dc.contributor.author |
Menkes, DB |
|
dc.contributor.author |
Gallager, DW |
|
dc.contributor.author |
Reinhard, JF |
|
dc.contributor.author |
Aghajanian, GK |
|
dc.coverage.spatial |
Netherlands |
|
dc.date.accessioned |
2023-02-14T01:01:35Z |
|
dc.date.available |
2023-02-14T01:01:35Z |
|
dc.date.issued |
1983-08 |
|
dc.identifier.citation |
(1983). Brain Research, 272(1), 1-12. |
|
dc.identifier.issn |
0006-8993 |
|
dc.identifier.uri |
https://hdl.handle.net/2292/62816 |
|
dc.description.abstract |
Electrophysiological and radioligand binding methods were used to characterize noradrenergic denervation supersensitivity at alpha 1-adrenoceptors in rat thalamus. Denervation was accomplished either by intraventricular or intracerebral injection of the catecholamine neurotoxin 6-hydroxydopamine (6-OHDA). In the physiological studies, the sensitivity of single lateral geniculate neurons to norepinephrine, carbachol, and serotonin was compared in sham and lesioned animals various times after 6-OHDA. Conducted in parallel were radioligand binding studies in which the density and affinity of thalamic alpha 1-adrenoceptors were measured with the specific antagonist [3H]prazosin. The results indicate that denervation produces a selective increase in the sensitivity of geniculate neurons to alpha 1-adrenergic stimulation and a concomitant increase in alpha 1-adrenoceptor density and agonist affinity. |
|
dc.format.medium |
Print |
|
dc.language |
eng |
|
dc.publisher |
Elsevier |
|
dc.relation.ispartofseries |
Brain research |
|
dc.rights |
Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. |
|
dc.rights.uri |
https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm |
|
dc.subject |
Geniculate Bodies |
|
dc.subject |
Neurons |
|
dc.subject |
Animals |
|
dc.subject |
Rats |
|
dc.subject |
Norepinephrine |
|
dc.subject |
Carbachol |
|
dc.subject |
Serotonin |
|
dc.subject |
Hydroxydopamines |
|
dc.subject |
Oxidopamine |
|
dc.subject |
Quinazolines |
|
dc.subject |
Prazosin |
|
dc.subject |
Receptors, Adrenergic |
|
dc.subject |
Radioligand Assay |
|
dc.subject |
Denervation |
|
dc.subject |
Evoked Potentials |
|
dc.subject |
Male |
|
dc.subject |
Neurosciences |
|
dc.subject |
Brain Disorders |
|
dc.subject |
Science & Technology |
|
dc.subject |
Life Sciences & Biomedicine |
|
dc.subject |
Neurosciences & Neurology |
|
dc.subject |
1109 Neurosciences |
|
dc.subject |
Basic Science |
|
dc.subject |
1701 Psychology |
|
dc.subject |
1702 Cognitive Sciences |
|
dc.title |
Alpha 1-adrenoceptor denervation supersensitivity in brain: physiological and receptor binding studies. |
|
dc.type |
Journal Article |
|
dc.identifier.doi |
10.1016/0006-8993(83)90358-x |
|
pubs.issue |
1 |
|
pubs.begin-page |
1 |
|
pubs.volume |
272 |
|
dc.date.updated |
2023-01-05T23:39:25Z |
|
dc.rights.holder |
Copyright: The authors |
en |
dc.identifier.pmid |
6311335 (pubmed) |
|
pubs.author-url |
https://www.ncbi.nlm.nih.gov/pubmed/6311335 |
|
pubs.end-page |
12 |
|
pubs.publication-status |
Published |
|
dc.rights.accessrights |
http://purl.org/eprint/accessRights/RetrictedAccess |
en |
pubs.subtype |
Research Support, U.S. Gov't, P.H.S. |
|
pubs.subtype |
Research Support, Non-U.S. Gov't |
|
pubs.subtype |
Journal Article |
|
pubs.elements-id |
541339 |
|
pubs.org-id |
Medical and Health Sciences |
|
pubs.org-id |
School of Medicine |
|
pubs.org-id |
Psychological Medicine Dept |
|
dc.identifier.eissn |
1872-6240 |
|
dc.identifier.pii |
0006-8993(83)90358-X |
|
pubs.record-created-at-source-date |
2023-01-06 |
|