dc.contributor.author |
Bandamwar, Kalika L |
|
dc.contributor.author |
Garrett, Qian |
|
dc.contributor.author |
Papas, Eric B |
|
dc.coverage.spatial |
England |
|
dc.date.accessioned |
2023-10-03T01:18:24Z |
|
dc.date.available |
2023-10-03T01:18:24Z |
|
dc.date.issued |
2012-04 |
|
dc.identifier.citation |
(2012). Contact Lens and Anterior Eye, 35(2), 81-84. |
|
dc.identifier.issn |
1367-0484 |
|
dc.identifier.uri |
https://hdl.handle.net/2292/66047 |
|
dc.description.abstract |
<h4>Purpose</h4>To establish if sodium fluorescein (SFL) dye accumulation within intercellular spaces on the ocular surface contributes to the appearance of superficial punctate corneal staining.<h4>Methods</h4>Thirteen subjects bilaterally wore PureVision™ lenses that had been pre-soaked in ReNu MultiPlus® multipurpose solution. After 1h of lens wear, corneal staining with SFL was assessed using a standard slit-lamp technique. Participants who presented with bilateral, corneal staining were selected for further evaluation. A randomly selected eye was rinsed with saline three times. Fellow eyes (control) received no rinsing. After each rinse, the appearance of SFL staining was recorded without any further instillation of the dye. To eliminate any confounding effects of staining due to residual fluorescein in the tear menisci, corneal staining was induced in freshly excised, isolated, rabbit eyes by topical administration of 0.001% PHMB and staining, rinsing and grading were performed as above.<h4>Results</h4>Nine out of 13 subjects presented with bilateral diffuse corneal staining (mean grade±SD: 2.4±0.7). The mean staining grades in test and control eyes respectively after each of the three rinses were (1) 2.41±0.41, 2.25±0.69 (p=0.9); (2) 2.34±0.79, 2.1±0.83 (p=0.8); and (3) 1.71±0.65, 1.60±0.79 (p=0.6) there was no significant reduction in staining with rinsing (p>0.05) and no difference was observed between test and control eyes at any sampling-point. Similar observations made in ex vivo rabbit eyes replicated these results.<h4>Conclusions</h4>Pooling or accumulation of SFL solution within intercellular spaces does not appear to contribute to the appearance of superficial micropunctate corneal staining. |
|
dc.format.medium |
Print-Electronic |
|
dc.language |
eng |
|
dc.publisher |
Elsevier |
|
dc.relation.ispartofseries |
Contact lens & anterior eye : the journal of the British Contact Lens Association |
|
dc.rights |
Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. |
|
dc.rights.uri |
https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm |
|
dc.subject |
Cornea |
|
dc.subject |
Animals |
|
dc.subject |
Rabbits |
|
dc.subject |
Humans |
|
dc.subject |
Dry Eye Syndromes |
|
dc.subject |
Fluorescein |
|
dc.subject |
Contact Lens Solutions |
|
dc.subject |
Fluorescent Dyes |
|
dc.subject |
Staining and Labeling |
|
dc.subject |
Follow-Up Studies |
|
dc.subject |
Single-Blind Method |
|
dc.subject |
Contact Lenses, Hydrophilic |
|
dc.subject |
Adult |
|
dc.subject |
Young Adult |
|
dc.subject |
32 Biomedical and Clinical Sciences |
|
dc.subject |
3212 Ophthalmology and Optometry |
|
dc.subject |
Clinical Research |
|
dc.subject |
Eye Disease and Disorders of Vision |
|
dc.subject |
Eye |
|
dc.subject |
Science & Technology |
|
dc.subject |
Life Sciences & Biomedicine |
|
dc.subject |
Ophthalmology |
|
dc.subject |
Corneal staining |
|
dc.subject |
Pooling |
|
dc.subject |
1113 Opthalmology and Optometry |
|
dc.title |
Mechanisms of superficial micropunctate corneal staining with sodium fluorescein: the contribution of pooling |
|
dc.type |
Journal Article |
|
dc.identifier.doi |
10.1016/j.clae.2011.08.008 |
|
pubs.issue |
2 |
|
pubs.begin-page |
81 |
|
pubs.volume |
35 |
|
dc.date.updated |
2023-09-06T00:44:42Z |
|
dc.rights.holder |
Copyright: British Contact Lens Association |
en |
dc.identifier.pmid |
21917503 (pubmed) |
|
pubs.author-url |
https://www.ncbi.nlm.nih.gov/pubmed/21917503 |
|
pubs.end-page |
84 |
|
pubs.publication-status |
Published |
|
dc.rights.accessrights |
http://purl.org/eprint/accessRights/RetrictedAccess |
en |
pubs.subtype |
Comparative Study |
|
pubs.subtype |
Randomized Controlled Trial |
|
pubs.subtype |
Journal Article |
|
pubs.elements-id |
926068 |
|
pubs.org-id |
Medical and Health Sciences |
|
pubs.org-id |
School of Medicine |
|
pubs.org-id |
Ophthalmology Department |
|
dc.identifier.eissn |
1476-5411 |
|
dc.identifier.pii |
S1367-0484(11)00123-8 |
|
pubs.record-created-at-source-date |
2023-09-06 |
|
pubs.online-publication-date |
2011-09-13 |
|