dc.contributor.author |
Broome, SC |
|
dc.contributor.author |
Pham, T |
|
dc.contributor.author |
Braakhuis, AJ |
|
dc.contributor.author |
Narang, R |
|
dc.contributor.author |
Wang, HW |
|
dc.contributor.author |
Hickey, AJR |
|
dc.contributor.author |
Mitchell, CJ |
|
dc.contributor.author |
Merry, TL |
|
dc.coverage.spatial |
Netherlands |
|
dc.date.accessioned |
2022-07-24T21:22:24Z |
|
dc.date.available |
2022-07-24T21:22:24Z |
|
dc.date.issued |
2022-07 |
|
dc.identifier.citation |
(2022). Redox Biology, 53, 102341-. |
|
dc.identifier.issn |
2213-2317 |
|
dc.identifier.uri |
https://hdl.handle.net/2292/60467 |
|
dc.description.abstract |
The role of mitochondrial ROS in signalling muscle adaptations to exercise training has not been explored in detail. We investigated the effect of supplementation with the mitochondria-targeted antioxidant MitoQ on a) the skeletal muscle mitochondrial and antioxidant gene transcriptional response to acute high-intensity exercise and b) skeletal muscle mitochondrial content and function following exercise training. In a randomised, double-blind, placebo-controlled, parallel design study, 23 untrained men (age: 44 ± 7 years, VO<sub>2peak</sub>: 39.6 ± 7.9 ml/kg/min) were randomised to receive either MitoQ (20 mg/d) or a placebo for 10 days before completing a bout of high-intensity interval exercise (cycle ergometer, 10 × 60 s at VO<sub>2peak</sub> workload with 75 s rest). Blood samples and vastus lateralis muscle biopsies were collected before exercise and immediately and 3 h after exercise. Participants then completed high-intensity interval training (HIIT; 3 sessions per week for 3 weeks) and another blood sample and muscle biopsy were collected. There was no effect of acute exercise or MitoQ on systemic (plasma protein carbonyls and reduced glutathione) or skeletal muscle (mtDNA damage and 4-HNE) oxidative stress biomarkers. Acute exercise-induced increases in skeletal muscle peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC1-α) mRNA expression were augmented in the MitoQ group. Despite this, training-induced increases in skeletal muscle mitochondrial content were similar between groups. HIIT-induced increases in VO<sub>2peak</sub> and 20 km time trial performance were also similar between groups while training-induced increases in peak power achieved during the VO<sub>2peak</sub> test were augmented in the MitoQ group. These data suggest that training-induced increases in peak power are enhanced following MitoQ supplementation, which may be related to the augmentation of skeletal muscle PGC1α expression following acute exercise. However, these effects do not appear to be related to an effect of MitoQ supplementation on exercise-induced oxidative stress or training-induced mitochondrial biogenesis in skeletal muscle. |
|
dc.format.medium |
Print-Electronic |
|
dc.language |
eng |
|
dc.publisher |
Elsevier |
|
dc.relation.ispartofseries |
Redox biology |
|
dc.rights |
Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. |
|
dc.rights.uri |
https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm |
|
dc.rights.uri |
https://creativecommons.org/licenses/by-nc-nd/4.0/ |
|
dc.subject |
Adaptation |
|
dc.subject |
Antioxidant |
|
dc.subject |
Exercise |
|
dc.subject |
Mitochondria |
|
dc.subject |
Performance |
|
dc.subject |
ROS |
|
dc.subject |
Adult |
|
dc.subject |
Antioxidants |
|
dc.subject |
Dietary Supplements |
|
dc.subject |
Humans |
|
dc.subject |
Male |
|
dc.subject |
Middle Aged |
|
dc.subject |
Muscle, Skeletal |
|
dc.subject |
Organophosphorus Compounds |
|
dc.subject |
Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha |
|
dc.subject |
RNA, Messenger |
|
dc.subject |
Ubiquinone |
|
dc.subject |
Complementary and Integrative Health |
|
dc.subject |
Nutrition |
|
dc.subject |
Clinical Trials and Supportive Activities |
|
dc.subject |
Genetics |
|
dc.subject |
Clinical Research |
|
dc.subject |
6.7 Physical |
|
dc.subject |
6 Evaluation of treatments and therapeutic interventions |
|
dc.subject |
6.1 Pharmaceuticals |
|
dc.subject |
Musculoskeletal |
|
dc.subject |
0601 Biochemistry and Cell Biology |
|
dc.subject |
1101 Medical Biochemistry and Metabolomics |
|
dc.subject |
1115 Pharmacology and Pharmaceutical Sciences |
|
dc.title |
MitoQ supplementation augments acute exercise-induced increases in muscle PGC1α mRNA and improves training-induced increases in peak power independent of mitochondrial content and function in untrained middle-aged men. |
|
dc.type |
Journal Article |
|
dc.identifier.doi |
10.1016/j.redox.2022.102341 |
|
pubs.begin-page |
102341 |
|
pubs.volume |
53 |
|
dc.date.updated |
2022-06-19T21:28:02Z |
|
dc.rights.holder |
Copyright: The author |
en |
dc.identifier.pmid |
35623315 (pubmed) |
|
pubs.author-url |
https://www.ncbi.nlm.nih.gov/pubmed/35623315 |
|
pubs.publication-status |
Accepted |
|
dc.rights.accessrights |
http://purl.org/eprint/accessRights/OpenAccess |
en |
pubs.subtype |
research-article |
|
pubs.subtype |
Journal Article |
|
pubs.elements-id |
906362 |
|
pubs.org-id |
Bioengineering Institute |
|
pubs.org-id |
Medical and Health Sciences |
|
pubs.org-id |
Medical Sciences |
|
pubs.org-id |
Nutrition |
|
dc.identifier.eissn |
2213-2317 |
|
dc.identifier.pii |
S2213-2317(22)00113-6 |
|
pubs.number |
102341 |
|
pubs.record-created-at-source-date |
2022-06-20 |
|
pubs.online-publication-date |
2022-07 |
|