dc.contributor.author |
De Boo, HA |
en |
dc.contributor.author |
Eremia, Simona |
en |
dc.contributor.author |
Bloomfield, Francis |
en |
dc.contributor.author |
Oliver, Mark |
en |
dc.contributor.author |
Harding, Jane |
en |
dc.date.accessioned |
2011-02-03T02:29:24Z |
en |
dc.date.issued |
2008 |
en |
dc.identifier.citation |
AM J OBSTET GYNECOL 199(5): Article number 559.e1 Nov 2008 |
en |
dc.identifier.issn |
0002-9378 |
en |
dc.identifier.uri |
http://hdl.handle.net/2292/6297 |
en |
dc.description.abstract |
OBJECTIVE: This study was undertaken to investigate whether maternal growth hormone supplementation in pregnant sheep could reverse intrauterine growth restriction (IUGR) induced by placental embolization.STUDY DESIGN: Animals were randomized into control, intrauterine growth restriction + saline or intrauterine growth restriction + growth hormone (twice daily injections of 0.1 mg/kg growth hormone) groups. Intrauterine growth restriction was induced by twice daily placental embolization between 93 and 99 days' gestation, and treatment was from 100-128 days' gestation (term = 147 days' gestation).RESULTS: Embolization reduced fetal growth rate and body weight but increased brain-to-liver weight ratio. Growth hormone treatment significantly increased fetal growth rates and fat deposition, and improved fetal body weight and length, but not liver weight. Growth hormone treatment produced hydranencephalic brain lesions in some fetuses.CONCLUSION: Maternal growth hormone treatment partially reversed intrauterine growth restriction caused by placental insufficiency. However, the possible connection between growth hormone treatment and fetal brain injury requires further investigation |
en |
dc.language |
EN |
en |
dc.relation.ispartofseries |
American Journal of Obstetrics and Gynecology |
en |
dc.rights |
Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. Details obtained from http://www.sherpa.ac.uk/romeo/issn/0002-9378/ |
en |
dc.rights.uri |
https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm |
en |
dc.subject |
brain |
en |
dc.subject |
fetus |
en |
dc.subject |
growth hormone |
en |
dc.subject |
intrauterine growth restriction |
en |
dc.subject |
sheep |
en |
dc.subject |
OVERNOURISHED ADOLESCENT SHEEP |
en |
dc.subject |
FETAL-GROWTH |
en |
dc.subject |
FACTOR-I |
en |
dc.subject |
NUTRITIONAL SUPPLEMENTATION |
en |
dc.subject |
POSTNATAL-GROWTH |
en |
dc.subject |
NORMAL-PREGNANCY |
en |
dc.subject |
REDUCED DIET |
en |
dc.subject |
IGF-I |
en |
dc.subject |
INSULIN |
en |
dc.subject |
GLUCOSE |
en |
dc.title |
Treatment of intrauterine growth restriction with maternal growth hormone supplementation in sheep. |
en |
dc.type |
Journal Article |
en |
dc.identifier.doi |
10.1016/j.ajog.2008.04.035 |
en |
pubs.issue |
5 |
en |
pubs.begin-page |
559.e1 |
en |
pubs.volume |
199 |
en |
dc.rights.holder |
Copyright: 2008 Mosby, Inc. |
en |
dc.identifier.pmid |
18599015 |
en |
pubs.end-page |
559.e9 |
en |
dc.rights.accessrights |
http://purl.org/eprint/accessRights/RestrictedAccess |
en |
pubs.subtype |
Article |
en |
pubs.elements-id |
80681 |
en |
pubs.org-id |
Liggins Institute |
en |
pubs.org-id |
LiFePATH |
en |
pubs.record-created-at-source-date |
2010-09-01 |
en |
pubs.dimensions-id |
18599015 |
en |