dc.contributor.author |
Smyth, Leon CD |
|
dc.contributor.author |
Highet, Blake |
|
dc.contributor.author |
Jansson, Deidre |
|
dc.contributor.author |
Wu, Jane |
|
dc.contributor.author |
Rustenhoven, Justin |
|
dc.contributor.author |
Aalderink, Miranda |
|
dc.contributor.author |
Tan, Adelie |
|
dc.contributor.author |
Li, Susan |
|
dc.contributor.author |
Johnson, Rebecca |
|
dc.contributor.author |
Coppieters, Natacha |
|
dc.contributor.author |
Handley, Renee |
|
dc.contributor.author |
Narayan, Pritika |
|
dc.contributor.author |
Singh-Bains, Malvindar K |
|
dc.contributor.author |
Schweder, Patrick |
|
dc.contributor.author |
Turner, Clinton |
|
dc.contributor.author |
Mee, Edward W |
|
dc.contributor.author |
Heppner, Peter |
|
dc.contributor.author |
Correia, Jason |
|
dc.contributor.author |
Park, Thomas I-H |
|
dc.contributor.author |
Curtis, Maurice A |
|
dc.contributor.author |
Faull, Richard LM |
|
dc.contributor.author |
Dragunow, Mike |
|
dc.coverage.spatial |
England |
|
dc.date.accessioned |
2023-07-17T04:32:12Z |
|
dc.date.available |
2023-07-17T04:32:12Z |
|
dc.date.issued |
2022-03 |
|
dc.identifier.citation |
(2022). Communications Biology, 5(1), 235-. |
|
dc.identifier.issn |
2399-3642 |
|
dc.identifier.uri |
https://hdl.handle.net/2292/64812 |
|
dc.description.abstract |
Platelet-derived growth factor-BB (PDGF-BB):PDGF receptor-β (PDGFRβ) signalling in brain pericytes is critical to the development, maintenance and function of a healthy blood-brain barrier (BBB). Furthermore, BBB impairment and pericyte loss in Alzheimer's disease (AD) is well documented. We found that PDGF-BB:PDGFRβ signalling components were altered in human AD brains, with a marked reduction in vascular PDGFB. We hypothesised that reduced PDGF-BB:PDGFRβ signalling in pericytes may impact on the BBB. We therefore tested the effects of PDGF-BB on primary human brain pericytes in vitro to define pathways related to BBB function. Using pharmacological inhibitors, we dissected distinct aspects of the PDGF-BB response that are controlled by extracellular signal-regulated kinase (ERK) and Akt pathways. PDGF-BB promotes the proliferation of pericytes and protection from apoptosis through ERK signalling. In contrast, PDGF-BB:PDGFRβ signalling through Akt augments pericyte-derived inflammatory secretions. It may therefore be possible to supplement PDGF-BB signalling to stabilise the cerebrovasculature in AD. |
|
dc.format.medium |
Electronic |
|
dc.language |
eng |
|
dc.publisher |
Springer Nature |
|
dc.relation.ispartofseries |
Communications biology |
|
dc.rights |
Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. |
|
dc.rights.uri |
https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm |
|
dc.rights.uri |
http://creativecommons.org/licenses/by/4.0/ |
|
dc.subject |
Pericytes |
|
dc.subject |
Brain |
|
dc.subject |
Humans |
|
dc.subject |
Alzheimer Disease |
|
dc.subject |
Receptor, Platelet-Derived Growth Factor beta |
|
dc.subject |
Becaplermin |
|
dc.subject |
Aging |
|
dc.subject |
Brain Disorders |
|
dc.subject |
Clinical Research |
|
dc.subject |
Neurosciences |
|
dc.subject |
Dementia |
|
dc.subject |
Acquired Cognitive Impairment |
|
dc.subject |
Alzheimer's Disease |
|
dc.subject |
Neurodegenerative |
|
dc.subject |
Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD) |
|
dc.subject |
2 Aetiology |
|
dc.subject |
1 Underpinning research |
|
dc.subject |
2.1 Biological and endogenous factors |
|
dc.subject |
1.1 Normal biological development and functioning |
|
dc.subject |
Neurological |
|
dc.subject |
Science & Technology |
|
dc.subject |
Life Sciences & Biomedicine |
|
dc.subject |
Biology |
|
dc.subject |
Multidisciplinary Sciences |
|
dc.subject |
Life Sciences & Biomedicine - Other Topics |
|
dc.subject |
Science & Technology - Other Topics |
|
dc.subject |
TRANSCRIPTION FACTOR |
|
dc.subject |
RECEPTOR |
|
dc.subject |
CELLS |
|
dc.subject |
ACTIVATION |
|
dc.subject |
CONTRIBUTE |
|
dc.title |
Characterisation of PDGF-BB:PDGFRβ signalling pathways in human brain pericytes: evidence of disruption in Alzheimer's disease. |
|
dc.type |
Journal Article |
|
dc.identifier.doi |
10.1038/s42003-022-03180-8 |
|
pubs.issue |
1 |
|
pubs.begin-page |
235 |
|
pubs.volume |
5 |
|
dc.date.updated |
2023-05-31T23:46:54Z |
|
dc.rights.holder |
Copyright: The authors |
en |
dc.identifier.pmid |
35301433 (pubmed) |
|
pubs.author-url |
https://www.ncbi.nlm.nih.gov/pubmed/35301433 |
|
pubs.publication-status |
Published |
|
dc.rights.accessrights |
http://purl.org/eprint/accessRights/OpenAccess |
en |
pubs.subtype |
Research Support, Non-U.S. Gov't |
|
pubs.subtype |
research-article |
|
pubs.subtype |
Journal Article |
|
pubs.elements-id |
890586 |
|
pubs.org-id |
Medical and Health Sciences |
|
pubs.org-id |
Science |
|
pubs.org-id |
Biological Sciences |
|
pubs.org-id |
Statistics |
|
pubs.org-id |
Medical Sciences |
|
pubs.org-id |
Anatomy and Medical Imaging |
|
pubs.org-id |
Pharmacology |
|
dc.identifier.eissn |
2399-3642 |
|
dc.identifier.pii |
10.1038/s42003-022-03180-8 |
|
pubs.number |
235 |
|
pubs.record-created-at-source-date |
2023-06-01 |
|
pubs.online-publication-date |
2022-03-17 |
|