dc.contributor.author |
Vrijdag, Xavier CE |
|
dc.contributor.author |
van Waart, Hanna |
|
dc.contributor.author |
Mitchell, Simon J |
|
dc.contributor.author |
Sleigh, Jamie W |
|
dc.coverage.spatial |
United States |
|
dc.date.accessioned |
2023-03-06T02:40:17Z |
|
dc.date.available |
2023-03-06T02:40:17Z |
|
dc.date.issued |
2021-02 |
|
dc.identifier.citation |
(2021). Anesthesiology, 134(2), 202-218. |
|
dc.identifier.issn |
0003-3022 |
|
dc.identifier.uri |
https://hdl.handle.net/2292/63121 |
|
dc.description.abstract |
<h4>Background</h4>Nitrous oxide produces non-γ-aminobutyric acid sedation and psychometric impairment and can be used as scientific model for understanding mechanisms of progressive cognitive disturbances. Temporal complexity of the electroencephalogram may be a sensitive indicator of these effects. This study measured psychometric performance and the temporal complexity of the electroencephalogram in participants breathing low-dose nitrous oxide.<h4>Methods</h4>In random order, 20, 30, and 40% end-tidal nitrous oxide was administered to 12 participants while recording 32-channel electroencephalogram and psychometric function. A novel metric quantifying the spatial distribution of temporal electroencephalogram complexity, comprised of (1) absolute cross-correlation calculated between consecutive 0.25-s time samples; 2) binarizing these cross-correlation matrices using the median of all channels as threshold; (3) using quantitative recurrence analysis, the complexity in temporal changes calculated by the Shannon entropy of the probability distribution of the diagonal line lengths; and (4) overall spatial extent and intensity of brain complexity, was quantified by calculating median temporal complexity of channels whose complexities were above 1 at baseline. This region approximately overlay the brain's default mode network, so this summary statistic was termed "default-mode-network complexity."<h4>Results</h4>Nitrous oxide concentration correlated with psychometric impairment (r = 0.50, P < 0.001). Baseline regional electroencephalogram complexity at midline was greater than in lateral temporal channels (1.33 ± 0.14 bits vs. 0.81 ± 0.12 bits, P < 0.001). A dose of 40% N2O decreased midline (mean difference [95% CI], 0.20 bits [0.09 to 0.31], P = 0.002) and prefrontal electroencephalogram complexity (mean difference [95% CI], 0.17 bits [0.08 to 0.27], P = 0.002). The lateral temporal region did not change significantly (mean difference [95% CI], 0.14 bits [-0.03 to 0.30], P = 0.100). Default-mode-network complexity correlated with N2O concentration (r = -0.55, P < 0.001). A default-mode-network complexity mixed-effects model correlated with psychometric impairment (r2 = 0.67; receiver operating characteristic area [95% CI], 0.72 [0.59 to 0.85], P < 0.001).<h4>Conclusions</h4>Temporal complexity decreased most markedly in medial cortical regions during low-dose nitrous oxide exposures, and this change tracked psychometric impairment.<h4>Editor’s perspective</h4> |
|
dc.format.medium |
Print |
|
dc.language |
eng |
|
dc.publisher |
Wolters Kluwer |
|
dc.relation.ispartofseries |
Anesthesiology |
|
dc.rights |
Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. |
|
dc.rights |
This is a pre-copyedited, author-produced version of an article accepted for publication in Anesthesiology. The published version of record Anesthesiology 134(2):202-218 Feb 2021
is available online at: http://doi.org/10.1097/aln.0000000000003628 |
|
dc.rights.uri |
https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm |
|
dc.rights.uri |
https://www.wolterskluwer.com/en/solutions/lippincott-journals/lippincott-open-access/partner/institutions |
|
dc.subject |
Temporal Lobe |
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dc.subject |
Humans |
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dc.subject |
Nitrous Oxide |
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dc.subject |
Anesthetics, Inhalation |
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dc.subject |
Electroencephalography |
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dc.subject |
Cross-Over Studies |
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dc.subject |
Single-Blind Method |
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dc.subject |
Psychometrics |
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dc.subject |
Dose-Response Relationship, Drug |
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dc.subject |
Adult |
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dc.subject |
Middle Aged |
|
dc.subject |
Female |
|
dc.subject |
Male |
|
dc.subject |
Young Adult |
|
dc.subject |
Cognitive Dysfunction |
|
dc.subject |
Brain Disorders |
|
dc.subject |
Science & Technology |
|
dc.subject |
Life Sciences & Biomedicine |
|
dc.subject |
Anesthesiology |
|
dc.subject |
1103 Clinical Sciences |
|
dc.title |
An Electroencephalogram Metric of Temporal Complexity Tracks Psychometric Impairment Caused by Low-dose Nitrous Oxide. |
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dc.type |
Journal Article |
|
dc.identifier.doi |
10.1097/aln.0000000000003628 |
|
pubs.issue |
2 |
|
pubs.begin-page |
202 |
|
pubs.volume |
134 |
|
dc.date.updated |
2023-02-20T03:59:06Z |
|
dc.rights.holder |
Copyright: American Society of Anesthesiologists |
en |
dc.identifier.pmid |
33433619 (pubmed) |
|
pubs.author-url |
https://www.ncbi.nlm.nih.gov/pubmed/33433619 |
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pubs.end-page |
218 |
|
pubs.publication-status |
Published |
|
dc.rights.accessrights |
http://purl.org/eprint/accessRights/OpenAccess |
en |
pubs.subtype |
Research Support, Non-U.S. Gov't |
|
pubs.subtype |
Journal Article |
|
pubs.elements-id |
834001 |
|
pubs.org-id |
Medical and Health Sciences |
|
pubs.org-id |
School of Medicine |
|
pubs.org-id |
Anaesthesiology |
|
dc.identifier.eissn |
1528-1175 |
|
dc.identifier.pii |
114651 |
|
pubs.record-created-at-source-date |
2023-02-20 |
|
pubs.online-publication-date |
2020-12-02 |
|