dc.contributor.author |
Niu, Yun |
|
dc.contributor.author |
Wang, Baoguang |
|
dc.contributor.author |
Zhou, Li |
|
dc.contributor.author |
Ma, Changyang |
|
dc.contributor.author |
Waterhouse, Geoffrey IN |
|
dc.contributor.author |
Liu, Zhenhua |
|
dc.contributor.author |
Ahmed, Adel F |
|
dc.contributor.author |
Sun-Waterhouse, Dongxiao |
|
dc.contributor.author |
Kang, Wenyi |
|
dc.coverage.spatial |
Switzerland |
|
dc.date.accessioned |
2022-12-16T01:24:03Z |
|
dc.date.available |
2022-12-16T01:24:03Z |
|
dc.date.issued |
2021-01 |
|
dc.identifier.citation |
(2021). Frontiers in Nutrition, 8, 722813-. |
|
dc.identifier.issn |
2296-861X |
|
dc.identifier.uri |
https://hdl.handle.net/2292/62167 |
|
dc.description.abstract |
Nutrients can be considered as functional foods, which exert physiological benefits on immune system. The seeds of <i>Nigella sativa</i>, which have many active constituents, are mainly used for medicine, food spice, and nutritional supplements in Egypt. Much attention has been paid to <i>N. sativa</i> seeds for their anticancer, antibacterial, anti-inflammatory, and immune properties. However, their active constituents and mechanisms underlying functions from <i>N. sativa</i> seeds is unclear. Thus, the bioactive constituents with immune regulation in <i>N. sativa</i> seeds were systematically studied. A new compound (3-methoxythymol-6-<i>O</i>-β-D-apiofuranosyl-(1→6)-β-D-glucopyranoside <b>1</b>) and 11 known compounds (<b>2-12</b>) were separated from the <i>N. sativa</i> seeds by chromatographic methods. Their structures were then elucidated by spectroscopic analysis of MS, UV, IR, <sup>1</sup>H-, and <sup>13</sup>C-NMR. Furthermore, immunomodulatory effects of those compounds in RAW 264.7 cells were evaluated by phagocytosis, nitric oxide (NO) and cytokine release, related mRNA transcription, and key proteins expression <i>in vitro</i>. Monosaccharide derivatives, Ethyl-α-D-furaarabinose (<b>5</b>), and Ethyl-β-D-fructofuranoside (<b>8</b>) were shown to played bidirectional regulatory roles in immunity and anti-inflammation through the regulation of nuclear factor-κB (NF-κB) signaling pathways. The results showed the active compounds and mechanisms of immune regulation in <i>N. sativa</i>, thus indicating that <i>N. sativa</i> seeds could be used as dietary supplements in immunomodulation. |
|
dc.format.medium |
Electronic-eCollection |
|
dc.language |
eng |
|
dc.publisher |
Frontiers |
|
dc.relation.ispartofseries |
Frontiers in nutrition |
|
dc.rights |
Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. |
|
dc.rights.uri |
https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm |
|
dc.rights.uri |
https://creativecommons.org/licenses/by/4.0/ |
|
dc.subject |
Nigella sativa |
|
dc.subject |
RAW264.7 |
|
dc.subject |
anti-inflammatory |
|
dc.subject |
immune |
|
dc.subject |
monosaccharide derivatives |
|
dc.subject |
monoterpene glucoside |
|
dc.subject |
Complementary and Integrative Health |
|
dc.subject |
Nutrition |
|
dc.subject |
3.3 Nutrition and chemoprevention |
|
dc.subject |
3 Prevention of disease and conditions, and promotion of well-being |
|
dc.subject |
Cancer |
|
dc.subject |
Inflammatory and immune system |
|
dc.subject |
Cardiovascular |
|
dc.subject |
Science & Technology |
|
dc.subject |
Life Sciences & Biomedicine |
|
dc.subject |
Nutrition & Dietetics |
|
dc.subject |
NF-KAPPA-B |
|
dc.subject |
OXIDATIVE STRESS |
|
dc.subject |
THYMOQUINONE |
|
dc.subject |
INFLAMMATION |
|
dc.subject |
POLYSACCHARIDES |
|
dc.subject |
ANTIOXIDANT |
|
dc.subject |
MACROPHAGES |
|
dc.subject |
HEALTH |
|
dc.subject |
1001 Agricultural Biotechnology |
|
dc.subject |
1111 Nutrition and Dietetics |
|
dc.title |
<i>Nigella sativa</i>: A Dietary Supplement as an Immune-Modulator on the Basis of Bioactive Components. |
|
dc.type |
Journal Article |
|
dc.identifier.doi |
10.3389/fnut.2021.722813 |
|
pubs.begin-page |
722813 |
|
pubs.volume |
8 |
|
dc.date.updated |
2022-11-27T06:44:18Z |
|
dc.rights.holder |
Copyright: The authors |
en |
dc.identifier.pmid |
34485368 (pubmed) |
|
pubs.author-url |
https://www.ncbi.nlm.nih.gov/pubmed/34485368 |
|
pubs.publication-status |
Published |
|
dc.rights.accessrights |
http://purl.org/eprint/accessRights/OpenAccess |
en |
pubs.subtype |
research-article |
|
pubs.subtype |
Journal Article |
|
pubs.elements-id |
866406 |
|
pubs.org-id |
Science |
|
pubs.org-id |
Chemistry |
|
dc.identifier.eissn |
2296-861X |
|
pubs.number |
ARTN 722813 |
|
pubs.record-created-at-source-date |
2022-11-27 |
|
pubs.online-publication-date |
2021-08-17 |
|