Effects of twinning, birth size, and postnatal growth on glucose tolerance and hypothalamic-pituitary-adrenal function in postpubertal sheep

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dc.contributor.author Bloomfield, Francis en
dc.contributor.author Oliver, Mark en
dc.contributor.author Harding, Jane en
dc.date.accessioned 2011-02-03T02:32:23Z en
dc.date.issued 2007-01 en
dc.identifier.citation AM J PHYSIOL-ENDOC M 292(1):E231-E237 Jan 2007 en
dc.identifier.issn 0193-1849 en
dc.identifier.uri http://hdl.handle.net/2292/6327 en
dc.description.abstract Effects of twinning, birth size, and postnatal growth on glucose tolerance and hypothalamic-pituitary- adrenal function in postpubertal sheep. Am J Physiol Endocrinol Metab 292: E231-E237, 2007. First published August 29, 2006; doi:10.1152/ajpendo.00210.2006.-Low birth weight is associated with postnatal physiological changes, including impaired glucose tolerance and increased cortisol secretion, that may predispose to disease in adulthood. Twins are born lighter than singletons, but there are conflicting data regarding the association between birth weight and postnatal physiology in twins. We studied glucose tolerance and ACTH and cortisol responses to a combined corticotropin-releasing hormone and arginine vasopressin (CRH + AVP) challenge in postpubertal female twin (n = 7 twin pairs) and singleton (n = 13) sheep from the same flock. There were no differences in glucose tolerance between twins and singletons and no association with birth weight. Twins had a greater ACTH (P < 0.05), but not cortisol, response to CRH + AVP than singletons. ACTH area under the curve was inversely related to birth weight in both singletons [R-2 = 0.31, P = 0.05; -8,311 (SD 3,736) pg.min.ml(-1).kg(-1)] and twins (R-2 = 0.49); in twins, this was due to the within-twin pair rather than the between-twin pair coefficient in the regression analysis [P = 0.02, -26,856 (9,806) vs. P = 0.1, 8,619 (4,950) pg.min.ml(-1).kg(-1)]. We conclude that the reduced fetal growth in twins has postnatal consequences for hypothalamic-pituitary-adrenal function and that this is determined by factors specific to the fetus (within-twin pair) rather than by shared maternal factors (between-twin pair). Studies investigating the associations between fetal growth and postnatal outcomes in twins benefit from an appropriate singleton control group and from analyses evaluating the contribution from both between- and within-pair coefficients in twins. en
dc.language EN en
dc.publisher AMER PHYSIOLOGICAL SOC en
dc.relation.ispartofseries AM J PHYSIOL-ENDOC M en
dc.rights Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. en
dc.rights.uri https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm en
dc.subject developmental origins of health and disease en
dc.subject twin pregnancy en
dc.subject hypothalamic-pituitary-adrenal axis en
dc.subject FETAL-ORIGINS HYPOTHESIS en
dc.subject CORONARY-HEART-DISEASE en
dc.subject CATCH-UP GROWTH en
dc.subject FACTOR-I LEVELS en
dc.subject BLOOD-PRESSURE en
dc.subject LATE-GESTATION en
dc.subject CHILDHOOD GROWTH en
dc.subject PERICONCEPTIONAL UNDERNUTRITION en
dc.subject MATERNAL UNDERNUTRITION en
dc.subject INSULIN SENSITIVITY en
dc.title Effects of twinning, birth size, and postnatal growth on glucose tolerance and hypothalamic-pituitary-adrenal function in postpubertal sheep en
dc.type Journal Article en
dc.identifier.doi 10.1152/ajpendo.00210.2006 en
pubs.issue 1 en
pubs.begin-page E231 en
pubs.volume 292 en
dc.rights.holder Copyright: 2007 the American Physiological Society en
dc.identifier.pmid 16940472 en
pubs.end-page E237 en
pubs.publication-status Published en
dc.rights.accessrights http://purl.org/eprint/accessRights/RestrictedAccess en
pubs.subtype Article en
pubs.elements-id 73665 en
pubs.org-id Liggins Institute en
pubs.org-id LiFePATH en
pubs.record-created-at-source-date 2010-09-01 en
pubs.dimensions-id 16940472 en


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