dc.contributor.author |
Braakhuis, Andrea J |
|
dc.contributor.author |
Donaldson, Caitlin I |
|
dc.contributor.author |
Lim, Julie C |
|
dc.contributor.author |
Donaldson, Paul J |
|
dc.coverage.spatial |
Switzerland |
|
dc.date.accessioned |
2023-01-24T20:14:39Z |
|
dc.date.available |
2023-01-24T20:14:39Z |
|
dc.date.issued |
2019-05-27 |
|
dc.identifier.citation |
(2019). Nutrients, 11(5), E1186-. |
|
dc.identifier.issn |
2072-6643 |
|
dc.identifier.uri |
https://hdl.handle.net/2292/62550 |
|
dc.description.abstract |
Oxidative stress and the subsequent oxidative damage to lens proteins is a known causative factor in the initiation and progression of cataract formation, the leading cause of blindness in the world today. Due to the role of oxidative damage in the etiology of cataract, antioxidants have been prompted as therapeutic options to delay and/or prevent disease progression. However, many exogenous antioxidant interventions have to date produced mixed results as anti-cataract therapies. The aim of this review is to critically evaluate the efficacy of a sample of dietary and topical antioxidant interventions in the light of our current understanding of lens structure and function. Situated in the eye behind the blood-eye barrier, the lens receives it nutrients and antioxidants from the aqueous and vitreous humors. Furthermore, being a relatively large avascular tissue the lens cannot rely of passive diffusion alone to deliver nutrients and antioxidants to the distinctly different metabolic regions of the lens. We instead propose that the lens utilizes a unique internal microcirculation system to actively deliver antioxidants to these different regions, and that selecting antioxidants that can utilize this system is the key to developing novel nutritional therapies to delay the onset and progression of lens cataract. |
|
dc.format.medium |
Electronic |
|
dc.language |
eng |
|
dc.publisher |
MDPI |
|
dc.relation.ispartofseries |
Nutrients |
|
dc.rights |
Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. |
|
dc.rights.uri |
https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm |
|
dc.rights.uri |
reativecommons.org/licenses/by-nc/4.0/ |
|
dc.subject |
Lens, Crystalline |
|
dc.subject |
Animals |
|
dc.subject |
Humans |
|
dc.subject |
Cataract |
|
dc.subject |
Antioxidants |
|
dc.subject |
Diet |
|
dc.subject |
Risk Factors |
|
dc.subject |
Oxidative Stress |
|
dc.subject |
Nutritional Status |
|
dc.subject |
Nutritive Value |
|
dc.subject |
Dietary Supplements |
|
dc.subject |
Protective Factors |
|
dc.subject |
antioxidant supplements |
|
dc.subject |
dietary antioxidants |
|
dc.subject |
lens |
|
dc.subject |
Complementary and Integrative Health |
|
dc.subject |
Aging |
|
dc.subject |
Eye Disease and Disorders of Vision |
|
dc.subject |
Prevention |
|
dc.subject |
Nutrition |
|
dc.subject |
Science & Technology |
|
dc.subject |
Life Sciences & Biomedicine |
|
dc.subject |
Nutrition & Dietetics |
|
dc.subject |
AGE-RELATED CATARACT |
|
dc.subject |
GLUCOSE TRANSPORTERS GLUT1 |
|
dc.subject |
VITAMIN-C |
|
dc.subject |
RANDOMIZED-TRIAL |
|
dc.subject |
NUCLEAR CATARACT |
|
dc.subject |
MACULAR DEGENERATION |
|
dc.subject |
PROSPECTIVE COHORT |
|
dc.subject |
MOLECULAR CHARACTERIZATION |
|
dc.subject |
REDUCED GLUTATHIONE |
|
dc.subject |
NUTRIENT INTAKE |
|
dc.subject |
1113 Opthalmology and Optometry |
|
dc.subject |
0601 Biochemistry and Cell Biology |
|
dc.subject |
Biomedical |
|
dc.subject |
Basic Science |
|
dc.subject |
Complementary and Alternative Medicine |
|
dc.subject |
0908 Food Sciences |
|
dc.subject |
1111 Nutrition and Dietetics |
|
dc.title |
Nutritional Strategies to Prevent Lens Cataract: Current Status and Future Strategies. |
|
dc.type |
Journal Article |
|
dc.identifier.doi |
10.3390/nu11051186 |
|
pubs.issue |
5 |
|
pubs.begin-page |
E1186 |
|
pubs.volume |
11 |
|
dc.date.updated |
2022-12-02T17:32:16Z |
|
dc.rights.holder |
Copyright: The authors |
en |
dc.identifier.pmid |
31137834 (pubmed) |
|
pubs.author-url |
https://www.ncbi.nlm.nih.gov/pubmed/31137834 |
|
pubs.publication-status |
Published |
|
dc.rights.accessrights |
http://purl.org/eprint/accessRights/OpenAccess |
en |
pubs.subtype |
IM |
|
pubs.subtype |
review-article |
|
pubs.subtype |
Review |
|
pubs.subtype |
Journal Article |
|
pubs.elements-id |
774433 |
|
pubs.org-id |
Medical and Health Sciences |
|
pubs.org-id |
Medical Sciences |
|
pubs.org-id |
Nutrition |
|
dc.identifier.eissn |
2072-6643 |
|
dc.identifier.pii |
nu11051186 |
|
pubs.number |
ARTN 1186 |
|
pubs.record-created-at-source-date |
2022-12-03 |
|
pubs.online-publication-date |
2019-05-27 |
|