dc.contributor.advisor |
Slykerman, Rebecca |
|
dc.contributor.advisor |
Lovell, Amy |
|
dc.contributor.author |
Moreira Dos Santos, Sonia |
|
dc.date.accessioned |
2023-01-25T19:49:06Z |
|
dc.date.available |
2023-01-25T19:49:06Z |
|
dc.date.issued |
2022 |
en |
dc.identifier.uri |
https://hdl.handle.net/2292/62583 |
|
dc.description.abstract |
Upper respiratory tract infections (URTIs) are prevalent in children under five years
of age, globally, and in New Zealand. URTIs are one of the most prevalent acute self-limited
and benign illnesses seen in paediatric clinics, as well as the main cause of missed childcare
days. Children who attend childcare are three times as likely to suffer from a URTI in
comparison to those cared for at home. They are more susceptible to illnesses since their
immune systems are still maturing. Probiotics modulate the composition of gut microbial
species by maintaining a healthy balance and inhibiting the growth of potentially pathogenic
bacteria. The positive effects of probiotics have been widely employed to improve host health
and treat a variety of infectious and non-infectious diseases. They may be a possible
nutritional strategy to combat URTIs due to their favourable effects on the human immune
system. The aims of this study were to evaluate the efficacy of the probiotic Bifidobacterium
animalis HN019 (HN019), versus placebo, in reducing the number of days of URTIs
symptoms in children aged 12 months to 5 years attending childcare in New Zealand. The
HICCUP study was a randomised, double-blind, placebo-controlled trial. A total of 160
children were randomly assigned to either the intervention group, receiving capsules
containing probiotic HN019, in a dose of 9×109
colony forming units, or the placebo group,
who received placebo capsules every day for 12 weeks. There was no significant difference
in average number of illness days per week between the probiotic group (M = 1.20, SD =
1.07) and the placebo group (M = 1.19, SD = 1.01); t(df) = 131, p = 0.96. Consumption of
HN019, in a dose of 9×109
colony forming units per day did not reduce the number of days of
URTIs in children aged 12 months to 5 years attending childcare in New Zealand.
However, the impact of the COVID-19 lockdown reduced the number of circulating
viral illnesses, which may have contributed to the lack of a significant finding in this study.
Keywords: URTIs, Children, Childcare, Probiotic, Microbiota-Gut Brains |
|
dc.publisher |
ResearchSpace@Auckland |
en |
dc.relation.ispartof |
Masters Thesis - University of Auckland |
en |
dc.relation.isreferencedby |
UoA |
en |
dc.rights |
Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. |
|
dc.rights.uri |
https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm |
en |
dc.rights.uri |
http://creativecommons.org/licenses/by-nc-sa/3.0/nz/ |
|
dc.title |
Healthy Immunity in Children at Childcare Using Probiotics (HICCUP) Study |
|
dc.type |
Thesis |
en |
thesis.degree.discipline |
Psychology |
|
thesis.degree.grantor |
The University of Auckland |
en |
thesis.degree.level |
Masters |
en |
dc.date.updated |
2022-12-07T01:19:51Z |
|
dc.rights.holder |
Copyright: the author |
en |
dc.rights.accessrights |
http://purl.org/eprint/accessRights/OpenAccess |
en |