dc.contributor.author |
Thakur, Varsha |
|
dc.contributor.author |
Lu, Jun |
|
dc.contributor.author |
Roscilli, Giuseppe |
|
dc.contributor.author |
Aurisicchio, Luigi |
|
dc.contributor.author |
Cappelletti, Manuela |
|
dc.contributor.author |
Pavoni, Emiliano |
|
dc.contributor.author |
White, William Lindsey |
|
dc.contributor.author |
Bedogni, Barbara |
|
dc.coverage.spatial |
United States |
|
dc.date.accessioned |
2023-04-24T00:57:44Z |
|
dc.date.available |
2023-04-24T00:57:44Z |
|
dc.date.issued |
2017-03 |
|
dc.identifier.citation |
(2017). Oncotarget, 8(11), 17887-17896. |
|
dc.identifier.issn |
1949-2553 |
|
dc.identifier.uri |
https://hdl.handle.net/2292/63845 |
|
dc.description.abstract |
Melanoma remains one of the most aggressive and therapy-resistant cancers. Finding new treatments to improve patient outcomes is an ongoing effort. We previously demonstrated that melanoma relies on the activation of ERBB signaling, specifically of the ERBB3/ERBB2 cascade. Here we show that melanoma tumor growth is inhibited by 60% over controls when treated with lapatinib, a clinically approved inhibitor of ERBB2/EGFR. Importantly, tumor growth is further inhibited to 85% when the natural compound fucoidan from New Zealand U. pinnatifida is integrated into the treatment regimen. Fucoidan not only enhances tumor growth inhibition, it counteracts the morbidity associated with prolonged lapatinib treatment. Fucoidan doubles the cell killing capacity of lapatinib. These effects are associated with a further decrease in AKT and NFκB signaling, two key pathways involved in melanoma cell survival. Importantly, the enhancing cell killing effects of fucoidan can be recapitulated by inhibiting ERBB3 by either a specific shRNA or a novel, selective ERBB3 neutralizing antibody, reiterating the key roles played by this receptor in melanoma. We therefore propose the use of lapatinib or specific ERBB inhibitors, in combination with fucoidan as a new treatment of melanoma that potentiates the effects of the inhibitors while protecting from their potential side effects. |
|
dc.format.medium |
Print |
|
dc.language |
eng |
|
dc.publisher |
Impact Journals, LLC |
|
dc.relation.ispartofseries |
Oncotarget |
|
dc.rights |
Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. |
|
dc.rights.uri |
https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm |
|
dc.rights.uri |
https://creativecommons.org/licenses/by/3.0/ |
|
dc.subject |
Cell Line, Tumor |
|
dc.subject |
Animals |
|
dc.subject |
Humans |
|
dc.subject |
Mice |
|
dc.subject |
Mice, SCID |
|
dc.subject |
Undaria |
|
dc.subject |
Melanoma |
|
dc.subject |
Quinazolines |
|
dc.subject |
Receptor, erbB-2 |
|
dc.subject |
Receptor, erbB-3 |
|
dc.subject |
Polysaccharides |
|
dc.subject |
RNA, Small Interfering |
|
dc.subject |
Antineoplastic Agents |
|
dc.subject |
Antineoplastic Combined Chemotherapy Protocols |
|
dc.subject |
Cell Proliferation |
|
dc.subject |
Cell Survival |
|
dc.subject |
RNA Interference |
|
dc.subject |
Drug Synergism |
|
dc.subject |
New Zealand |
|
dc.subject |
Male |
|
dc.subject |
Proto-Oncogene Proteins c-akt |
|
dc.subject |
Transcription Factor RelA |
|
dc.subject |
ErbB Receptors |
|
dc.subject |
Lapatinib |
|
dc.subject |
ERBB3 |
|
dc.subject |
fucoidan |
|
dc.subject |
natural compounds |
|
dc.subject |
Cancer |
|
dc.subject |
5.1 Pharmaceuticals |
|
dc.subject |
5 Development of treatments and therapeutic interventions |
|
dc.subject |
1112 Oncology and Carcinogenesis |
|
dc.title |
The natural compound fucoidan from New Zealand Undaria pinnatifida synergizes with the ERBB inhibitor lapatinib enhancing melanoma growth inhibition. |
|
dc.type |
Journal Article |
|
dc.identifier.doi |
10.18632/oncotarget.14437 |
|
pubs.issue |
11 |
|
pubs.begin-page |
17887 |
|
pubs.volume |
8 |
|
dc.date.updated |
2023-03-26T20:01:09Z |
|
dc.rights.holder |
Copyright: The authors |
en |
dc.identifier.pmid |
28060735 (pubmed) |
|
pubs.author-url |
https://www.ncbi.nlm.nih.gov/pubmed/28060735 |
|
pubs.end-page |
17896 |
|
pubs.publication-status |
Published |
|
dc.rights.accessrights |
http://purl.org/eprint/accessRights/OpenAccess |
en |
pubs.subtype |
research-article |
|
pubs.subtype |
Journal Article |
|
pubs.elements-id |
945860 |
|
pubs.org-id |
Bioengineering Institute |
|
dc.identifier.eissn |
1949-2553 |
|
dc.identifier.pii |
14437 |
|
pubs.record-created-at-source-date |
2023-03-27 |
|
pubs.online-publication-date |
2017-01-02 |
|