Sex-Specific Effects of Nutritional Supplements for Infants Born Early or Small: An Individual Participant Data Meta-Analysis (ESSENCE IPD-MA) II: Growth.

Show simple item record Lin, Luling Gamble, Greg D Crowther, Caroline A Bloomfield, Frank H Agosti, Massimo Atkinson, Stephanie A Biasini, Augusto Embleton, Nicholas D Lamy Filho, Fernando Fusch, Christoph Gianni, Maria L Kutman, Hayriye Gözde Kanmaz Koo, Winston Litmanovitz, Ita Morgan, Colin Mukhopadhyay, Kanya Neri, Erica Picaud, Jean-Charles Rochow, Niels Roggero, Paola Stroemmen, Kenneth Tan, Maw J Tandoi, Francesco M Wood, Claire L Zachariassen, Gitte Harding, Jane E
dc.coverage.spatial Switzerland 2022-09-27T03:23:10Z 2022-09-27T03:23:10Z 2022-01-17
dc.identifier.citation (2022). Nutrients, 14(2), 392-.
dc.identifier.issn 2072-6643
dc.description.abstract Neonatal nutritional supplements may improve early growth for infants born small, but effects on long-term growth are unclear and may differ by sex. We assessed the effects of early macronutrient supplements on later growth. We searched databases and clinical trials registers from inception to April 2019. Participant-level data from randomised trials were included if the intention was to increase macronutrient intake to improve growth or development of infants born preterm or small-for-gestational-age. Co-primary outcomes were cognitive impairment and metabolic risk. Supplementation did not alter BMI in childhood (kg/m2: adjusted mean difference (aMD) -0.11[95% CI -0.47, 0.25], p = 0.54; 3 trials, n = 333). Supplementation increased length (cm: aMD 0.37[0.01, 0.72], p = 0.04; 18 trials, n = 2008) and bone mineral content (g: aMD 10.22[0.52, 19.92], p = 0.04; 6 trials, n = 313) in infancy, but not at older ages. There were no differences between supplemented and unsupplemented groups for other outcomes. In subgroup analysis, supplementation increased the height z-score in male toddlers (aMD 0.20[0.02, 0.37], p = 0.03; 10 trials, n = 595) but not in females, and no significant sex interaction was observed (p = 0.21). Macronutrient supplementation for infants born small may not alter BMI in childhood. Supplementation increased growth in infancy, but these effects did not persist in later life. The effects did not differ between boys and girls.
dc.format.medium Electronic
dc.language eng
dc.publisher MDPI
dc.relation.ispartofseries Nutrients
dc.rights Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher.
dc.subject Humans
dc.subject Body Mass Index
dc.subject Body Height
dc.subject Treatment Outcome
dc.subject Follow-Up Studies
dc.subject Sex Factors
dc.subject Bone Density
dc.subject Dietary Supplements
dc.subject Infant, Newborn
dc.subject Infant, Small for Gestational Age
dc.subject Infant, Premature
dc.subject Female
dc.subject Male
dc.subject Infant Nutritional Physiological Phenomena
dc.subject Nutrients
dc.subject growth
dc.subject individual participants data meta-analysis
dc.subject macronutrient supplementation
dc.subject preterm infants
dc.subject small-for-gestational-age infants
dc.subject systematic review
dc.subject Nutrition
dc.subject Perinatal Period - Conditions Originating in Perinatal Period
dc.subject Infant Mortality
dc.subject Pediatric
dc.subject Clinical Trials and Supportive Activities
dc.subject Preterm, Low Birth Weight and Health of the Newborn
dc.subject Clinical Research
dc.subject Prevention
dc.subject Reproductive health and childbirth
dc.subject Science & Technology
dc.subject Life Sciences & Biomedicine
dc.subject Nutrition & Dietetics
dc.subject HUMAN-MILK
dc.subject IGF-I
dc.subject FORMULA
dc.subject LEPTIN
dc.subject GAIN
dc.subject INCOME
dc.subject 0908 Food Sciences
dc.subject 1111 Nutrition and Dietetics
dc.title Sex-Specific Effects of Nutritional Supplements for Infants Born Early or Small: An Individual Participant Data Meta-Analysis (ESSENCE IPD-MA) II: Growth.
dc.type Journal Article
dc.identifier.doi 10.3390/nu14020392
pubs.issue 2
pubs.begin-page 392
pubs.volume 14 2022-08-05T00:18:44Z
dc.rights.holder Copyright: The authors en
dc.identifier.pmid 35057573 (pubmed)
pubs.publication-status Published
dc.rights.accessrights en
pubs.subtype Meta-Analysis
pubs.subtype IM
pubs.subtype Systematic Review
pubs.subtype review-article
pubs.subtype Journal Article
pubs.elements-id 880549 Liggins Institute Medical and Health Sciences School of Medicine Medicine Department LiFePATH
dc.identifier.eissn 2072-6643
dc.identifier.pii nu14020392
pubs.number ARTN 392
pubs.record-created-at-source-date 2022-08-05 2022-01-17

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