Effects of twinning and periconceptional undernutrition on late-gestation hypothalamic-pituitary-adrenal axis function in ovine pregnancy

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dc.contributor.author Rumball, Christopher en
dc.contributor.author Oliver, Mark en
dc.contributor.author Thorstensen, Eric en
dc.contributor.author Jaquiery, Anne en
dc.contributor.author Husted, SM en
dc.contributor.author Harding, Jane en
dc.date.accessioned 2011-02-03T02:29:42Z en
dc.date.issued 2008-03 en
dc.identifier.citation Endocrinology 149(3):1163-1172 Mar 2008 en
dc.identifier.issn 0013-7227 en
dc.identifier.uri http://hdl.handle.net/2292/6300 en
dc.description.abstract The relationships between reduced size at birth, increased activity of the hypothalamic-pituitary-adrenal (HPA) axis, and increased risk of disease in adulthood are well described in singletons but are much less clear in twins. This may be because the physiological processes underlying reduced size at birth are different in singletons and twins. Periconceptional undernutrition can cause altered activity of the fetal and postnatal HPA axis without altering size at birth. However, the independent effects of periconceptional undernutrition and twinning on activity of the maternal and fetal HPA axes are not well described. We therefore studied maternal and fetal HPA axis function during late gestation in twin and singleton sheep pregnancies, either undernourished around conception or fed ad libitum. We found that twinning led to suppressed baseline HPA axis function and decreased adrenal sensitivity to ACTH stimulation but increased fetal pituitary ACTH response both to direct stimulation by CRH (ACTH area under the curve response: 29.7 +/- 2.2 vs. 17.1 +/- 1.6 ng/min.ml, P < 0.01) and to decreased cortisol negative feedback. In contrast, periconceptional undernutrition resulted in a decreased pituitary response (ACTH area under the curve response: 19.4 +/- 1.6 vs. 26.1 +/- 2.2 ng/min.ml, P = 0.02) but no difference in adrenal response. Thus, the HPA axis function of twin sheep fetuses in late gestation is very different from that of control and undernourished singletons. If the HPA axis is an important mediator between fetal adaptations and adult disease, these data may help explain why the relationship between fetal growth and postnatal physiology and disease risk is inconsistent in twins. en
dc.publisher The Endocrine Society en
dc.relation.ispartofseries Endocrinology en
dc.rights Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. Details obtained from http://www.sherpa.ac.uk/romeo/issn/0013-7227/ en
dc.rights.uri https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm en
dc.title Effects of twinning and periconceptional undernutrition on late-gestation hypothalamic-pituitary-adrenal axis function in ovine pregnancy en
dc.type Journal Article en
dc.identifier.doi 10.1210/en.2007-1306 en
pubs.begin-page 1163 en
pubs.volume 149 en
dc.rights.holder Copyright: 2008 The Endocrine Society en
dc.identifier.pmid 18048493 en
pubs.end-page 1172 en
dc.rights.accessrights http://purl.org/eprint/accessRights/RestrictedAccess en
pubs.subtype Article en
pubs.elements-id 80682 en
pubs.org-id Liggins Institute en
pubs.org-id LiFePATH en
dc.identifier.eissn 1945-7170 en
pubs.record-created-at-source-date 2010-09-01 en
pubs.dimensions-id 18048493 en

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