dc.contributor.author |
Morse, James D |
|
dc.contributor.author |
Cortinez, Luis Ignacio |
|
dc.contributor.author |
Anderson, Brian J |
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dc.date.accessioned |
2022-07-25T03:47:18Z |
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dc.date.available |
2022-07-25T03:47:18Z |
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dc.date.issued |
2022-05-26 |
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dc.identifier.citation |
(2022). Journal of Clinical Medicine, 11(11), 3009-. |
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dc.identifier.issn |
2077-0383 |
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dc.identifier.uri |
https://hdl.handle.net/2292/60499 |
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dc.description.abstract |
<jats:p>The use of pharmacokinetic-pharmacodynamic models has improved anaesthesia practice in children through a better understanding of dose-concentration-response relationships, developmental pharmacokinetic changes, quantification of drug interactions and insights into how covariates (e.g., age, size, organ dysfunction, pharmacogenomics) impact drug prescription. Simulation using information from these models has enabled the prediction and learning of beneficial and adverse effects and decision-making around clinical scenarios. Covariate information, including the use of allometric size scaling, age and consideration of fat mass, has reduced population parameter variability. The target concentration approach has rationalised dose calculation. Paediatric pharmacokinetic-pharmacodynamic insights have led to better drug delivery systems for total intravenous anaesthesia and an expectation about drug offset when delivery is stopped. Understanding concentration-dependent adverse effects have tempered dose regimens. Quantification of drug interactions has improved the understanding of the effects of drug combinations. Repurposed drugs (e.g., antiviral drugs used for COVID-19) within the community can have important effects on drugs used in paediatric anaesthesia, and the use of simulation educates about these drug vagaries.</jats:p> |
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dc.language |
en |
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dc.publisher |
MDPI |
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dc.relation.ispartofseries |
Journal of Clinical Medicine |
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dc.rights |
Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. |
|
dc.rights.uri |
https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm |
|
dc.rights.uri |
https://creativecommons.org/licenses/by/4.0/ |
|
dc.subject |
Orphan Drug |
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dc.subject |
Patient Safety |
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dc.subject |
Rare Diseases |
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dc.subject |
6 Evaluation of treatments and therapeutic interventions |
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dc.subject |
6.1 Pharmaceuticals |
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dc.subject |
5 Development of treatments and therapeutic interventions |
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dc.subject |
5.1 Pharmaceuticals |
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dc.subject |
Generic health relevance |
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dc.subject |
1103 Clinical Sciences |
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dc.title |
Pharmacokinetic Pharmacodynamic Modelling Contributions to Improve Paediatric Anaesthesia Practice |
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dc.type |
Journal Article |
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dc.identifier.doi |
10.3390/jcm11113009 |
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pubs.issue |
11 |
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pubs.begin-page |
3009 |
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pubs.volume |
11 |
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dc.date.updated |
2022-06-15T03:39:20Z |
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dc.rights.holder |
Copyright: The author |
en |
pubs.publication-status |
Published online |
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dc.rights.accessrights |
http://purl.org/eprint/accessRights/OpenAccess |
en |
pubs.elements-id |
905741 |
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pubs.org-id |
Medical and Health Sciences |
|
pubs.org-id |
Medical Sciences |
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pubs.org-id |
School of Medicine |
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pubs.org-id |
Anaesthesiology |
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dc.identifier.eissn |
2077-0383 |
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pubs.record-created-at-source-date |
2022-06-15 |
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pubs.online-publication-date |
2022-05-26 |
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