Assessing the Impact of E-cigarette Particle Size on Aerosol Transport and Deposition in the Lung

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dc.contributor.advisor Burrowes, Kelly
dc.contributor.advisor Suresh, Vinod Lal, Swashna 2022-08-02T02:11:06Z 2022-08-02T02:11:06Z 2022 en
dc.description.abstract The recent popularity of E-cigarettes (ECs) is concerning, as the long-term health impacts of regular use are unknown. Recent evidence has associated EC use with biological consequences, such as inflammation, often a precursor for diseases. It is essential to understand EC particle deposition to characterise the health impacts of usage. In this study, CFD and 1D models were utilised to describe EC particle transport and deposition in the airways and the impact of particle size and vaping flow rate on global and regional deposition and deposition patterns. Based on commonly reported values, six mean particle sizes (range: 0.147 – 6.0 μm) and three flow rates were investigated (1.1, 1.7 and 2.4 L/min). The CFD simulation modelled the upper airways and the tracheobronchial tree (to the 5th generation), utilising realistic EC particle properties. The 1D model simulated particle transport and deposition in a full anatomically correct airway tree. Global particle deposition was low (< 0.5%) and increased with increasing flow rates. Deposition was highest in the upper airways, followed by the tracheobronchial and alveolar regions. The CFD model highlighted that the most deposition occurred in the left lower lobe while the least was in the right upper lobe. It showed clear deposition hot spots in the base of the mouth, back of the throat, and regions of curvature and bifurcations. The 1D model indicated that the deposition in the alveoli was very low except with large particles and high flow rates since all deposition occurred through sedimentation. Brownian motion was the key deposition mechanism for small particles (<1.0 μm), while sedimentation became dominant for larger particles (>2.5 μm). Impaction-related deposition remained low for all particle sizes. The 1D model appeared to underestimate deposition compared to the 3D model, likely because the 1D model simplified fluid flow and neglected secondary flows. Mathematical models were formulated, prescribing particle deposition as a function of size and vaping flow rate, which indicated a polynomial relationship between deposition and particle size. The outcome of this study may be helpful for future in vitro and in vivo investigations looking at the biological effects of EC aerosol dose.
dc.publisher ResearchSpace@Auckland en
dc.relation.ispartof Masters Thesis - University of Auckland en
dc.relation.isreferencedby UoA en
dc.rights Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated.
dc.rights.uri en
dc.title Assessing the Impact of E-cigarette Particle Size on Aerosol Transport and Deposition in the Lung
dc.type Thesis en Bioengineering The University of Auckland en Masters en 2022-06-29T10:05:16Z
dc.rights.holder Copyright: the author en

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