The Synthesis and Bioactivity of the Marine Macrolide Callyspongiolide.

Ko, Kwang-Yoon; Wilson, Zoe E; Brimble, Margaret A

dc.contributor.author	Ko, Kwang-Yoon
dc.contributor.author	Wilson, Zoe E
dc.contributor.author	Brimble, Margaret A
dc.coverage.spatial	Germany
dc.date.accessioned	2023-07-10T04:24:39Z
dc.date.available	2023-07-10T04:24:39Z
dc.date.issued	2021-02
dc.identifier.citation	(2021). Chemistry: A European Journal, 27(8), 2589-2611.
dc.identifier.issn	0947-6539
dc.identifier.uri	https://hdl.handle.net/2292/64610
dc.description.abstract	Callyspongiolide, a macrolide natural product with a conjugated diene-ynic side chain, has garnered significant attention from the synthetic community since its isolation from a sea sponge in 2013. Herein, the approaches that have been applied to this bioactive natural product to date are reviewed. These synthetic endeavors have established the absolute stereochemistry of this molecule and allowed further investigation into its promising caspase-independent bioactivity, while also contributing to the wider field of macrolide synthesis.
dc.format.medium	Print-Electronic
dc.language	eng
dc.publisher	Wiley
dc.relation.ispartofseries	Chemistry (Weinheim an der Bergstrasse, Germany)
dc.rights	Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher.
dc.rights.uri	https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm
dc.subject	Macrolides
dc.subject	Caspases
dc.subject	Biological Products
dc.subject	Molecular Structure
dc.subject	Stereoisomerism
dc.subject	callyspongiolide
dc.subject	caspase-independent cytotoxicity
dc.subject	marine natural products
dc.subject	total synthesis
dc.subject	Vaccine Related
dc.subject	Science & Technology
dc.subject	Physical Sciences
dc.subject	Chemistry, Multidisciplinary
dc.subject	Chemistry
dc.subject	ENANTIOSELECTIVE TOTAL-SYNTHESIS
dc.subject	RED-SEA SPONGE
dc.subject	STRUCTURAL ASSIGNMENT
dc.subject	CYTOTOXIC MACROLIDE
dc.subject	NATURAL-PRODUCTS
dc.subject	FORMAL SYNTHESIS
dc.subject	FRAGMENT
dc.subject	HOMOCROTYLBORATION
dc.subject	STEREOCHEMISTRY
dc.subject	CALLYSTATIN
dc.subject	03 Chemical Sciences
dc.title	The Synthesis and Bioactivity of the Marine Macrolide Callyspongiolide.
dc.type	Journal Article
dc.identifier.doi	10.1002/chem.202003898
pubs.issue	8
pubs.begin-page	2589
pubs.volume	27
dc.date.updated	2023-06-29T00:30:58Z
dc.rights.holder	Copyright: The authors	en
dc.identifier.pmid	32989817 (pubmed)
pubs.author-url	https://www.ncbi.nlm.nih.gov/pubmed/32989817
pubs.end-page	2611
pubs.publication-status	Published
dc.rights.accessrights	http://purl.org/eprint/accessRights/RetrictedAccess	en
pubs.subtype	Review
pubs.subtype	Journal Article
pubs.elements-id	826850
pubs.org-id	Science
pubs.org-id	Chemistry
pubs.org-id	Science Research
pubs.org-id	Maurice Wilkins Centre (2010-2014)
dc.identifier.eissn	1521-3765
pubs.record-created-at-source-date	2023-06-29
pubs.online-publication-date	2020-12-14