Investigating whole-brain metabolite abnormalities in the chronic stages of moderate or severe traumatic brain injury

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dc.contributor.author Lin, Joanne C
dc.contributor.author Mueller, Christina
dc.contributor.author Campbell, Kelsey A
dc.contributor.author Thannickal, Halle H
dc.contributor.author Daredia, Altamish F
dc.contributor.author Sheriff, Sulaiman
dc.contributor.author Maudsley, Andrew A
dc.contributor.author Brunner, Robert C
dc.contributor.author Younger, Jarred W
dc.coverage.spatial United States
dc.date.accessioned 2023-09-18T21:24:21Z
dc.date.available 2023-09-18T21:24:21Z
dc.date.issued 2022-04
dc.identifier.citation (2022). Physical Medicine and Rehabilitation, 14(4), 472-485.
dc.identifier.issn 1934-1482
dc.identifier.uri https://hdl.handle.net/2292/65912
dc.description.abstract Background: Evidence suggests that neurometabolic abnormalities can persist after traumatic brain injury (TBI) and drive clinical symptoms such as fatigue and cognitive disruption. Magnetic resonance spectroscopy has been used to investigate metabolite abnormalities following TBI, but few studies have obtained data beyond the subacute stage or over large brain regions. Objective: To measure whole-brain metabolites in chronic stages of TBI. Design: Observational study. Setting: University. Participants: Eleven men with a moderate or severe TBI more than 12 months prior and 10 age-matched healthy controls completed whole-brain spectroscopic imaging. Main measures: Ratios of N-acetylaspartate (NAA), choline (CHO), and myo-inositol (MI) to creatine (CR) were measured in whole-brain gray and white matter as well as 64 brain regions of interest. Arterial spin labeling (ASL) data were also collected to investigate whether metabolite abnormalities were accompanied by differences in cerebral perfusion. Results: There were no differences in metabolite ratios within whole-brain gray and white matter regions of interest (ROIs). Linear regression showed lower NAA/CR in the white matter of the left occipital lobe but higher NAA/CR in the gray matter of the left parietal lobe. Metabolite abnormalities were observed in several brain regions in the TBI group including the corpus callosum, putamen, and posterior cingulate. However, none of the findings survived correction for multiple comparison. There were no differences in cerebral blood flow between patients and controls. Conclusion: Higher MI/CR may indicate ongoing gliosis, and it has been suggested that low CHO/CR at chronic time points may indicate cell death or lack of healthy turnover and repair. However, with the small sample size of this study, we caution against the over interpretation of our results. None of the findings within ROIs survived correction for multiple comparison. Thus, they may be considered possible avenues for future research in this area.
dc.format.medium Print-Electronic
dc.language eng
dc.publisher Wiley
dc.relation.ispartofseries PM & R : the journal of injury, function, and rehabilitation
dc.rights Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher.
dc.rights This is the peer reviewed version of the following article: PM & R : the journal of injury, function, and rehabilitation 14(4):472-485 Apr 2022 which has been published in final form at http://doi.org/10.1002/pmrj.12623 This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions. This article may not be enhanced, enriched or otherwise transformed into a derivative work, without express permission from Wiley or by statutory rights under applicable legislation. Copyright notices must not be removed, obscured or modified. The article must be linked to Wiley’s version of record on Wiley Online Library and any embedding, framing or otherwise making available the article or pages thereof by third parties from platforms, services and websites other than Wiley Online Library must be prohibited.
dc.rights.uri https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm
dc.rights.uri https://authorservices.wiley.com/author-resources/Journal-Authors/licensing/self-archiving.html
dc.subject Brain
dc.subject Humans
dc.subject Choline
dc.subject Inositol
dc.subject Creatine
dc.subject Magnetic Resonance Imaging
dc.subject Magnetic Resonance Spectroscopy
dc.subject Male
dc.subject Brain Injuries, Traumatic
dc.subject 32 Biomedical and Clinical Sciences
dc.subject 3202 Clinical Sciences
dc.subject Traumatic Brain Injury (TBI)
dc.subject Physical Injury - Accidents and Adverse Effects
dc.subject Biomedical Imaging
dc.subject Brain Disorders
dc.subject Clinical Research
dc.subject Neurosciences
dc.subject Traumatic Head and Spine Injury
dc.subject Science & Technology
dc.subject Life Sciences & Biomedicine
dc.subject Rehabilitation
dc.subject Sport Sciences
dc.subject MAGNETIC-RESONANCE-SPECTROSCOPY
dc.subject LONG-TERM DISABILITY
dc.subject UNITED-STATES
dc.subject DIFFUSION
dc.subject FATIGUE
dc.subject ACTIVATION
dc.subject BIOMARKER
dc.subject NEURODEGENERATION
dc.subject DISTRIBUTIONS
dc.subject CONNECTIVITY
dc.subject 1103 Clinical Sciences
dc.subject 4201 Allied health and rehabilitation science
dc.title Investigating whole-brain metabolite abnormalities in the chronic stages of moderate or severe traumatic brain injury
dc.type Journal Article
dc.identifier.doi 10.1002/pmrj.12623
pubs.issue 4
pubs.begin-page 472
pubs.volume 14
dc.date.updated 2023-08-17T02:23:02Z
dc.rights.holder Copyright: American Academy of Physical Medicine and Rehabilitation en
dc.identifier.pmid 33930238 (pubmed)
pubs.author-url https://www.ncbi.nlm.nih.gov/pubmed/33930238
pubs.end-page 485
pubs.publication-status Published
dc.rights.accessrights http://purl.org/eprint/accessRights/OpenAccess en
pubs.subtype Research Support, Non-U.S. Gov't
pubs.subtype research-article
pubs.subtype Journal Article
pubs.subtype Research Support, N.I.H., Extramural
pubs.subtype Observational Study
pubs.elements-id 857499
pubs.org-id Medical and Health Sciences
pubs.org-id Pharmacy
dc.identifier.eissn 1934-1563
pubs.record-created-at-source-date 2023-08-17
pubs.online-publication-date 2021-06-17


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