format.medium Electronic-eCollection
dc.language eng
dc.publisher Frontiers Media SA
dc.relation.ispartofseries Frontiers in neuroscience
dc.rights Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher.
dc.subject brain implant
dc.subject implant migration
dc.subject micro-implant
dc.subject micro-implant GFAP
dc.subject micro-implant IBA-1
dc.subject micro-implant safety
dc.subject microdevice
dc.subject Assistive Technology
dc.subject Neurosciences
dc.subject Patient Safety
dc.subject Bioengineering
dc.subject 5.3 Medical devices
dc.subject Science & Technology
dc.subject Life Sciences & Biomedicine
dc.subject Neurosciences & Neurology
dc.subject LONG-TERM
dc.subject TISSUE
dc.subject SILICON
dc.subject INFECTIONS
dc.subject RESPONSES
dc.subject 1109 Neurosciences
dc.subject 1701 Psychology
dc.subject 1702 Cognitive Sciences
dc.title The Safety of Micro-Implants for the Brain.
dc.type Journal Article
dc.identifier.doi 10.3389/fnins.2021.796203
pubs.begin-page 796203
pubs.volume 15 2022-05-02T22:25:12Z
dc.rights.holder Copyright: The author en
dc.identifier.pmid 34955740 (pubmed)
pubs.publication-status Published
dc.rights.accessrights en
pubs.subtype research-article
pubs.subtype Journal Article
pubs.elements-id 878783 Bioengineering Institute Medical and Health Sciences Medical Sciences Anatomy and Medical Imaging Physiology Division ABI Associates
dc.identifier.eissn 1662-453X
pubs.number ARTN 796203
pubs.record-created-at-source-date 2022-05-03 2021-12-09

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