dc.contributor.author |
Zhu, Ruixin |
|
dc.contributor.author |
Craciun, Ionut |
|
dc.contributor.author |
Bernhards-Werge, Jan |
|
dc.contributor.author |
Jalo, Elli |
|
dc.contributor.author |
Poppitt, Sally D |
|
dc.contributor.author |
Silvestre, Marta P |
|
dc.contributor.author |
Huttunen-Lenz, Maija |
|
dc.contributor.author |
McNarry, Melitta A |
|
dc.contributor.author |
Stratton, Gareth |
|
dc.contributor.author |
Handjiev, Svetoslav |
|
dc.contributor.author |
Handjieva-Darlenska, Teodora |
|
dc.contributor.author |
Navas-Carretero, Santiago |
|
dc.contributor.author |
Sundvall, Jouko |
|
dc.contributor.author |
Adam, Tanja C |
|
dc.contributor.author |
Drummen, Mathijs |
|
dc.contributor.author |
Simpson, Elizabeth J |
|
dc.contributor.author |
Macdonald, Ian A |
|
dc.contributor.author |
Brand-Miller, Jennie |
|
dc.contributor.author |
Muirhead, Roslyn |
|
dc.contributor.author |
Lam, Tony |
|
dc.contributor.author |
Vestentoft, Pia S |
|
dc.contributor.author |
Færch, Kristine |
|
dc.contributor.author |
Martinez, J Alfredo |
|
dc.contributor.author |
Fogelholm, Mikael |
|
dc.contributor.author |
Raben, Anne |
|
dc.coverage.spatial |
Germany |
|
dc.date.accessioned |
2023-07-17T04:28:16Z |
|
dc.date.available |
2023-07-17T04:28:16Z |
|
dc.date.issued |
2022-08 |
|
dc.identifier.citation |
(2022). Diabetologia, 65(8), 1262-1277. |
|
dc.identifier.issn |
0012-186X |
|
dc.identifier.uri |
https://hdl.handle.net/2292/64810 |
|
dc.description.abstract |
<h4>Aims/hypothesis</h4>Lifestyle interventions are the first-line treatment option for body weight and cardiometabolic health management. However, whether age groups or women and men respond differently to lifestyle interventions is under debate. We aimed to examine age- and sex-specific effects of a low-energy diet (LED) followed by a long-term lifestyle intervention on body weight, body composition and cardiometabolic health markers in adults with prediabetes (i.e. impaired fasting glucose and/or impaired glucose tolerance).<h4>Methods</h4>This observational study used longitudinal data from 2223 overweight participants with prediabetes in the multicentre diabetes prevention study PREVIEW. The participants underwent a LED-induced rapid weight loss (WL) period followed by a 3 year lifestyle-based weight maintenance (WM) intervention. Changes in outcomes of interest in prespecified age (younger: 25-45 years; middle-aged: 46-54 years; older: 55-70 years) or sex (women and men) groups were compared.<h4>Results</h4>In total, 783 younger, 319 middle-aged and 1121 older adults and 1503 women and 720 men were included in the analysis. In the available case and complete case analyses, multivariable-adjusted linear mixed models showed that younger and older adults had similar weight loss after the LED, whereas older adults had greater sustained weight loss after the WM intervention (adjusted difference for older vs younger adults -1.25% [95% CI -1.92, -0.58], p<0.001). After the WM intervention, older adults lost more fat-free mass and bone mass and had smaller improvements in 2 h plasma glucose (adjusted difference for older vs younger adults 0.65 mmol/l [95% CI 0.50, 0.80], p<0.001) and systolic blood pressure (adjusted difference for older vs younger adults 2.57 mmHg [95% CI 1.37, 3.77], p<0.001) than younger adults. Older adults had smaller decreases in fasting and 2 h glucose, HbA<sub>1c</sub> and systolic blood pressure after the WM intervention than middle-aged adults. In the complete case analysis, the above-mentioned differences between middle-aged and older adults disappeared, but the direction of the effect size did not change. After the WL period, compared with men, women had less weight loss (adjusted difference for women vs men 1.78% [95% CI 1.12, 2.43], p<0.001) with greater fat-free mass and bone mass loss and smaller improvements in HbA<sub>1c</sub>, LDL-cholesterol and diastolic blood pressure. After the WM intervention, women had greater fat-free mass and bone mass loss and smaller improvements in HbA<sub>1c</sub> and LDL-cholesterol, while they had greater improvements in fasting glucose, triacylglycerol (adjusted difference for women vs men -0.08 mmol/l [-0.11, -0.04], p<0.001) and HDL-cholesterol.<h4>Conclusions/interpretation</h4>Older adults benefited less from a lifestyle intervention in relation to body composition and cardiometabolic health markers than younger adults, despite greater sustained weight loss. Women benefited less from a LED followed by a lifestyle intervention in relation to body weight and body composition than men. Future interventions targeting older adults or women should take prevention of fat-free mass and bone mass loss into consideration.<h4>Clinical trial registration number</h4>ClinicalTrials.gov NCT01777893. |
|
dc.format.medium |
Print-Electronic |
|
dc.language |
eng |
|
dc.publisher |
Springer Nature |
|
dc.relation.ispartofseries |
Diabetologia |
|
dc.rights |
Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. |
|
dc.rights.uri |
https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm |
|
dc.rights.uri |
http://creativecommons.org/licenses/by/4.0/ |
|
dc.subject |
Humans |
|
dc.subject |
Cardiovascular Diseases |
|
dc.subject |
Prediabetic State |
|
dc.subject |
Weight Loss |
|
dc.subject |
Glucose |
|
dc.subject |
Blood Glucose |
|
dc.subject |
Life Style |
|
dc.subject |
Adult |
|
dc.subject |
Aged |
|
dc.subject |
Middle Aged |
|
dc.subject |
Female |
|
dc.subject |
Male |
|
dc.subject |
Cholesterol, LDL |
|
dc.subject |
Cholesterol, HDL |
|
dc.subject |
Biomarkers |
|
dc.subject |
Cardiovascular disease |
|
dc.subject |
Men |
|
dc.subject |
Middle-aged people |
|
dc.subject |
Obesity |
|
dc.subject |
Older people |
|
dc.subject |
Weight loss maintenance |
|
dc.subject |
Women |
|
dc.subject |
Young people |
|
dc.subject |
Cardiovascular |
|
dc.subject |
Aging |
|
dc.subject |
Diabetes |
|
dc.subject |
Clinical Research |
|
dc.subject |
Prevention |
|
dc.subject |
Clinical Trials and Supportive Activities |
|
dc.subject |
Nutrition |
|
dc.subject |
3.1 Primary prevention interventions to modify behaviours or promote wellbeing |
|
dc.subject |
3 Prevention of disease and conditions, and promotion of well-being |
|
dc.subject |
Metabolic and endocrine |
|
dc.subject |
3 Good Health and Well Being |
|
dc.subject |
Science & Technology |
|
dc.subject |
Life Sciences & Biomedicine |
|
dc.subject |
Endocrinology & Metabolism |
|
dc.subject |
FAT-FREE MASS |
|
dc.subject |
LOSS MAINTENANCE |
|
dc.subject |
RISK-FACTORS |
|
dc.subject |
OVERWEIGHT |
|
dc.subject |
OLDER |
|
dc.subject |
ASSOCIATION |
|
dc.subject |
MANAGEMENT |
|
dc.subject |
INDIVIDUALS |
|
dc.subject |
GUIDELINES |
|
dc.subject |
1103 Clinical Sciences |
|
dc.subject |
1114 Paediatrics and Reproductive Medicine |
|
dc.subject |
1117 Public Health and Health Services |
|
dc.title |
Age- and sex-specific effects of a long-term lifestyle intervention on body weight and cardiometabolic health markers in adults with prediabetes: results from the diabetes prevention study PREVIEW. |
|
dc.type |
Journal Article |
|
dc.identifier.doi |
10.1007/s00125-022-05716-3 |
|
pubs.issue |
8 |
|
pubs.begin-page |
1262 |
|
pubs.volume |
65 |
|
dc.date.updated |
2023-06-21T15:30:40Z |
|
dc.rights.holder |
Copyright: The authors |
en |
dc.identifier.pmid |
35610522 (pubmed) |
|
pubs.author-url |
https://www.ncbi.nlm.nih.gov/pubmed/35610522 |
|
pubs.end-page |
1277 |
|
pubs.publication-status |
Published |
|
dc.rights.accessrights |
http://purl.org/eprint/accessRights/OpenAccess |
en |
pubs.subtype |
Research Support, Non-U.S. Gov't |
|
pubs.subtype |
research-article |
|
pubs.subtype |
Journal Article |
|
pubs.subtype |
Observational Study |
|
pubs.elements-id |
903111 |
|
pubs.org-id |
Science |
|
pubs.org-id |
Biological Sciences |
|
dc.identifier.eissn |
1432-0428 |
|
dc.identifier.pii |
10.1007/s00125-022-05716-3 |
|
pubs.record-created-at-source-date |
2023-06-22 |
|
pubs.online-publication-date |
2022-05-25 |
|