Immunization with adenoviral vectors carrying recombinant IL-12 and E7 enhanced the antitumor immunity to human papillomavirus 16-associated tumor.

Jin, Hyun Sun; Park, EK; Lee, JM; NamKoong, SE; Kim, DG; Lee, YJ; Jun, HJ; Han, BD; Bae, SM; Ahn, WS

dc.contributor.author	Jin, Hyun Sun	en
dc.contributor.author	Park, EK	en
dc.contributor.author	Lee, JM	en
dc.contributor.author	NamKoong, SE	en
dc.contributor.author	Kim, DG	en
dc.contributor.author	Lee, YJ	en
dc.contributor.author	Jun, HJ	en
dc.contributor.author	Han, BD	en
dc.contributor.author	Bae, SM	en
dc.contributor.author	Ahn, WS	en
dc.coverage.spatial	United States	en
dc.date.accessioned	2011-02-03T02:20:27Z	en
dc.date.issued	2005-05	en
dc.identifier.citation	Gynecol Oncol 97(2):559-567 May 2005	en
dc.identifier.issn	0090-8258	en
dc.identifier.uri	http://hdl.handle.net/2292/6209	en
dc.description.abstract	Human papillomavirus (HPV) infection play a significant role in cervical carcinogenesis, and HPV oncoprotein E7 has important functions in the formation and maintenance of cervical cancers. Interleukin-12 (IL-12) has been reported to induce cellular immune responses, and has also been demonstrated to suppress the growth of tumors and the expression of E7. Here, we investigate the utility of adenovirus E7 (AdE7) and adenovirus IL-12 (AdIL-12) for protection against TC-1 tumor using an animal model.	en
dc.language	eng	en
dc.relation.ispartofseries	Gynecol Oncol	en
dc.rights	Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. Details obtained from http://www.sherpa.ac.uk/romeo/issn/0090-8258/	en
dc.rights.uri	https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm	en
dc.subject	Adenoviridae	en
dc.subject	Animals	en
dc.subject	CD4-Positive T-Lymphocytes	en
dc.subject	CD8-Positive T-Lymphocytes	en
dc.subject	Cell Line, Tumor	en
dc.subject	Female	en
dc.subject	Humans	en
dc.subject	Immunoglobulin G	en
dc.subject	Interleukin-12	en
dc.subject	Lung Neoplasms	en
dc.subject	Mice	en
dc.subject	Mice, Inbred C57BL	en
dc.subject	Oncogene Proteins, Viral	en
dc.subject	Papillomavirus E7 Proteins	en
dc.subject	Recombinant Proteins	en
dc.subject	T-Lymphocytes, Cytotoxic	en
dc.subject	Transfection	en
dc.subject	Uterine Cervical Neoplasms	en
dc.title	Immunization with adenoviral vectors carrying recombinant IL-12 and E7 enhanced the antitumor immunity to human papillomavirus 16-associated tumor.	en
dc.type	Journal Article	en
dc.identifier.doi	10.1016/j.ygyno.2005.01.046	en
pubs.issue	2	en
pubs.begin-page	559	en
pubs.volume	97	en
dc.rights.holder	Copyright: 2005 Elsevier Inc.	en
dc.identifier.pmid	15863160	en
pubs.author-url	http://www.ncbi.nlm.nih.gov/pubmed/15863160	en
pubs.end-page	567	en
dc.rights.accessrights	http://purl.org/eprint/accessRights/RestrictedAccess	en
pubs.subtype	Article	en
pubs.elements-id	159630	en
dc.identifier.pii	S0090-8258(05)00112-5	en
pubs.record-created-at-source-date	2013-06-05	en
pubs.dimensions-id	15863160	en