Pharmacokinetic Pharmacodynamic Modelling Contributions to Improve Paediatric Anaesthesia Practice

Show simple item record Morse, James D Cortinez, Luis Ignacio Anderson, Brian J 2022-07-25T03:47:18Z 2022-07-25T03:47:18Z 2022-05-26
dc.identifier.citation (2022). Journal of Clinical Medicine, 11(11), 3009-.
dc.identifier.issn 2077-0383
dc.description.abstract <jats:p>The use of pharmacokinetic-pharmacodynamic models has improved anaesthesia practice in children through a better understanding of dose-concentration-response relationships, developmental pharmacokinetic changes, quantification of drug interactions and insights into how covariates (e.g., age, size, organ dysfunction, pharmacogenomics) impact drug prescription. Simulation using information from these models has enabled the prediction and learning of beneficial and adverse effects and decision-making around clinical scenarios. Covariate information, including the use of allometric size scaling, age and consideration of fat mass, has reduced population parameter variability. The target concentration approach has rationalised dose calculation. Paediatric pharmacokinetic-pharmacodynamic insights have led to better drug delivery systems for total intravenous anaesthesia and an expectation about drug offset when delivery is stopped. Understanding concentration-dependent adverse effects have tempered dose regimens. Quantification of drug interactions has improved the understanding of the effects of drug combinations. Repurposed drugs (e.g., antiviral drugs used for COVID-19) within the community can have important effects on drugs used in paediatric anaesthesia, and the use of simulation educates about these drug vagaries.</jats:p>
dc.language en
dc.publisher MDPI
dc.relation.ispartofseries Journal of Clinical Medicine
dc.rights Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher.
dc.subject Orphan Drug
dc.subject Patient Safety
dc.subject Rare Diseases
dc.subject 6 Evaluation of treatments and therapeutic interventions
dc.subject 6.1 Pharmaceuticals
dc.subject 5 Development of treatments and therapeutic interventions
dc.subject 5.1 Pharmaceuticals
dc.subject Generic health relevance
dc.subject 1103 Clinical Sciences
dc.title Pharmacokinetic Pharmacodynamic Modelling Contributions to Improve Paediatric Anaesthesia Practice
dc.type Journal Article
dc.identifier.doi 10.3390/jcm11113009
pubs.issue 11
pubs.begin-page 3009
pubs.volume 11 2022-06-15T03:39:20Z
dc.rights.holder Copyright: The author en
pubs.publication-status Published online
dc.rights.accessrights en
pubs.elements-id 905741 Medical and Health Sciences Medical Sciences School of Medicine Anaesthesiology
dc.identifier.eissn 2077-0383
pubs.record-created-at-source-date 2022-06-15 2022-05-26

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