dc.contributor.author |
Sluyter, John D |
|
dc.contributor.author |
Camargo, Carlos A |
|
dc.contributor.author |
Waayer, Debbie |
|
dc.contributor.author |
Lawes, Carlene MM |
|
dc.contributor.author |
Toop, Les |
|
dc.contributor.author |
Khaw, Kay-Tee |
|
dc.contributor.author |
Scragg, Robert |
|
dc.coverage.spatial |
Switzerland |
|
dc.date.accessioned |
2022-07-25T03:54:54Z |
|
dc.date.available |
2022-07-25T03:54:54Z |
|
dc.date.issued |
2017-12-13 |
|
dc.identifier.citation |
(2017). Nutrients, 9(12), E1353-. |
|
dc.identifier.issn |
2072-6643 |
|
dc.identifier.uri |
https://hdl.handle.net/2292/60501 |
|
dc.description.abstract |
Although observational studies suggest positive vitamin D-lung function associations, randomized trials are inconsistent. We examined effects of vitamin D supplementation on lung function. We recruited 442 adults (50-84 years, 58% male) into a randomized, double-blinded, placebo-controlled trial. Participants received, for 1.1 years (median; range = 0.9-1.5 years), either (1) vitamin D₃ 200,000 IU, followed by monthly 100,000 IU doses (n = 226); or (2) placebo monthly (n = 216). At baseline and follow-up, spirometry yielded forced expiratory volume in 1 s (FEV1; primary outcome). Mean (standard deviation) 25-hydroxyvitamin D increased from 61 (24) nmol/L at baseline to 119 (45) nmol/L at follow-up in the vitamin D group, but was unchanged in the placebo group. There were no significant lung function improvements (vitamin D versus placebo) in the total sample, vitamin D-deficient participants or asthma/chronic obstructive pulmonary disease (COPD) participants. However, among ever-smokers (n = 217), the mean (95% confidence interval) FEV1 increase in the vitamin D versus placebo was 57 (4, 109) mL (p = 0.03). FEV1 increases were larger among vitamin D-deficient ever-smokers (n = 54): 122 (8, 236) mL (p = 0.04). FEV1 improvements were largest among ever-smokers with asthma/COPD (n = 60): 160 (53, 268) mL (p = 0.004). Thus, vitamin D supplementation did not improve lung function among everyone, but benefited ever-smokers, especially those with vitamin D deficiency or asthma/COPD. |
|
dc.format.medium |
Electronic |
|
dc.language |
eng |
|
dc.publisher |
MDPI |
|
dc.relation.ispartofseries |
Nutrients |
|
dc.rights |
Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. |
|
dc.rights.uri |
https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm |
|
dc.rights.uri |
https://creativecommons.org/licenses/by/4.0/ |
|
dc.subject |
Lung |
|
dc.subject |
Humans |
|
dc.subject |
Asthma |
|
dc.subject |
Pulmonary Disease, Chronic Obstructive |
|
dc.subject |
Vitamin D Deficiency |
|
dc.subject |
Vitamin D |
|
dc.subject |
Forced Expiratory Volume |
|
dc.subject |
Spirometry |
|
dc.subject |
Follow-Up Studies |
|
dc.subject |
Double-Blind Method |
|
dc.subject |
Dose-Response Relationship, Drug |
|
dc.subject |
Dietary Supplements |
|
dc.subject |
Aged |
|
dc.subject |
Aged, 80 and over |
|
dc.subject |
Middle Aged |
|
dc.subject |
Female |
|
dc.subject |
Male |
|
dc.subject |
forced expiratory volume in 1 s |
|
dc.subject |
lung function |
|
dc.subject |
randomized controlled trial |
|
dc.subject |
Clinical Trials and Supportive Activities |
|
dc.subject |
Nutrition |
|
dc.subject |
Chronic Obstructive Pulmonary Disease |
|
dc.subject |
Clinical Research |
|
dc.subject |
Complementary and Integrative Health |
|
dc.subject |
3 Prevention of disease and conditions, and promotion of well-being |
|
dc.subject |
6.1 Pharmaceuticals |
|
dc.subject |
3.3 Nutrition and chemoprevention |
|
dc.subject |
6 Evaluation of treatments and therapeutic interventions |
|
dc.subject |
Respiratory |
|
dc.subject |
Science & Technology |
|
dc.subject |
Life Sciences & Biomedicine |
|
dc.subject |
Nutrition & Dietetics |
|
dc.subject |
OBSTRUCTIVE PULMONARY-DISEASE |
|
dc.subject |
25-HYDROXYVITAMIN D |
|
dc.subject |
OXIDATIVE STRESS |
|
dc.subject |
ASTHMA CONTROL |
|
dc.subject |
SUPPLEMENTATION |
|
dc.subject |
ADULTS |
|
dc.subject |
SMOKING |
|
dc.subject |
HEALTH |
|
dc.subject |
RISK |
|
dc.subject |
1117 Public Health and Health Services |
|
dc.subject |
Clinical |
|
dc.subject |
Clinical Medicine and Science |
|
dc.subject |
Complementary and Alternative Medicine |
|
dc.subject |
Lung Cancer |
|
dc.subject |
Cancer |
|
dc.subject |
Prevention |
|
dc.subject |
0908 Food Sciences |
|
dc.subject |
1111 Nutrition and Dietetics |
|
dc.title |
Effect of Monthly, High-Dose, Long-Term Vitamin D on Lung Function: A Randomized Controlled Trial. |
|
dc.type |
Journal Article |
|
dc.identifier.doi |
10.3390/nu9121353 |
|
pubs.issue |
12 |
|
pubs.begin-page |
E1353 |
|
pubs.volume |
9 |
|
dc.date.updated |
2022-06-13T03:14:17Z |
|
dc.rights.holder |
Copyright: The author |
en |
dc.identifier.pmid |
29236049 (pubmed) |
|
pubs.author-url |
https://www.ncbi.nlm.nih.gov/pubmed/29236049 |
|
pubs.publication-status |
Published |
|
dc.rights.accessrights |
http://purl.org/eprint/accessRights/OpenAccess |
en |
pubs.subtype |
IM |
|
pubs.subtype |
research-article |
|
pubs.subtype |
Randomized Controlled Trial |
|
pubs.subtype |
Journal Article |
|
pubs.elements-id |
719693 |
|
pubs.org-id |
Medical and Health Sciences |
|
pubs.org-id |
Faculty Administration FMHS |
|
pubs.org-id |
Population Health |
|
pubs.org-id |
Epidemiology & Biostatistics |
|
pubs.org-id |
FMHS Research Support |
|
dc.identifier.eissn |
2072-6643 |
|
dc.identifier.pii |
nu9121353 |
|
pubs.number |
ARTN 1353 |
|
pubs.record-created-at-source-date |
2022-06-13 |
|
pubs.online-publication-date |
2017-12-13 |
|