dc.contributor.author |
Lin, Luling |
|
dc.contributor.author |
St Clair, Sophie |
|
dc.contributor.author |
Gamble, Greg D |
|
dc.contributor.author |
Crowther, Caroline A |
|
dc.contributor.author |
Dixon, Lesley |
|
dc.contributor.author |
Bloomfield, Frank H |
|
dc.contributor.author |
Harding, Jane E |
|
dc.date.accessioned |
2023-02-02T03:16:41Z |
|
dc.date.available |
2023-02-02T03:16:41Z |
|
dc.date.issued |
2023-01 |
|
dc.identifier.citation |
Scientific reports 13(1):563 Jan 2023 |
|
dc.identifier.issn |
2045-2322 |
|
dc.identifier.uri |
https://hdl.handle.net/2292/62629 |
|
dc.description.abstract |
Exposure to low levels of nitrate in drinking water may have adverse reproductive effects. We reviewed evidence about the association between nitrate in drinking water and adverse reproductive outcomes published to November 2022. Randomized trials, cohort or case-control studies published in English that reported the relationship between nitrate intake from drinking water and the risk of perinatal outcomes were included. Random-effect models were used to pool data. Three cohort studies showed nitrate in drinking water is associated with an increased risk of preterm birth (odds ratio for 1 mg/L NO<sub>3</sub>-N increased (OR<sub>1</sub>) = 1.01, 95% CI 1.00, 1.01, I<sup>2</sup> = 23.9%, 5,014,487 participants; comparing the highest versus the lowest nitrate exposure groups pooled OR (OR<sub>p</sub>) = 1.05, 95% CI 1.01, 1.10, I<sup>2</sup> = 0%, 4,152,348 participants). Case-control studies showed nitrate in drinking water may be associated with the increased risk of neural tube defects OR<sub>1</sub> = 1.06, 95% CI 1.02, 1.10; 2 studies, 2196 participants; I<sup>2</sup> = 0%; and OR<sub>p</sub> = 1.51, 95% CI 1.12, 2.05; 3 studies, 1501 participants; I<sup>2</sup> = 0%). The evidence for an association between nitrate in drinking water and risk of small for gestational age infants, any birth defects, or any congenital heart defects was inconsistent. Increased nitrate in drinking water may be associated with an increased risk of preterm birth and some specific congenital anomalies. These findings warrant regular review as new evidence becomes available. |
|
dc.format.medium |
Electronic |
|
dc.publisher |
Springer Nature |
|
dc.rights |
Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. |
|
dc.rights.uri |
https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm |
|
dc.subject |
Pregnancy |
|
dc.subject |
Female |
|
dc.subject |
Infant, Newborn |
|
dc.subject |
Humans |
|
dc.subject |
Nitrates |
|
dc.subject |
Drinking Water |
|
dc.subject |
Premature Birth |
|
dc.subject |
Reproduction |
|
dc.subject |
Parturition |
|
dc.subject |
Perinatal Period - Conditions Originating in Perinatal Period |
|
dc.subject |
Infant Mortality |
|
dc.subject |
Pediatric |
|
dc.subject |
Preterm, Low Birth Weight and Health of the Newborn |
|
dc.subject |
Cardiovascular |
|
dc.subject |
Reproductive health and childbirth |
|
dc.subject |
3 Good Health and Well Being |
|
dc.title |
Nitrate contamination in drinking water and adverse reproductive and birth outcomes: a systematic review and meta-analysis. |
|
dc.type |
Journal Article |
|
dc.identifier.doi |
10.1038/s41598-022-27345-x |
|
pubs.begin-page |
563 |
|
pubs.volume |
13 |
|
dc.date.updated |
2023-01-21T03:41:43Z |
|
dc.rights.holder |
Copyright: The authors |
en |
pubs.author-url |
https://www.ncbi.nlm.nih.gov/pubmed/36631499 |
|
pubs.publication-status |
Published |
|
pubs.elements-id |
871165 |
|
pubs.org-id |
Liggins Institute |
|
pubs.org-id |
LiFePATH |
|
dc.identifier.eissn |
2045-2322 |
|
pubs.number |
563 |
|
pubs.record-created-at-source-date |
2023-01-21 |
|