dc.contributor.author |
Joh, Daniel |
|
dc.contributor.author |
Morreau, Mathew |
|
dc.contributor.author |
Lee, Angela |
|
dc.contributor.author |
Pendharkar, Sayali |
|
dc.contributor.author |
Stokes, Bruce |
|
dc.contributor.author |
Warren, Roger |
|
dc.contributor.author |
Hickey, Anthony |
|
dc.contributor.author |
Phillips, Anthony J |
|
dc.contributor.author |
Windsor, John A |
|
dc.coverage.spatial |
Australia |
|
dc.date.accessioned |
2023-03-07T01:40:39Z |
|
dc.date.available |
2023-03-07T01:40:39Z |
|
dc.date.issued |
2022-12 |
|
dc.identifier.citation |
(2022). ANZ Journal of Surgery. |
|
dc.identifier.issn |
1445-1433 |
|
dc.identifier.uri |
https://hdl.handle.net/2292/63152 |
|
dc.description.abstract |
<h4>Background</h4>Acute Mesenteric Ischaemic (AMI) is a rare condition with significant morbidity and mortality. Many causes of AMI exist, which usually begin with mucosal injury. Onset is insiduous and there is frequent diagnostic delay. Current treatments can only control established injury and prevent propagation, hence new interventions are needed. The prevention and treatment of AMI by intraluminal delivery of oxygen has yet to be investigated in the clinical setting. This article aims to systemically review experimental studies investigating this novel therapy.<h4>Methods</h4>Following the PRISMA guidelines, searches of PubMed and Ovid MEDLINE databases were performed up to June 2022. Two independent investigators extracted the data.<h4>Results</h4>There were 20 experimental studies, 16 of which used an occlusive ischaemia reperfusion model. Six different formulations were used to deliver intraluminal oxygen, with perflurocarbon being the most common. Studies consistently showed local and systemic benefits. Intraluminal oxygen therapy improved histological severity of mucosal injury in all studies when oxygen was delivered during the ischaemia phase, but could cause harm if given during the reperfusion phase. Improvement was also demonstrated in endpoints assessing intestinal function, biomarkers of intestinal damage, measures of systemic physiological derangement and mortality.<h4>Conclusion</h4>Intraluminal oxygenation appears to be an effective treatment for AMI. There remain significant questions regarding optimal timing and delivery formulation before clinical translation of this treatment strategy. |
|
dc.format.medium |
Print-Electronic |
|
dc.language |
eng |
|
dc.publisher |
Wiley |
|
dc.relation.ispartofseries |
ANZ journal of surgery |
|
dc.rights |
Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. |
|
dc.rights.uri |
https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm |
|
dc.rights.uri |
http://creativecommons.org/licenses/by-nc-nd/4.0/ |
|
dc.subject |
acute and critical illness |
|
dc.subject |
emergency general surgery |
|
dc.subject |
mesenteric ischaemia |
|
dc.subject |
non-occlusive mesenteric ischaemia |
|
dc.subject |
Prevention |
|
dc.subject |
Biotechnology |
|
dc.subject |
3 Good Health and Well Being |
|
dc.subject |
1103 Clinical Sciences |
|
dc.title |
Intraluminal oxygen mitigates acute mesenteric ischaemia: a systematic review of methods and outcomes in animal studies. |
|
dc.type |
Journal Article |
|
dc.identifier.doi |
10.1111/ans.18211 |
|
dc.date.updated |
2023-02-12T03:08:34Z |
|
dc.rights.holder |
Copyright: The authors |
en |
dc.identifier.pmid |
36537566 (pubmed) |
|
pubs.author-url |
https://www.ncbi.nlm.nih.gov/pubmed/36537566 |
|
pubs.publication-status |
Published |
|
dc.rights.accessrights |
http://purl.org/eprint/accessRights/OpenAccess |
en |
pubs.subtype |
Review |
|
pubs.subtype |
Journal Article |
|
pubs.elements-id |
944613 |
|
pubs.org-id |
Medical and Health Sciences |
|
pubs.org-id |
Science |
|
pubs.org-id |
Science Research |
|
pubs.org-id |
School of Medicine |
|
pubs.org-id |
Surgery Department |
|
pubs.org-id |
Maurice Wilkins Centre (2010-2014) |
|
dc.identifier.eissn |
1445-2197 |
|
pubs.record-created-at-source-date |
2023-02-12 |
|
pubs.online-publication-date |
2022-12-20 |
|