dc.contributor.author |
Peng, Yang |
|
dc.contributor.author |
Hong, Jiwon |
|
dc.contributor.author |
Raftery, Daniel |
|
dc.contributor.author |
Xia, Qing |
|
dc.contributor.author |
Du, Dan |
|
dc.coverage.spatial |
Netherlands |
|
dc.date.accessioned |
2023-02-14T00:49:21Z |
|
dc.date.available |
2023-02-14T00:49:21Z |
|
dc.date.issued |
2021-07 |
|
dc.identifier.citation |
(2021). Biochimica et Biophysica Acta (BBA): Molecular Basis of Disease, 1867(7), 166123-. |
|
dc.identifier.issn |
0925-4439 |
|
dc.identifier.uri |
https://hdl.handle.net/2292/62815 |
|
dc.description.abstract |
Acute pancreatitis (AP) is one of the most common gastroenterological disorders requiring hospitalization and is associated with substantial morbidity and mortality. Metabolomics nowadays not only help us to understand cellular metabolism to a degree that was not previously obtainable, but also to reveal the importance of the metabolites in physiological control, disease onset and development. An in-depth understanding of metabolic phenotyping would be therefore crucial for accurate diagnosis, prognosis and precise treatment of AP. In this review, we summarized and addressed the metabolomics design and workflow in AP studies, as well as the results and analysis of the in-depth of research. Based on the metabolic profiling work in both clinical populations and experimental AP models, we described the metabolites with potential utility as biomarkers and the correlation between the altered metabolites and AP status. Moreover, the disturbed metabolic pathways correlated with biological function were discussed in the end. A practical understanding of current and emerging metabolomic approaches applicable to AP and use of the metabolite information presented will aid in designing robust metabolomics and biological experiments that result in identification of unique biomarkers and mechanisms, and ultimately enhanced clinical decision-making. |
|
dc.format.medium |
Print-Electronic |
|
dc.language |
eng |
|
dc.publisher |
Elsevier |
|
dc.relation.ispartofseries |
Biochimica et biophysica acta. Molecular basis of disease |
|
dc.rights |
Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. |
|
dc.rights.uri |
https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm |
|
dc.subject |
Animals |
|
dc.subject |
Humans |
|
dc.subject |
Pancreatitis |
|
dc.subject |
Disease Models, Animal |
|
dc.subject |
Metabolome |
|
dc.subject |
Biomarkers |
|
dc.subject |
Acute pancreatitis |
|
dc.subject |
Biomarker |
|
dc.subject |
Metabolic pathway |
|
dc.subject |
Metabolites |
|
dc.subject |
Metabolomics |
|
dc.subject |
4 Detection, screening and diagnosis |
|
dc.subject |
4.1 Discovery and preclinical testing of markers and technologies |
|
dc.subject |
3 Good Health and Well Being |
|
dc.subject |
Science & Technology |
|
dc.subject |
Life Sciences & Biomedicine |
|
dc.subject |
Biochemistry & Molecular Biology |
|
dc.subject |
Biophysics |
|
dc.subject |
Cell Biology |
|
dc.subject |
SPECTROMETRY-BASED METABOLOMICS |
|
dc.subject |
ACUTE NECROTIZING PANCREATITIS |
|
dc.subject |
PERSISTENT ORGAN FAILURE |
|
dc.subject |
MASS-SPECTROMETRY |
|
dc.subject |
LIQUID-CHROMATOGRAPHY |
|
dc.subject |
GALLSTONE PANCREATITIS |
|
dc.subject |
MULTIVARIATE-ANALYSIS |
|
dc.subject |
L-ORNITHINE |
|
dc.subject |
SERUM |
|
dc.subject |
0601 Biochemistry and Cell Biology |
|
dc.subject |
1101 Medical Biochemistry and Metabolomics |
|
dc.subject |
1103 Clinical Sciences |
|
dc.title |
Metabolomic-based clinical studies and murine models for acute pancreatitis disease: A review. |
|
dc.type |
Journal Article |
|
dc.identifier.doi |
10.1016/j.bbadis.2021.166123 |
|
pubs.issue |
7 |
|
pubs.begin-page |
166123 |
|
pubs.volume |
1867 |
|
dc.date.updated |
2023-01-05T01:14:02Z |
|
dc.rights.holder |
Copyright: The authors |
en |
dc.identifier.pmid |
33713791 (pubmed) |
|
pubs.author-url |
https://www.ncbi.nlm.nih.gov/pubmed/33713791 |
|
pubs.publication-status |
Published |
|
dc.rights.accessrights |
http://purl.org/eprint/accessRights/RetrictedAccess |
en |
pubs.subtype |
Research Support, Non-U.S. Gov't |
|
pubs.subtype |
Review |
|
pubs.subtype |
Journal Article |
|
pubs.elements-id |
846596 |
|
pubs.org-id |
Medical and Health Sciences |
|
pubs.org-id |
School of Medicine |
|
pubs.org-id |
Surgery Department |
|
dc.identifier.eissn |
1879-260X |
|
dc.identifier.pii |
S0925-4439(21)00056-9 |
|
pubs.number |
166123 |
|
pubs.record-created-at-source-date |
2023-01-05 |
|
pubs.online-publication-date |
2021-03-11 |
|