dc.contributor.author |
Thygesen, Johan H |
|
dc.contributor.author |
Tomlinson, Christopher |
|
dc.contributor.author |
Hollings, Sam |
|
dc.contributor.author |
Mizani, Mehrdad A |
|
dc.contributor.author |
Handy, Alex |
|
dc.contributor.author |
Akbari, Ashley |
|
dc.contributor.author |
Banerjee, Amitava |
|
dc.contributor.author |
Cooper, Jennifer |
|
dc.contributor.author |
Lai, Alvina G |
|
dc.contributor.author |
Li, Kezhi |
|
dc.contributor.author |
Mateen, Bilal A |
|
dc.contributor.author |
Sattar, Naveed |
|
dc.contributor.author |
Sofat, Reecha |
|
dc.contributor.author |
Torralbo, Ana |
|
dc.contributor.author |
Wu, Honghan |
|
dc.contributor.author |
Wood, Angela |
|
dc.contributor.author |
Sterne, Jonathan AC |
|
dc.contributor.author |
Pagel, Christina |
|
dc.contributor.author |
Whiteley, William N |
|
dc.contributor.author |
Sudlow, Cathie |
|
dc.contributor.author |
Hemingway, Harry |
|
dc.contributor.author |
Denaxas, Spiros |
|
dc.contributor.author |
Longitudinal Health and Wellbeing COVID-19 National Core Study and the CVD-COVID-UK/COVID-IMPACT Consortium |
|
dc.coverage.spatial |
England |
|
dc.date.accessioned |
2022-08-15T03:36:18Z |
|
dc.date.available |
2022-08-15T03:36:18Z |
|
dc.date.issued |
2022-07 |
|
dc.identifier.citation |
(2022). Lancet Digital Health, 4(7), e542-e557. |
|
dc.identifier.issn |
2589-7500 |
|
dc.identifier.uri |
https://hdl.handle.net/2292/60795 |
|
dc.description.abstract |
<h4>Background</h4>Updatable estimates of COVID-19 onset, progression, and trajectories underpin pandemic mitigation efforts. To identify and characterise disease trajectories, we aimed to define and validate ten COVID-19 phenotypes from nationwide linked electronic health records (EHR) using an extensible framework.<h4>Methods</h4>In this cohort study, we used eight linked National Health Service (NHS) datasets for people in England alive on Jan 23, 2020. Data on COVID-19 testing, vaccination, primary and secondary care records, and death registrations were collected until Nov 30, 2021. We defined ten COVID-19 phenotypes reflecting clinically relevant stages of disease severity and encompassing five categories: positive SARS-CoV-2 test, primary care diagnosis, hospital admission, ventilation modality (four phenotypes), and death (three phenotypes). We constructed patient trajectories illustrating transition frequency and duration between phenotypes. Analyses were stratified by pandemic waves and vaccination status.<h4>Findings</h4>Among 57 032 174 individuals included in the cohort, 13 990 423 COVID-19 events were identified in 7 244 925 individuals, equating to an infection rate of 12·7% during the study period. Of 7 244 925 individuals, 460 737 (6·4%) were admitted to hospital and 158 020 (2·2%) died. Of 460 737 individuals who were admitted to hospital, 48 847 (10·6%) were admitted to the intensive care unit (ICU), 69 090 (15·0%) received non-invasive ventilation, and 25 928 (5·6%) received invasive ventilation. Among 384 135 patients who were admitted to hospital but did not require ventilation, mortality was higher in wave 1 (23 485 [30·4%] of 77 202 patients) than wave 2 (44 220 [23·1%] of 191 528 patients), but remained unchanged for patients admitted to the ICU. Mortality was highest among patients who received ventilatory support outside of the ICU in wave 1 (2569 [50·7%] of 5063 patients). 15 486 (9·8%) of 158 020 COVID-19-related deaths occurred within 28 days of the first COVID-19 event without a COVID-19 diagnoses on the death certificate. 10 884 (6·9%) of 158 020 deaths were identified exclusively from mortality data with no previous COVID-19 phenotype recorded. We observed longer patient trajectories in wave 2 than wave 1.<h4>Interpretation</h4>Our analyses illustrate the wide spectrum of disease trajectories as shown by differences in incidence, survival, and clinical pathways. We have provided a modular analytical framework that can be used to monitor the impact of the pandemic and generate evidence of clinical and policy relevance using multiple EHR sources.<h4>Funding</h4>British Heart Foundation Data Science Centre, led by Health Data Research UK. |
|
dc.format.medium |
Print-Electronic |
|
dc.language |
eng |
|
dc.publisher |
Elsevier |
|
dc.relation.ispartofseries |
The Lancet. Digital health |
|
dc.rights |
Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. |
|
dc.rights.uri |
https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm |
|
dc.rights.uri |
https://creativecommons.org/licenses/by/4.0/ |
|
dc.subject |
Longitudinal Health and Wellbeing COVID-19 National Core Study and the CVD-COVID-UK/COVID-IMPACT Consortium |
|
dc.subject |
Humans |
|
dc.subject |
Cohort Studies |
|
dc.subject |
State Medicine |
|
dc.subject |
England |
|
dc.subject |
Electronic Health Records |
|
dc.subject |
COVID-19 |
|
dc.subject |
SARS-CoV-2 |
|
dc.subject |
COVID-19 Testing |
|
dc.subject |
Clinical Research |
|
dc.subject |
Health Services |
|
dc.subject |
Patient Safety |
|
dc.subject |
2 Aetiology |
|
dc.subject |
2.4 Surveillance and distribution |
|
dc.subject |
Infection |
|
dc.subject |
3 Good Health and Well Being |
|
dc.title |
COVID-19 trajectories among 57 million adults in England: a cohort study using electronic health records. |
|
dc.type |
Journal Article |
|
dc.identifier.doi |
10.1016/s2589-7500(22)00091-7 |
|
pubs.issue |
7 |
|
pubs.begin-page |
e542 |
|
pubs.volume |
4 |
|
dc.date.updated |
2022-07-14T20:35:08Z |
|
dc.rights.holder |
Copyright: The authors |
en |
dc.identifier.pmid |
35690576 (pubmed) |
|
pubs.author-url |
https://www.ncbi.nlm.nih.gov/pubmed/35690576 |
|
pubs.end-page |
e557 |
|
pubs.publication-status |
Published |
|
dc.rights.accessrights |
http://purl.org/eprint/accessRights/OpenAccess |
en |
pubs.subtype |
Research Support, Non-U.S. Gov't |
|
pubs.subtype |
research-article |
|
pubs.subtype |
Journal Article |
|
pubs.elements-id |
911079 |
|
pubs.org-id |
Medical and Health Sciences |
|
pubs.org-id |
Population Health |
|
dc.identifier.eissn |
2589-7500 |
|
dc.identifier.pii |
S2589-7500(22)00091-7 |
|
pubs.record-created-at-source-date |
2022-07-15 |
|
pubs.online-publication-date |
2022-07 |
|