dc.contributor.author |
Maran, Jack J |
|
dc.contributor.author |
Adesina, Moradeke M |
|
dc.contributor.author |
Green, Colin R |
|
dc.contributor.author |
Kwakowsky, Andrea |
|
dc.contributor.author |
Mugisho, Odunayo O |
|
dc.coverage.spatial |
England |
|
dc.date.accessioned |
2023-06-27T23:01:34Z |
|
dc.date.available |
2023-06-27T23:01:34Z |
|
dc.date.issued |
2023-05 |
|
dc.identifier.citation |
(2023). Ageing Research Reviews, 88, 101954-. |
|
dc.identifier.issn |
1568-1637 |
|
dc.identifier.uri |
https://hdl.handle.net/2292/64409 |
|
dc.description.abstract |
With increasing age, structural changes occur in the eye and brain. Neuronal death, inflammation, vascular disruption, and microglial activation are among many of the pathological changes that can occur during ageing. Furthermore, ageing individuals are at increased risk of developing neurodegenerative diseases in these organs, including Alzheimer's disease (AD), Parkinson's disease (PD), glaucoma and age-related macular degeneration (AMD). Although these diseases pose a significant global public health burden, current treatment options focus on slowing disease progression and symptomatic control rather than targeting underlying causes. Interestingly, recent investigations have proposed an analogous aetiology between age-related diseases in the eye and brain, where a process of chronic low-grade inflammation is implicated. Studies have suggested that patients with AD or PD are also associated with an increased risk of AMD, glaucoma, and cataracts. Moreover, pathognomonic amyloid-β and α-synuclein aggregates, which accumulate in AD and PD, respectively, can be found in ocular parenchyma. In terms of a common molecular pathway that underpins these diseases, the nucleotide-binding domain, leucine-rich-containing family, and pyrin domain-containing-3 (NLRP3) inflammasome is thought to play a vital role in the manifestation of all these diseases. This review summarises the current evidence regarding cellular and molecular changes in the brain and eye with age, similarities between ocular and cerebral age-related diseases, and the role of the NLRP3 inflammasome as a critical mediator of disease propagation in the eye and the brain during ageing. |
|
dc.format.medium |
Print-Electronic |
|
dc.language |
eng |
|
dc.publisher |
Elsevier BV |
|
dc.relation.ispartofseries |
Ageing research reviews |
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dc.rights |
Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. |
|
dc.rights.uri |
https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm |
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dc.subject |
Inflammasome |
|
dc.subject |
age-related macular degeneration |
|
dc.subject |
cataract |
|
dc.subject |
dementia |
|
dc.subject |
glaucoma |
|
dc.subject |
inflammaging |
|
dc.subject |
Acquired Cognitive Impairment |
|
dc.subject |
Eye Disease and Disorders of Vision |
|
dc.subject |
Parkinson's Disease |
|
dc.subject |
Brain Disorders |
|
dc.subject |
Aging |
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dc.subject |
Macular Degeneration |
|
dc.subject |
Neurodegenerative |
|
dc.subject |
Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD) |
|
dc.subject |
Alzheimer's Disease |
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dc.subject |
Neurosciences |
|
dc.subject |
2.1 Biological and endogenous factors |
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dc.subject |
2 Aetiology |
|
dc.subject |
Eye |
|
dc.subject |
Neurological |
|
dc.subject |
0601 Biochemistry and Cell Biology |
|
dc.subject |
1103 Clinical Sciences |
|
dc.subject |
1109 Neurosciences |
|
dc.title |
The central role of the NLRP3 inflammasome pathway in the pathogenesis of age-related diseases in the eye and the brain. |
|
dc.type |
Journal Article |
|
dc.identifier.doi |
10.1016/j.arr.2023.101954 |
|
pubs.begin-page |
101954 |
|
pubs.volume |
88 |
|
dc.date.updated |
2023-05-20T10:11:08Z |
|
dc.rights.holder |
Copyright: The authors |
en |
dc.identifier.pmid |
37187367 (pubmed) |
|
pubs.author-url |
https://www.ncbi.nlm.nih.gov/pubmed/37187367 |
|
pubs.publication-status |
Published |
|
dc.rights.accessrights |
http://purl.org/eprint/accessRights/RetrictedAccess |
en |
pubs.subtype |
Review |
|
pubs.subtype |
Journal Article |
|
pubs.elements-id |
961578 |
|
pubs.org-id |
Medical and Health Sciences |
|
pubs.org-id |
Science |
|
pubs.org-id |
Science Research |
|
pubs.org-id |
School of Medicine |
|
pubs.org-id |
Ophthalmology Department |
|
pubs.org-id |
Maurice Wilkins Centre (2010-2014) |
|
dc.identifier.eissn |
1872-9649 |
|
dc.identifier.pii |
S1568-1637(23)00113-7 |
|
pubs.number |
101954 |
|
pubs.record-created-at-source-date |
2023-05-20 |
|
pubs.online-publication-date |
2023-05-13 |
|