Opening up the Toolbox: Synthesis and Mechanisms of Phosphoramidates.

Itumoh, Emeka J; Data, Shailja; Leitao, Erin M

dc.contributor.author	Itumoh, Emeka J
dc.contributor.author	Data, Shailja
dc.contributor.author	Leitao, Erin M
dc.coverage.spatial	Switzerland
dc.date.accessioned	2023-03-15T23:23:24Z
dc.date.available	2023-03-15T23:23:24Z
dc.date.issued	2020-08
dc.identifier.citation	(2020). Molecules, 25(16), E3684-.
dc.identifier.issn	1420-3049
dc.identifier.uri	https://hdl.handle.net/2292/63390
dc.description.abstract	This review covers the main synthetic routes to and the corresponding mechanisms of phosphoramidate formation. The synthetic routes can be separated into six categories: salt elimination, oxidative cross-coupling, azide, reduction, hydrophosphinylation, and phosphoramidate-aldehyde-dienophile (PAD). Examples of some important compounds synthesized through these routes are provided. As an important class of organophosphorus compounds, the applications of phosphoramidate compounds, are also briefly introduced.
dc.format.medium	Electronic
dc.language	eng
dc.publisher	MDPI
dc.relation.ispartofseries	Molecules (Basel, Switzerland)
dc.rights	Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher.
dc.rights.uri	https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm
dc.rights.uri	https://creativecommons.org/licenses/by/4.0/
dc.subject	Phosphoric Acids
dc.subject	Amides
dc.subject	Chemistry Techniques, Synthetic
dc.subject	applications
dc.subject	mechanism
dc.subject	phosphoramidate
dc.subject	synthetic routes
dc.subject	Science & Technology
dc.subject	Life Sciences & Biomedicine
dc.subject	Physical Sciences
dc.subject	Biochemistry & Molecular Biology
dc.subject	Chemistry, Multidisciplinary
dc.subject	Chemistry
dc.subject	POLYPHOSPHORAMIDATE GENE CARRIERS
dc.subject	AMMONO PHOSPHORIC-ACIDS
dc.subject	ATHERTON-TODD REACTION
dc.subject	ONE-POT SYNTHESIS
dc.subject	CATALYZED PHOSPHORAMIDATION
dc.subject	BIOLOGICAL EVALUATION
dc.subject	INSECTICIDAL ACTIVITY
dc.subject	UREASE INHIBITORS
dc.subject	FLAME RETARDANTS
dc.subject	H-PHOSPHONATES
dc.subject	0304 Medicinal and Biomolecular Chemistry
dc.subject	0305 Organic Chemistry
dc.subject	0307 Theoretical and Computational Chemistry
dc.title	Opening up the Toolbox: Synthesis and Mechanisms of Phosphoramidates.
dc.type	Journal Article
dc.identifier.doi	10.3390/molecules25163684
pubs.issue	16
pubs.begin-page	E3684
pubs.volume	25
dc.date.updated	2023-02-28T19:24:59Z
dc.rights.holder	Copyright: The authors	en
dc.identifier.pmid	32823507 (pubmed)
pubs.author-url	https://www.ncbi.nlm.nih.gov/pubmed/32823507
pubs.publication-status	Published
dc.rights.accessrights	http://purl.org/eprint/accessRights/OpenAccess	en
pubs.subtype	IM
pubs.subtype	review-article
pubs.subtype	Review
pubs.subtype	Journal Article
pubs.elements-id	824423
dc.identifier.eissn	1420-3049
dc.identifier.pii	molecules25163684
pubs.number	ARTN 3684
pubs.record-created-at-source-date	2023-03-01
pubs.online-publication-date	2020-08-13