dc.contributor.author |
Blanchette, P |
|
dc.contributor.author |
Gilchrist, CA |
|
dc.contributor.author |
Baker, RT |
|
dc.contributor.author |
Gray, DA |
|
dc.coverage.spatial |
England |
|
dc.date.accessioned |
2022-07-26T21:47:32Z |
|
dc.date.available |
2022-07-26T21:47:32Z |
|
dc.date.issued |
2001-09 |
|
dc.identifier.citation |
(2001). Oncogene, 20(39), 5533-5537. |
|
dc.identifier.issn |
0950-9232 |
|
dc.identifier.uri |
https://hdl.handle.net/2292/60559 |
|
dc.description.abstract |
The murine Unp gene encodes a widely expressed ubiquitin-specific protease. The predicted sequence of the UNP protein features motifs common to viral oncoproteins through which these proteins interact with the retinoblastoma gene product pRb, as well as the related 'pocket proteins' p107 and p130. We have explored the possibility that UNP interacts with pocket proteins, and report here that such associations can be detected in vitro and in cells. Associations of UNP and pocket proteins are sensitive to site-directed mutations in a manner directly analogous to those documented in viral oncoproteins. We conclude that within cells UNP does physically associate with pRb, and can also associate with p107 and p130. |
|
dc.format.medium |
Print |
|
dc.language |
eng |
|
dc.publisher |
Springer Nature |
|
dc.relation.ispartofseries |
Oncogene |
|
dc.rights |
Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. |
|
dc.rights.uri |
https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm |
|
dc.subject |
3T3 Cells |
|
dc.subject |
Tumor Cells, Cultured |
|
dc.subject |
Animals |
|
dc.subject |
Humans |
|
dc.subject |
Mice |
|
dc.subject |
Ubiquitin Thiolesterase |
|
dc.subject |
Endopeptidases |
|
dc.subject |
Proteins |
|
dc.subject |
Retinoblastoma Protein |
|
dc.subject |
Oncogene Proteins |
|
dc.subject |
Proto-Oncogene Proteins |
|
dc.subject |
Nuclear Proteins |
|
dc.subject |
Phosphoproteins |
|
dc.subject |
Mutagenesis, Site-Directed |
|
dc.subject |
Amino Acid Motifs |
|
dc.subject |
Retinoblastoma-Like Protein p130 |
|
dc.subject |
Retinoblastoma-Like Protein p107 |
|
dc.subject |
Ubiquitin-Specific Proteases |
|
dc.subject |
Rare Diseases |
|
dc.subject |
Science & Technology |
|
dc.subject |
Life Sciences & Biomedicine |
|
dc.subject |
Biochemistry & Molecular Biology |
|
dc.subject |
Oncology |
|
dc.subject |
Cell Biology |
|
dc.subject |
Genetics & Heredity |
|
dc.subject |
ubiquitin |
|
dc.subject |
Ubp |
|
dc.subject |
deubiquitinating enzyme |
|
dc.subject |
retinoblastoma |
|
dc.subject |
pocket protein |
|
dc.subject |
RETINOBLASTOMA GENE-PRODUCT |
|
dc.subject |
RB-RELATED P107 |
|
dc.subject |
CELL-CYCLE |
|
dc.subject |
REGULATED PROTEOLYSIS |
|
dc.subject |
MICE LACKING |
|
dc.subject |
C-MYC |
|
dc.subject |
PATHWAY |
|
dc.subject |
DEGRADATION |
|
dc.subject |
FAMILY |
|
dc.subject |
E2F |
|
dc.subject |
0601 Biochemistry and Cell Biology |
|
dc.subject |
Biomedical |
|
dc.subject |
Basic Science |
|
dc.subject |
1103 Clinical Sciences |
|
dc.subject |
1112 Oncology and Carcinogenesis |
|
dc.title |
Association of UNP, a ubiquitin-specific protease, with the pocket proteins pRb, p107 and p130. |
|
dc.type |
Journal Article |
|
dc.identifier.doi |
10.1038/sj.onc.1204823 |
|
pubs.issue |
39 |
|
pubs.begin-page |
5533 |
|
pubs.volume |
20 |
|
dc.date.updated |
2022-06-16T04:29:53Z |
|
dc.rights.holder |
Copyright: The author |
en |
dc.identifier.pmid |
11571651 (pubmed) |
|
pubs.author-url |
https://www.ncbi.nlm.nih.gov/pubmed/11571651 |
|
pubs.end-page |
5537 |
|
pubs.publication-status |
Published |
|
dc.rights.accessrights |
http://purl.org/eprint/accessRights/RestrictedAccess |
en |
pubs.subtype |
Research Support, Non-U.S. Gov't |
|
pubs.subtype |
Journal Article |
|
pubs.elements-id |
57395 |
|
pubs.org-id |
Medical and Health Sciences |
|
pubs.org-id |
School of Medicine |
|
pubs.org-id |
Paediatrics Child & Youth Hlth |
|
dc.identifier.eissn |
1476-5594 |
|
pubs.record-created-at-source-date |
2022-06-16 |
|
pubs.online-publication-date |
2001-09-06 |
|