Trefoil factor 1 and chemoresistance in breast cancer

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dc.contributor.advisor Lobie, Peter E en
dc.contributor.advisor Liu, DongXu en Hong, Cho Rong en 2011-02-28T09:59:04Z en 2011-02-28T09:59:04Z en 2011 en
dc.identifier.uri en
dc.description Full Text is available to authenticated members of The University of Auckland only. en
dc.description.abstract Chemo-resistance is the major cause of clinical failure in breast cancer and more complete understanding of factors contributing to drug resistance would improve treatment outcome. Trefoil factor 1 (TFF1) is a secreted protein which is expressed mainly in the gastro-intestinal tract. TFF1 is one of the major factors involved in restitution and maintenance of the gut barrier. During restitution, TFF1 modulates cell proliferation, cell migration, and angiogenesis while inhibiting apoptosis, processes necessary for rapid gut repairing. Elevated levels of TFF1 expression is observed in breast cancer, indicating that selective up-regulation of TFF1 may have a role in oncogenesis. The putative roles of TFF1 in cancer progression include cancer cell proliferation, migration, apoptosis, and angiogenesis. Recently, it was demonstrated that TFF1 modulates the immune response and cell differentiation. Although the oncogenic function of TFF1 in breast cancer has been documented by various studies, the relationship between TFF1 and chemo-resistance has not been investigated. The overall purpose of this project was to investigate the potential role of TFF1 in chemo-resistance in mammary carcinoma. TFF1 transfected MCF7 and T47D cells were utilised to analyse the effect of TFF1 over-expression on the cellular response to doxorubicin and paclitaxel. Forced expression of TFF1 induced resistance to doxorubicin and paclitaxel and depletion of endogenous TFF1 by siRNA re-sensitised the response. Therefore, antagonisation of TFF1 function could be used in breast cancer treatment to enhance the response to certain chemotherapeutic drugs, and to improve clinical outcome. en
dc.relation.ispartof Masters Thesis - University of Auckland en
dc.relation.isreferencedby UoA en
dc.rights Restricted Item. Full Text is available to authenticated members of The University of Auckland only. en
dc.rights Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. en
dc.rights.uri en
dc.subject chemoresistance en
dc.title Trefoil factor 1 and chemoresistance in breast cancer en
dc.type Thesis en The University of Auckland en Masters en
dc.rights.holder Copyright: The author en

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