dc.contributor.author |
Chan, Amy Hai Yan |
|
dc.contributor.author |
Vervloet, Marcia |
|
dc.contributor.author |
Lycett, Helen |
|
dc.contributor.author |
Brabers, Anne |
|
dc.contributor.author |
van Dijk, Liset |
|
dc.contributor.author |
Horne, Rob |
|
dc.coverage.spatial |
England |
|
dc.date.accessioned |
2023-03-07T01:35:45Z |
|
dc.date.available |
2023-03-07T01:35:45Z |
|
dc.date.issued |
2021-11 |
|
dc.identifier.citation |
(2021). British Journal of Clinical Pharmacology, 87(11), 4197-4211. |
|
dc.identifier.issn |
0306-5251 |
|
dc.identifier.uri |
https://hdl.handle.net/2292/63150 |
|
dc.description.abstract |
<h4>Aim</h4>This study reports the development and validation of a new self-report measure, the Medication Practical barriers to Adherence Questionnaire (MPRAQ), which assesses practical barriers to medication adherence.<h4>Methods</h4>The MPRAQ comprises 15 statements describing practical barriers. Responses are scored on a 5-point Likert scale; higher scores indicate more practical barriers. Initial face validity was evaluated by cognitive testing with patients from a diabetes support group. Following refinement, internal reliability and construct validity were assessed in two samples: patients recruited via Amazon mTurk and the Nivel Dutch Healthcare Consumer Panel (COPA). Respondents completed the Beliefs about Medicines Questionnaire (BMQ-General and BMQ-Specific), and the Medication Adherence Report Scale (MARS-5). The mTurk sample also completed the Perceived Sensitivity to Medicines questionnaire (PSM) and repeated the MPRAQ 2 weeks later to assess test-retest reliability.<h4>Results</h4>Face validity was evaluated in 15 patients (46% female; mean (SD) age 64 (12) years). A total of 184 mTurk participants completed the questionnaire (in English) and 334 in COPA (in Dutch). Internal reliability was acceptable (mTurk α = 0.89; COPA α = 0.94). Construct validity was confirmed, with significant correlation between the MPRAQ and BMQ-Specific Concerns (mTurk r = 0.546, P < .0001; COPA r = 0.370, P < .0001), BMQ-General Harm (mTurk r = 0.504, P < 0.0001; COPA r = 0.219, P < .0001), BMQ-General Overuse (mTurk r = 0.324, P < .0001; COPA r = 0.109, P = .047) and PSM (mTurk only r = 0.463, P < .0001), and a negative correlation with MARS-5 (mTurk r = -0.450, P < .0001; COPA r = -0.260, P < .0001). MPRAQ did not correlate with BMQ-Specific Necessity or BMQ-General Benefit. Correlation between MPRAQ baseline and 2-week follow-up scores confirmed test-retest reliability (r = 0.745, P < .0001; n = 52).<h4>Conclusion</h4>MPRAQ is a reliable and valid self-report measure of practical adherence barriers. |
|
dc.format.medium |
Print-Electronic |
|
dc.language |
eng |
|
dc.publisher |
Wiley |
|
dc.relation.ispartofseries |
British journal of clinical pharmacology |
|
dc.rights |
Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. |
|
dc.rights.uri |
https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm |
|
dc.subject |
MPRAQ |
|
dc.subject |
adherence |
|
dc.subject |
medication |
|
dc.subject |
practicalities |
|
dc.subject |
questionnaire |
|
dc.subject |
validation |
|
dc.subject |
Cross-Sectional Studies |
|
dc.subject |
Female |
|
dc.subject |
Health Knowledge, Attitudes, Practice |
|
dc.subject |
Humans |
|
dc.subject |
Male |
|
dc.subject |
Medication Adherence |
|
dc.subject |
Middle Aged |
|
dc.subject |
Reproducibility of Results |
|
dc.subject |
Self Report |
|
dc.subject |
Surveys and Questionnaires |
|
dc.subject |
Behavioral and Social Science |
|
dc.subject |
Clinical Research |
|
dc.subject |
Science & Technology |
|
dc.subject |
Life Sciences & Biomedicine |
|
dc.subject |
Pharmacology & Pharmacy |
|
dc.subject |
PRESCRIPTION MEDICATIONS |
|
dc.subject |
DIFFERENT BELIEFS |
|
dc.subject |
MEDICINES |
|
dc.subject |
PERCEPTIONS |
|
dc.subject |
NONADHERENCE |
|
dc.subject |
ASSOCIATION |
|
dc.subject |
1115 Pharmacology and Pharmaceutical Sciences |
|
dc.title |
Development and validation of a self-report measure of practical barriers to medication adherence: The medication practical barriers to adherence questionnaire (MPRAQ). |
|
dc.type |
Journal Article |
|
dc.identifier.doi |
10.1111/bcp.14744 |
|
pubs.issue |
11 |
|
pubs.begin-page |
4197 |
|
pubs.volume |
87 |
|
dc.date.updated |
2023-02-26T13:15:57Z |
|
dc.rights.holder |
Copyright: The authors |
en |
dc.identifier.pmid |
33486802 (pubmed) |
|
pubs.author-url |
https://www.ncbi.nlm.nih.gov/pubmed/33486802 |
|
pubs.end-page |
4211 |
|
pubs.publication-status |
Published |
|
dc.rights.accessrights |
http://purl.org/eprint/accessRights/RetrictedAccess |
en |
pubs.subtype |
Research Support, Non-U.S. Gov't |
|
pubs.subtype |
Journal Article |
|
pubs.elements-id |
837176 |
|
pubs.org-id |
Medical and Health Sciences |
|
pubs.org-id |
Pharmacy |
|
dc.identifier.eissn |
1365-2125 |
|
pubs.record-created-at-source-date |
2023-02-27 |
|
pubs.online-publication-date |
2021-09-10 |
|