dc.contributor.author |
Lin, Luling |
|
dc.contributor.author |
Gamble, Greg D |
|
dc.contributor.author |
Crowther, Caroline A |
|
dc.contributor.author |
Bloomfield, Frank H |
|
dc.contributor.author |
Agosti, Massimo |
|
dc.contributor.author |
Atkinson, Stephanie A |
|
dc.contributor.author |
Biasini, Augusto |
|
dc.contributor.author |
Embleton, Nicholas D |
|
dc.contributor.author |
Lamy Filho, Fernando |
|
dc.contributor.author |
Fusch, Christoph |
|
dc.contributor.author |
Gianni, Maria L |
|
dc.contributor.author |
Kutman, Hayriye Gözde Kanmaz |
|
dc.contributor.author |
Koo, Winston |
|
dc.contributor.author |
Litmanovitz, Ita |
|
dc.contributor.author |
Morgan, Colin |
|
dc.contributor.author |
Mukhopadhyay, Kanya |
|
dc.contributor.author |
Neri, Erica |
|
dc.contributor.author |
Picaud, Jean-Charles |
|
dc.contributor.author |
Rochow, Niels |
|
dc.contributor.author |
Roggero, Paola |
|
dc.contributor.author |
Stroemmen, Kenneth |
|
dc.contributor.author |
Tan, Maw J |
|
dc.contributor.author |
Tandoi, Francesco M |
|
dc.contributor.author |
Wood, Claire L |
|
dc.contributor.author |
Zachariassen, Gitte |
|
dc.contributor.author |
Harding, Jane E |
|
dc.coverage.spatial |
Switzerland |
|
dc.date.accessioned |
2022-09-27T03:23:10Z |
|
dc.date.available |
2022-09-27T03:23:10Z |
|
dc.date.issued |
2022-01-17 |
|
dc.identifier.citation |
(2022). Nutrients, 14(2), 392-. |
|
dc.identifier.issn |
2072-6643 |
|
dc.identifier.uri |
https://hdl.handle.net/2292/61458 |
|
dc.description.abstract |
Neonatal nutritional supplements may improve early growth for infants born small, but effects on long-term growth are unclear and may differ by sex. We assessed the effects of early macronutrient supplements on later growth. We searched databases and clinical trials registers from inception to April 2019. Participant-level data from randomised trials were included if the intention was to increase macronutrient intake to improve growth or development of infants born preterm or small-for-gestational-age. Co-primary outcomes were cognitive impairment and metabolic risk. Supplementation did not alter BMI in childhood (kg/m2: adjusted mean difference (aMD) -0.11[95% CI -0.47, 0.25], p = 0.54; 3 trials, n = 333). Supplementation increased length (cm: aMD 0.37[0.01, 0.72], p = 0.04; 18 trials, n = 2008) and bone mineral content (g: aMD 10.22[0.52, 19.92], p = 0.04; 6 trials, n = 313) in infancy, but not at older ages. There were no differences between supplemented and unsupplemented groups for other outcomes. In subgroup analysis, supplementation increased the height z-score in male toddlers (aMD 0.20[0.02, 0.37], p = 0.03; 10 trials, n = 595) but not in females, and no significant sex interaction was observed (p = 0.21). Macronutrient supplementation for infants born small may not alter BMI in childhood. Supplementation increased growth in infancy, but these effects did not persist in later life. The effects did not differ between boys and girls. |
|
dc.format.medium |
Electronic |
|
dc.language |
eng |
|
dc.publisher |
MDPI |
|
dc.relation.ispartofseries |
Nutrients |
|
dc.rights |
Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. |
|
dc.rights.uri |
https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm |
|
dc.rights.uri |
https://creativecommons.org/licenses/by/4.0/ |
|
dc.subject |
Humans |
|
dc.subject |
Body Mass Index |
|
dc.subject |
Body Height |
|
dc.subject |
Treatment Outcome |
|
dc.subject |
Follow-Up Studies |
|
dc.subject |
Sex Factors |
|
dc.subject |
Bone Density |
|
dc.subject |
Dietary Supplements |
|
dc.subject |
Infant, Newborn |
|
dc.subject |
Infant, Small for Gestational Age |
|
dc.subject |
Infant, Premature |
|
dc.subject |
Female |
|
dc.subject |
Male |
|
dc.subject |
Infant Nutritional Physiological Phenomena |
|
dc.subject |
Nutrients |
|
dc.subject |
growth |
|
dc.subject |
individual participants data meta-analysis |
|
dc.subject |
macronutrient supplementation |
|
dc.subject |
preterm infants |
|
dc.subject |
small-for-gestational-age infants |
|
dc.subject |
systematic review |
|
dc.subject |
Nutrition |
|
dc.subject |
Perinatal Period - Conditions Originating in Perinatal Period |
|
dc.subject |
Infant Mortality |
|
dc.subject |
Pediatric |
|
dc.subject |
Clinical Trials and Supportive Activities |
|
dc.subject |
Preterm, Low Birth Weight and Health of the Newborn |
|
dc.subject |
Clinical Research |
|
dc.subject |
Prevention |
|
dc.subject |
Reproductive health and childbirth |
|
dc.subject |
Science & Technology |
|
dc.subject |
Life Sciences & Biomedicine |
|
dc.subject |
Nutrition & Dietetics |
|
dc.subject |
FOR-GESTATIONAL-AGE |
|
dc.subject |
LOW-BIRTH-WEIGHT |
|
dc.subject |
HUMAN-MILK |
|
dc.subject |
IGF-I |
|
dc.subject |
FORMULA |
|
dc.subject |
LEPTIN |
|
dc.subject |
GAIN |
|
dc.subject |
REQUIREMENTS |
|
dc.subject |
INCOME |
|
dc.subject |
0908 Food Sciences |
|
dc.subject |
1111 Nutrition and Dietetics |
|
dc.title |
Sex-Specific Effects of Nutritional Supplements for Infants Born Early or Small: An Individual Participant Data Meta-Analysis (ESSENCE IPD-MA) II: Growth. |
|
dc.type |
Journal Article |
|
dc.identifier.doi |
10.3390/nu14020392 |
|
pubs.issue |
2 |
|
pubs.begin-page |
392 |
|
pubs.volume |
14 |
|
dc.date.updated |
2022-08-05T00:18:44Z |
|
dc.rights.holder |
Copyright: The authors |
en |
dc.identifier.pmid |
35057573 (pubmed) |
|
pubs.author-url |
https://www.ncbi.nlm.nih.gov/pubmed/35057573 |
|
pubs.publication-status |
Published |
|
dc.rights.accessrights |
http://purl.org/eprint/accessRights/OpenAccess |
en |
pubs.subtype |
Meta-Analysis |
|
pubs.subtype |
IM |
|
pubs.subtype |
Systematic Review |
|
pubs.subtype |
review-article |
|
pubs.subtype |
Journal Article |
|
pubs.elements-id |
880549 |
|
pubs.org-id |
Liggins Institute |
|
pubs.org-id |
Medical and Health Sciences |
|
pubs.org-id |
School of Medicine |
|
pubs.org-id |
Medicine Department |
|
pubs.org-id |
LiFePATH |
|
dc.identifier.eissn |
2072-6643 |
|
dc.identifier.pii |
nu14020392 |
|
pubs.number |
ARTN 392 |
|
pubs.record-created-at-source-date |
2022-08-05 |
|
pubs.online-publication-date |
2022-01-17 |
|