dc.contributor.author |
Satokar, Vidit V |
|
dc.contributor.author |
Derraik, José GB |
|
dc.contributor.author |
Harwood, Matire |
|
dc.contributor.author |
Okesene-Gafa, Karaponi |
|
dc.contributor.author |
Beck, Kathryn |
|
dc.contributor.author |
Cameron-Smith, David |
|
dc.contributor.author |
Garg, Manohar L |
|
dc.contributor.author |
O'Sullivan, Justin M |
|
dc.contributor.author |
Sundborn, Gerhard |
|
dc.contributor.author |
Pundir, Shikha |
|
dc.contributor.author |
Mason, R Preston |
|
dc.contributor.author |
Cutfield, Wayne S |
|
dc.contributor.author |
Albert, Benjamin B |
|
dc.coverage.spatial |
United States |
|
dc.date.accessioned |
2023-08-04T03:41:49Z |
|
dc.date.available |
2023-08-04T03:41:49Z |
|
dc.date.issued |
2023-05 |
|
dc.identifier.citation |
(2023). American Journal of Clinical Nutrition, 117(5), 883-895. |
|
dc.identifier.issn |
0002-9165 |
|
dc.identifier.uri |
https://hdl.handle.net/2292/65357 |
|
dc.description.abstract |
<h4>Background</h4>Maternal obesity during pregnancy is associated with an increased risk of obesity and metabolic disease in the offspring. Supplementation with fish oil (FO), which is insulin sensitizing, during pregnancy in mothers with overweight or obesity may prevent the development of greater adiposity and metabolic dysfunction in their children.<h4>Objectives</h4>To determine the effects of FO supplementation throughout the second half of pregnancy and lactation in mothers with overweight or obesity on infant body composition and metabolism.<h4>Methods</h4>A double-blind randomized controlled trial of 6 g FO (3.55 g/d of n-3 PUFAs) compared with olive oil (control) from mid-pregnancy until 3 mo postpartum. Eligible women had singleton pregnancies at 12-20 wk of gestation, and BMI ≥ 25 kg/m<sup>2</sup>. The primary outcome was the infant body fat percentage (DXA scans) at 2 wk of age. Secondary outcomes included maternal metabolic markers during pregnancy, infant anthropometry at 2 wk and 3 mo of age, and metabolic markers at 3 mo.<h4>Results</h4>A total of 129 mothers were randomized, and 98 infants had a DXA scan at 2 wk.<h4>Primary outcome</h4>Imputed and nonimputed analyses showed no effects of FO supplementation on infant body fat percentage at age 2 wk.<h4>Secondary outcomes</h4>There were no treatment effects on infant outcomes at 2 wk, but FO infants had a higher BMI z-score (P = 0.025) and ponderal index (P = 0.017) at age 3 mo. FO supplementation lowered maternal triglycerides by 17% at 30 wk of pregnancy (P = 0.0002) and infant triglycerides by 21% at 3 mo of age (P = 0.016) but did not affect maternal or infant insulin resistance. The rate of emergency cesarean section was lower with FO supplementation [aRR = 0.38 (95%CI 0.16, 0.90); P = 0.027].<h4>Conclusions</h4>FO supplementation of mothers with overweight or obesity during pregnancy did not impact infant body composition. There is a need to follow up the offspring to determine whether the observed metabolic effects persist.<h4>Clinical trial registry number</h4>This study was registered with the Australian New Zealand Clinical Trials Registry (ACTRN12617001078347p). In addition, the Universal Trial Number, WHO, was obtained (U1111-1199-5860). |
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dc.format.medium |
Print-Electronic |
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dc.language |
eng |
|
dc.publisher |
Elsevier |
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dc.relation.ispartofseries |
The American journal of clinical nutrition |
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dc.rights |
Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. |
|
dc.rights.uri |
https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm |
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dc.subject |
Humans |
|
dc.subject |
Obesity |
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dc.subject |
Triglycerides |
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dc.subject |
Fish Oils |
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dc.subject |
Cesarean Section |
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dc.subject |
Double-Blind Method |
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dc.subject |
Body Composition |
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dc.subject |
Lactation |
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dc.subject |
Pregnancy |
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dc.subject |
Dietary Supplements |
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dc.subject |
Infant |
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dc.subject |
Australia |
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dc.subject |
Female |
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dc.subject |
Overweight |
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dc.subject |
fish oil supplementation |
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dc.subject |
maternal overweight/obesity |
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dc.subject |
n-3 polyunsaturated fatty acids |
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dc.subject |
Prevention |
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dc.subject |
Pediatric |
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dc.subject |
Clinical Trials and Supportive Activities |
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dc.subject |
Nutrition |
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dc.subject |
Clinical Research |
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dc.subject |
Metabolic and endocrine |
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dc.subject |
Reproductive health and childbirth |
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dc.subject |
3 Good Health and Well Being |
|
dc.subject |
09 Engineering |
|
dc.subject |
11 Medical and Health Sciences |
|
dc.title |
Fish oil supplementation during pregnancy and postpartum in mothers with overweight and obesity to improve body composition and metabolic health during infancy: A double-blind randomized controlled trial. |
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dc.type |
Journal Article |
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dc.identifier.doi |
10.1016/j.ajcnut.2023.02.007 |
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pubs.issue |
5 |
|
pubs.begin-page |
883 |
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pubs.volume |
117 |
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dc.date.updated |
2023-07-04T22:23:38Z |
|
dc.rights.holder |
Copyright: The authors |
en |
dc.identifier.pmid |
36781129 (pubmed) |
|
pubs.author-url |
https://www.ncbi.nlm.nih.gov/pubmed/36781129 |
|
pubs.end-page |
895 |
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pubs.publication-status |
Published |
|
dc.rights.accessrights |
http://purl.org/eprint/accessRights/RetrictedAccess |
en |
pubs.subtype |
Research Support, Non-U.S. Gov't |
|
pubs.subtype |
Randomized Controlled Trial |
|
pubs.subtype |
Journal Article |
|
pubs.elements-id |
950653 |
|
pubs.org-id |
Liggins Institute |
|
pubs.org-id |
Medical and Health Sciences |
|
pubs.org-id |
Population Health |
|
pubs.org-id |
Gen.Practice& Primary Hlthcare |
|
pubs.org-id |
Pacific Health |
|
pubs.org-id |
School of Medicine |
|
pubs.org-id |
Paediatrics Child & Youth Hlth |
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dc.identifier.eissn |
1938-3207 |
|
dc.identifier.pii |
S0002-9165(23)04153-9 |
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pubs.record-created-at-source-date |
2023-07-05 |
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pubs.online-publication-date |
2023-02-11 |
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