dc.contributor.author |
Shim, Vickie |
|
dc.contributor.author |
Tayebi, Maryam |
|
dc.contributor.author |
Kwon, Eryn |
|
dc.contributor.author |
Guild, Sarah-Jane |
|
dc.contributor.author |
Scadeng, Miriam |
|
dc.contributor.author |
Dubowitz, David |
|
dc.contributor.author |
McBryde, Fiona |
|
dc.contributor.author |
Rosset, Samuel |
|
dc.contributor.author |
Wang, Alan |
|
dc.contributor.author |
Fernandez, Justin |
|
dc.contributor.author |
Li, Shaofan |
|
dc.contributor.author |
Holdsworth, Samantha |
|
dc.date.accessioned |
2022-09-21T03:21:32Z |
|
dc.date.available |
2022-09-21T03:21:32Z |
|
dc.date.issued |
2022-07-12 |
|
dc.identifier.citation |
(2022). Engineering with Computers: an international journal for simulation-based engineering, 1-13. |
|
dc.identifier.issn |
0177-0667 |
|
dc.identifier.uri |
https://hdl.handle.net/2292/61369 |
|
dc.description.abstract |
<jats:title>Abstract</jats:title><jats:p>Traumatic brain injury (TBI) is a leading cause of death and disability. The way mechanical impact is transferred to the brain has been shown to be a major determinant for structural damage and subsequent pathological sequalae. Although finite element (FE) models have been used extensively in the investigation of various aspects of TBI and have been instrumental in characterising a TBI injury threshold and the pattern of diffuse axonal injuries, subject-specific analysis has been difficult to perform due to the complexity of brain structures and its material properties. We have developed an efficient computational pipeline that can generate subject-specific FE models of the brain made up of conforming hexahedral elements directly from advanced MRI scans. This pipeline was applied and validated in our sheep model of TBI. Our FE model of the sheep brain accurately predicted the damage pattern seen on post-impact MRI scans. Furthermore, our model also showed a complex time-varying strain distribution pattern, which was not present in the homogeneous model without subject-specific material descriptions. To our knowledge, this is the first fully subject-specific FE model of the sheep brain able to predict structural damage after a head impact. The pipeline developed has the potential to augment the analysis of human brain MRI scans to detect changes in brain structures and function after TBI.</jats:p> |
|
dc.language |
en |
|
dc.publisher |
Springer Nature |
|
dc.relation.ispartofseries |
Engineering with Computers |
|
dc.rights |
Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. |
|
dc.rights.uri |
https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm |
|
dc.rights.uri |
https://creativecommons.org/licenses/by/4.0/ |
|
dc.subject |
Injury - Trauma - (Head and Spine) |
|
dc.subject |
Injury (total) Accidents/Adverse Effects |
|
dc.subject |
Bioengineering |
|
dc.subject |
Biomedical Imaging |
|
dc.subject |
Brain Disorders |
|
dc.subject |
Neurosciences |
|
dc.subject |
Injury - Traumatic brain injury |
|
dc.subject |
Neurological |
|
dc.subject |
Injuries and accidents |
|
dc.subject |
0102 Applied Mathematics |
|
dc.subject |
0801 Artificial Intelligence and Image Processing |
|
dc.subject |
0802 Computation Theory and Mathematics |
|
dc.title |
Combining advanced magnetic resonance imaging (MRI) with finite element (FE) analysis for characterising subject-specific injury patterns in the brain after traumatic brain injury |
|
dc.type |
Journal Article |
|
dc.identifier.doi |
10.1007/s00366-022-01697-4 |
|
pubs.begin-page |
1 |
|
dc.date.updated |
2022-08-08T21:24:41Z |
|
dc.rights.holder |
Copyright: The authors |
en |
pubs.end-page |
13 |
|
pubs.publication-status |
Published online |
|
dc.rights.accessrights |
http://purl.org/eprint/accessRights/OpenAccess |
en |
pubs.subtype |
Journal Article |
|
pubs.elements-id |
912129 |
|
pubs.org-id |
Bioengineering Institute |
|
pubs.org-id |
Engineering |
|
pubs.org-id |
Medical and Health Sciences |
|
pubs.org-id |
Medical Sciences |
|
pubs.org-id |
Anatomy and Medical Imaging |
|
pubs.org-id |
Physiology Division |
|
pubs.org-id |
Engineering Science |
|
pubs.org-id |
ABI Associates |
|
dc.identifier.eissn |
1435-5663 |
|
pubs.record-created-at-source-date |
2022-08-09 |
|
pubs.online-publication-date |
2022-07-12 |
|