dc.contributor.advisor |
Burrowes, Kelly |
|
dc.contributor.advisor |
Suresh, Vinod |
|
dc.contributor.author |
Lal, Swashna |
|
dc.date.accessioned |
2022-08-02T02:11:06Z |
|
dc.date.available |
2022-08-02T02:11:06Z |
|
dc.date.issued |
2022 |
en |
dc.identifier.uri |
https://hdl.handle.net/2292/60642 |
|
dc.description.abstract |
The recent popularity of E-cigarettes (ECs) is concerning, as the long-term health impacts of
regular use are unknown. Recent evidence has associated EC use with biological
consequences, such as inflammation, often a precursor for diseases. It is essential to
understand EC particle deposition to characterise the health impacts of usage. In this study,
CFD and 1D models were utilised to describe EC particle transport and deposition in the
airways and the impact of particle size and vaping flow rate on global and regional deposition
and deposition patterns. Based on commonly reported values, six mean particle sizes (range:
0.147 – 6.0 μm) and three flow rates were investigated (1.1, 1.7 and 2.4 L/min). The CFD
simulation modelled the upper airways and the tracheobronchial tree (to the 5th generation),
utilising realistic EC particle properties. The 1D model simulated particle transport and
deposition in a full anatomically correct airway tree. Global particle deposition was low (<
0.5%) and increased with increasing flow rates. Deposition was highest in the upper airways,
followed by the tracheobronchial and alveolar regions. The CFD model highlighted that the
most deposition occurred in the left lower lobe while the least was in the right upper lobe. It
showed clear deposition hot spots in the base of the mouth, back of the throat, and regions
of curvature and bifurcations. The 1D model indicated that the deposition in the alveoli was
very low except with large particles and high flow rates since all deposition occurred through
sedimentation. Brownian motion was the key deposition mechanism for small particles (<1.0
μm), while sedimentation became dominant for larger particles (>2.5 μm). Impaction-related
deposition remained low for all particle sizes. The 1D model appeared to underestimate
deposition compared to the 3D model, likely because the 1D model simplified fluid flow and
neglected secondary flows. Mathematical models were formulated, prescribing particle
deposition as a function of size and vaping flow rate, which indicated a polynomial
relationship between deposition and particle size. The outcome of this study may be helpful
for future in vitro and in vivo investigations looking at the biological effects of EC aerosol dose. |
|
dc.publisher |
ResearchSpace@Auckland |
en |
dc.relation.ispartof |
Masters Thesis - University of Auckland |
en |
dc.relation.isreferencedby |
UoA |
en |
dc.rights |
Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. |
|
dc.rights.uri |
https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm |
en |
dc.rights.uri |
http://creativecommons.org/licenses/by-nc-nd/3.0/nz/ |
|
dc.title |
Assessing the Impact of E-cigarette Particle Size on Aerosol Transport and Deposition in the Lung |
|
dc.type |
Thesis |
en |
thesis.degree.discipline |
Bioengineering |
|
thesis.degree.grantor |
The University of Auckland |
en |
thesis.degree.level |
Masters |
en |
dc.date.updated |
2022-06-29T10:05:16Z |
|
dc.rights.holder |
Copyright: the author |
en |