Diagnosis of colour vision deficits using eye movements.

Show simple item record

dc.contributor.author Taore, Aryaman
dc.contributor.author Lobo, Gabriel
dc.contributor.author Turnbull, Philip R
dc.contributor.author Dakin, Steven C
dc.coverage.spatial England
dc.date.accessioned 2022-07-26T22:09:41Z
dc.date.available 2022-07-26T22:09:41Z
dc.date.issued 2022-05-11
dc.identifier.citation (2022). Scientific Reports, 12(1), 7734-.
dc.identifier.issn 2045-2322
dc.identifier.uri https://hdl.handle.net/2292/60561
dc.description.abstract We set out to develop a simple objective test of functional colour vision based on eye movements made in response to moving patterns. We exploit the finding that while the motion of a colour-defined stimulus can be cancelled by adding a low-contrast luminance-defined stimulus moving in the opposite direction, the "equivalent luminance contrast" required for such cancellation is reduced when colour vision is abnormal. We used a consumer-grade infrared eye-tracker to measure eye movements made in response to coloured patterns drifting at different speeds. An automated analysis of these movements estimated individuals' red-green equiluminant point and their equivalent luminance contrast. We tested 34 participants: 23 colour vision normal controls, 9 deuteranomalous and 2 protanomalous individuals. We obtained reliable estimates of strength of directed eye movements (i.e. combined optokinetic and voluntary tracking) for stimuli moving at 16 deg/s and could use these data to classify participants' colour vision status with a sensitivity rate of 90.9% and a specificity rate of 91.3%. We conclude that an objective test of functional colour vision combining a motion-nulling technique with an automated analysis of eye movements can diagnose and assess the severity of protanopia and deuteranopia. The test places minimal demands on patients (who simply view a series of moving patterns for less than 90 s), requires modest operator expertise, and can be run on affordable hardware.
dc.format.medium Electronic
dc.language eng
dc.publisher Springer Nature
dc.relation.ispartofseries Scientific reports
dc.rights Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher.
dc.rights.uri https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm
dc.rights.uri https://creativecommons.org/licenses/by/4.0/
dc.subject Humans
dc.subject Color Vision Defects
dc.subject Eye Movements
dc.subject Color Perception
dc.subject Motion Perception
dc.subject Contrast Sensitivity
dc.subject Color Vision
dc.subject Clinical Research
dc.subject 4.1 Discovery and preclinical testing of markers and technologies
dc.subject 4 Detection, screening and diagnosis
dc.subject Eye
dc.subject Science & Technology
dc.subject Multidisciplinary Sciences
dc.subject Science & Technology - Other Topics
dc.subject RED-GREEN
dc.subject GENE-THERAPY
dc.subject MOTION
dc.subject LUMINANCE
dc.subject DOMINANCE
dc.subject DIRECTION
dc.subject CONTRAST
dc.title Diagnosis of colour vision deficits using eye movements.
dc.type Journal Article
dc.identifier.doi 10.1038/s41598-022-11152-5
pubs.issue 1
pubs.begin-page 7734
pubs.volume 12
dc.date.updated 2022-06-14T00:12:19Z
dc.rights.holder Copyright: The author en
dc.identifier.pmid 35562176 (pubmed)
pubs.author-url https://www.ncbi.nlm.nih.gov/pubmed/35562176
pubs.publication-status Published
dc.rights.accessrights http://purl.org/eprint/accessRights/OpenAccess en
pubs.subtype research-article
pubs.subtype Journal Article
pubs.elements-id 902802
pubs.org-id Medical and Health Sciences
pubs.org-id Optometry and Vision Science
dc.identifier.eissn 2045-2322
dc.identifier.pii 10.1038/s41598-022-11152-5
pubs.number 7734
pubs.record-created-at-source-date 2022-06-14
pubs.online-publication-date 2022-12

Files in this item

Find Full text

This item appears in the following Collection(s)

Show simple item record


Search ResearchSpace