dc.contributor.author |
Lin, Joanne C |
|
dc.contributor.author |
Mueller, Christina |
|
dc.contributor.author |
Campbell, Kelsey A |
|
dc.contributor.author |
Thannickal, Halle H |
|
dc.contributor.author |
Daredia, Altamish F |
|
dc.contributor.author |
Sheriff, Sulaiman |
|
dc.contributor.author |
Maudsley, Andrew A |
|
dc.contributor.author |
Brunner, Robert C |
|
dc.contributor.author |
Younger, Jarred W |
|
dc.coverage.spatial |
United States |
|
dc.date.accessioned |
2023-09-18T21:24:21Z |
|
dc.date.available |
2023-09-18T21:24:21Z |
|
dc.date.issued |
2022-04 |
|
dc.identifier.citation |
(2022). Physical Medicine and Rehabilitation, 14(4), 472-485. |
|
dc.identifier.issn |
1934-1482 |
|
dc.identifier.uri |
https://hdl.handle.net/2292/65912 |
|
dc.description.abstract |
Background: Evidence suggests that neurometabolic abnormalities can persist after traumatic brain injury (TBI) and drive clinical symptoms such as fatigue and cognitive disruption. Magnetic resonance spectroscopy has been used to investigate metabolite abnormalities following TBI, but few studies have obtained data beyond the subacute stage or over large brain regions. Objective: To measure whole-brain metabolites in chronic stages of TBI. Design: Observational study. Setting: University. Participants: Eleven men with a moderate or severe TBI more than 12 months prior and 10 age-matched healthy controls completed whole-brain spectroscopic imaging. Main measures: Ratios of N-acetylaspartate (NAA), choline (CHO), and myo-inositol (MI) to creatine (CR) were measured in whole-brain gray and white matter as well as 64 brain regions of interest. Arterial spin labeling (ASL) data were also collected to investigate whether metabolite abnormalities were accompanied by differences in cerebral perfusion. Results: There were no differences in metabolite ratios within whole-brain gray and white matter regions of interest (ROIs). Linear regression showed lower NAA/CR in the white matter of the left occipital lobe but higher NAA/CR in the gray matter of the left parietal lobe. Metabolite abnormalities were observed in several brain regions in the TBI group including the corpus callosum, putamen, and posterior cingulate. However, none of the findings survived correction for multiple comparison. There were no differences in cerebral blood flow between patients and controls. Conclusion: Higher MI/CR may indicate ongoing gliosis, and it has been suggested that low CHO/CR at chronic time points may indicate cell death or lack of healthy turnover and repair. However, with the small sample size of this study, we caution against the over interpretation of our results. None of the findings within ROIs survived correction for multiple comparison. Thus, they may be considered possible avenues for future research in this area. |
|
dc.format.medium |
Print-Electronic |
|
dc.language |
eng |
|
dc.publisher |
Wiley |
|
dc.relation.ispartofseries |
PM & R : the journal of injury, function, and rehabilitation |
|
dc.rights |
Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. |
|
dc.rights |
This is the peer reviewed version of the following article: PM & R : the journal of injury, function, and rehabilitation 14(4):472-485 Apr 2022 which has been published in final form at http://doi.org/10.1002/pmrj.12623 This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions. This article may not be enhanced, enriched or otherwise transformed into a derivative work, without express permission from Wiley or by statutory rights under applicable legislation. Copyright notices must not be removed, obscured or modified. The article must be linked to Wiley’s version of record on Wiley Online Library and any embedding, framing or otherwise making available the article or pages thereof by third parties from platforms, services and websites other than Wiley Online Library must be prohibited. |
|
dc.rights.uri |
https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm |
|
dc.rights.uri |
https://authorservices.wiley.com/author-resources/Journal-Authors/licensing/self-archiving.html |
|
dc.subject |
Brain |
|
dc.subject |
Humans |
|
dc.subject |
Choline |
|
dc.subject |
Inositol |
|
dc.subject |
Creatine |
|
dc.subject |
Magnetic Resonance Imaging |
|
dc.subject |
Magnetic Resonance Spectroscopy |
|
dc.subject |
Male |
|
dc.subject |
Brain Injuries, Traumatic |
|
dc.subject |
32 Biomedical and Clinical Sciences |
|
dc.subject |
3202 Clinical Sciences |
|
dc.subject |
Traumatic Brain Injury (TBI) |
|
dc.subject |
Physical Injury - Accidents and Adverse Effects |
|
dc.subject |
Biomedical Imaging |
|
dc.subject |
Brain Disorders |
|
dc.subject |
Clinical Research |
|
dc.subject |
Neurosciences |
|
dc.subject |
Traumatic Head and Spine Injury |
|
dc.subject |
Science & Technology |
|
dc.subject |
Life Sciences & Biomedicine |
|
dc.subject |
Rehabilitation |
|
dc.subject |
Sport Sciences |
|
dc.subject |
MAGNETIC-RESONANCE-SPECTROSCOPY |
|
dc.subject |
LONG-TERM DISABILITY |
|
dc.subject |
UNITED-STATES |
|
dc.subject |
DIFFUSION |
|
dc.subject |
FATIGUE |
|
dc.subject |
ACTIVATION |
|
dc.subject |
BIOMARKER |
|
dc.subject |
NEURODEGENERATION |
|
dc.subject |
DISTRIBUTIONS |
|
dc.subject |
CONNECTIVITY |
|
dc.subject |
1103 Clinical Sciences |
|
dc.subject |
4201 Allied health and rehabilitation science |
|
dc.title |
Investigating whole-brain metabolite abnormalities in the chronic stages of moderate or severe traumatic brain injury |
|
dc.type |
Journal Article |
|
dc.identifier.doi |
10.1002/pmrj.12623 |
|
pubs.issue |
4 |
|
pubs.begin-page |
472 |
|
pubs.volume |
14 |
|
dc.date.updated |
2023-08-17T02:23:02Z |
|
dc.rights.holder |
Copyright: American Academy of Physical Medicine and Rehabilitation |
en |
dc.identifier.pmid |
33930238 (pubmed) |
|
pubs.author-url |
https://www.ncbi.nlm.nih.gov/pubmed/33930238 |
|
pubs.end-page |
485 |
|
pubs.publication-status |
Published |
|
dc.rights.accessrights |
http://purl.org/eprint/accessRights/OpenAccess |
en |
pubs.subtype |
Research Support, Non-U.S. Gov't |
|
pubs.subtype |
research-article |
|
pubs.subtype |
Journal Article |
|
pubs.subtype |
Research Support, N.I.H., Extramural |
|
pubs.subtype |
Observational Study |
|
pubs.elements-id |
857499 |
|
pubs.org-id |
Medical and Health Sciences |
|
pubs.org-id |
Pharmacy |
|
dc.identifier.eissn |
1934-1563 |
|
pubs.record-created-at-source-date |
2023-08-17 |
|
pubs.online-publication-date |
2021-06-17 |
|