dc.contributor.author |
Zhang, Jie |
|
dc.contributor.author |
Green, Colin R |
|
dc.contributor.author |
Mugisho, Odunayo O |
|
dc.coverage.spatial |
United States |
|
dc.date.accessioned |
2023-03-10T03:05:49Z |
|
dc.date.available |
2023-03-10T03:05:49Z |
|
dc.date.issued |
2021-10 |
|
dc.identifier.citation |
(2021). Experimental Cell Research, 407(2), 112823-. |
|
dc.identifier.issn |
0014-4827 |
|
dc.identifier.uri |
https://hdl.handle.net/2292/63294 |
|
dc.description.abstract |
Cell transdifferentiation is the conversion of a cell type to another without requiring passage through a pluripotent cell state, and encompasses epithelial- and endothelial-mesenchymal transition (EMT and EndMT). EMT and EndMT are well defined processes characterized by a loss of epithelial/endothelial phenotype and gain in mesenchymal spindle shaped morphology, which results in increased cell migration and decreased apoptosis and cellular senescence. Such cells often develop invasive properties. Physiologically, these processes may occur during embryonic development and can resurface, for example, to promote wound healing in later life. However, they can also be a pathological process. In the eye, EMT, EndMT and cell transdifferentiation have all been implicated in development, homeostasis, and multiple diseases affecting different parts of the eye. Connexins, constituents of connexin hemichannels and intercellular gap junctions, have been implicated in many of these processes. In this review, we firstly provide an overview of the molecular mechanisms induced by transdifferentiation (including EMT and EndMT) and its involvement in eye diseases. We then review the literature for the role of connexins in transdifferentiation in the eye and eye diseases. The evidence presented in this review supports the need for more studies into the therapeutic potential for connexin modulators in prevention and treatment of transdifferentiation related eye diseases, but does indicate that connexin channel modulation may be an upstream and unifying approach for regulating these otherwise complex processes. |
|
dc.format.medium |
Print-Electronic |
|
dc.language |
eng |
|
dc.publisher |
Elsevier |
|
dc.relation.ispartofseries |
Experimental cell research |
|
dc.rights |
Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. |
|
dc.rights.uri |
https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm |
|
dc.subject |
Animals |
|
dc.subject |
Humans |
|
dc.subject |
Eye Diseases |
|
dc.subject |
Transforming Growth Factor beta |
|
dc.subject |
Connexins |
|
dc.subject |
Signal Transduction |
|
dc.subject |
Cell Transdifferentiation |
|
dc.subject |
Epithelial-Mesenchymal Transition |
|
dc.subject |
Connexin43 |
|
dc.subject |
EMT |
|
dc.subject |
Endothelial-mesenchymal transition |
|
dc.subject |
Gap junctions |
|
dc.subject |
Hemichannels |
|
dc.subject |
TGF-β |
|
dc.subject |
Stem Cell Research |
|
dc.subject |
Eye Disease and Disorders of Vision |
|
dc.subject |
1.1 Normal biological development and functioning |
|
dc.subject |
1 Underpinning research |
|
dc.subject |
Eye |
|
dc.subject |
Science & Technology |
|
dc.subject |
Life Sciences & Biomedicine |
|
dc.subject |
Oncology |
|
dc.subject |
Cell Biology |
|
dc.subject |
TGF-beta |
|
dc.subject |
GAP-JUNCTION |
|
dc.subject |
UP-REGULATION |
|
dc.subject |
HUMAN LIMBAL |
|
dc.subject |
E-CADHERIN |
|
dc.subject |
CORNEAL |
|
dc.subject |
EXPRESSION |
|
dc.subject |
COMMUNICATION |
|
dc.subject |
DIFFERENTIATION |
|
dc.subject |
PROLIFERATION |
|
dc.subject |
0601 Biochemistry and Cell Biology |
|
dc.subject |
1103 Clinical Sciences |
|
dc.title |
Cell transdifferentiation in ocular disease: Potential role for connexin channels. |
|
dc.type |
Journal Article |
|
dc.identifier.doi |
10.1016/j.yexcr.2021.112823 |
|
pubs.issue |
2 |
|
pubs.begin-page |
112823 |
|
pubs.volume |
407 |
|
dc.date.updated |
2023-02-18T08:18:58Z |
|
dc.rights.holder |
Copyright: The authors |
en |
dc.identifier.pmid |
34506760 (pubmed) |
|
pubs.author-url |
https://www.ncbi.nlm.nih.gov/pubmed/34506760 |
|
pubs.publication-status |
Published |
|
dc.rights.accessrights |
http://purl.org/eprint/accessRights/RetrictedAccess |
en |
pubs.subtype |
Research Support, Non-U.S. Gov't |
|
pubs.subtype |
Review |
|
pubs.subtype |
Journal Article |
|
pubs.elements-id |
865894 |
|
pubs.org-id |
Medical and Health Sciences |
|
pubs.org-id |
Science |
|
pubs.org-id |
Science Research |
|
pubs.org-id |
School of Medicine |
|
pubs.org-id |
Ophthalmology Department |
|
pubs.org-id |
Maurice Wilkins Centre (2010-2014) |
|
dc.identifier.eissn |
1090-2422 |
|
dc.identifier.pii |
S0014-4827(21)00377-3 |
|
pubs.number |
112823 |
|
pubs.record-created-at-source-date |
2023-02-18 |
|
pubs.online-publication-date |
2021-09-10 |
|