Epipyrone A, a Broad-Spectrum Antifungal Compound Produced by Epicoccum nigrum ICMP 19927.

Lee, Alex J; Cadelis, Melissa M; Kim, Sang H; Swift, Simon; Copp, Brent R; Villas-Boas, Silas G

dc.contributor.author	Lee, Alex J
dc.contributor.author	Cadelis, Melissa M
dc.contributor.author	Kim, Sang H
dc.contributor.author	Swift, Simon
dc.contributor.author	Copp, Brent R
dc.contributor.author	Villas-Boas, Silas G
dc.coverage.spatial	Switzerland
dc.date.accessioned	2022-08-17T23:50:39Z
dc.date.available	2022-08-17T23:50:39Z
dc.date.issued	2020-12-18
dc.identifier.citation	(2020). Molecules, 25(24), E5997-.
dc.identifier.issn	1420-3049
dc.identifier.uri	https://hdl.handle.net/2292/60845
dc.description.abstract	We have isolated a filamentous fungus that actively secretes a pigmented exudate when growing on agar plates. The fungus was identified as being a strain of Epicoccum nigrum. The fungal exudate presented strong antifungal activity against both yeasts and filamentous fungi, and inhibited the germination of fungal spores. The chemical characterization of the exudate showed that the pigmented molecule presenting antifungal activity is the disalt of epipyrone A-a water-soluble polyene metabolite with a molecular mass of 612.29 and maximal UV-Vis absorbance at 428 nm. This antifungal compound showed excellent stability to different temperatures and neutral to alkaline pH.
dc.format.medium	Electronic
dc.language	eng
dc.publisher	MDPI
dc.relation.ispartofseries	Molecules (Basel, Switzerland)
dc.rights	Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher.
dc.rights.uri	https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm
dc.rights.uri	https://creativecommons.org/licenses/by/4.0/
dc.subject	Fungi
dc.subject	Ascomycota
dc.subject	Spores, Fungal
dc.subject	Yeasts
dc.subject	Antifungal Agents
dc.subject	Spectrophotometry, Ultraviolet
dc.subject	Magnetic Resonance Spectroscopy
dc.subject	Microbial Sensitivity Tests
dc.subject	antibiotic
dc.subject	antimicrobial
dc.subject	bioactives
dc.subject	fungicide
dc.subject	pigment
dc.subject	polyenes
dc.subject	yeast
dc.subject	Science & Technology
dc.subject	Life Sciences & Biomedicine
dc.subject	Physical Sciences
dc.subject	Biochemistry & Molecular Biology
dc.subject	Chemistry, Multidisciplinary
dc.subject	Chemistry
dc.subject	SECONDARY METABOLITE
dc.subject	BOTRYTIS-CINEREA
dc.subject	NATURAL-PRODUCTS
dc.subject	OREVACTAENE
dc.subject	DERIVATIVES
dc.subject	INHIBITOR
dc.subject	EPIRODIN
dc.subject	CULTURE
dc.subject	PROTEIN
dc.subject	ACID
dc.subject	0304 Medicinal and Biomolecular Chemistry
dc.subject	0305 Organic Chemistry
dc.subject	0307 Theoretical and Computational Chemistry
dc.title	Epipyrone A, a Broad-Spectrum Antifungal Compound Produced by Epicoccum nigrum ICMP 19927.
dc.type	Journal Article
dc.identifier.doi	10.3390/molecules25245997
pubs.issue	24
pubs.begin-page	E5997
pubs.volume	25
dc.date.updated	2022-07-31T01:09:35Z
dc.rights.holder	Copyright: The authors	en
dc.identifier.pmid	33352899 (pubmed)
pubs.author-url	https://www.ncbi.nlm.nih.gov/pubmed/33352899
pubs.publication-status	Published
dc.rights.accessrights	http://purl.org/eprint/accessRights/OpenAccess	en
pubs.subtype	IM
pubs.subtype	research-article
pubs.subtype	Journal Article
pubs.elements-id	833188
pubs.org-id	Medical and Health Sciences
pubs.org-id	Science
pubs.org-id	Chemistry
pubs.org-id	Science Research
pubs.org-id	Medical Sciences
pubs.org-id	Molecular Medicine
pubs.org-id	Maurice Wilkins Centre (2010-2014)
dc.identifier.eissn	1420-3049
dc.identifier.pii	molecules25245997
pubs.number	ARTN 5997
pubs.record-created-at-source-date	2022-07-31
pubs.online-publication-date	2020-12-18