dc.contributor.author |
James, Joanna L |
|
dc.contributor.author |
Boss, Anna L |
|
dc.contributor.author |
Sun, Cherry |
|
dc.contributor.author |
Allerkamp, Hanna H |
|
dc.contributor.author |
Clark, Alys R |
|
dc.coverage.spatial |
Netherlands |
|
dc.date.accessioned |
2023-11-03T02:32:27Z |
|
dc.date.available |
2023-11-03T02:32:27Z |
|
dc.date.issued |
2022-07 |
|
dc.identifier.citation |
(2022). Placenta, 125, 68-77. |
|
dc.identifier.issn |
0143-4004 |
|
dc.identifier.uri |
https://hdl.handle.net/2292/66403 |
|
dc.description.abstract |
Early placental development lays the foundation of a healthy pregnancy, and numerous tightly regulated processes must occur for the placenta to meet the increasing nutrient and oxygen exchange requirements of the growing fetus later in gestation. Inadequacies in early placental development can result in disorders such as fetal growth restriction that do not present clinically until the second half of gestation. Indeed, growth restricted placentae exhibit impaired placental development and function, including reduced overall placental size, decreased branching of villi and the blood vessels within them, altered trophoblast function, and impaired uterine vascular remodelling, which together combine to reduce placental exchange capacity. This review explores the importance of early placental development across multiple anatomical aspects of placentation, from the stem cells and lineage hierarchies from which villous core cells and trophoblasts arise, through extravillous trophoblast invasion and spiral artery remodelling, and finally remodelling of the larger uterine vessels. |
|
dc.format.medium |
Print-Electronic |
|
dc.language |
eng |
|
dc.publisher |
Elsevier |
|
dc.relation.ispartofseries |
Placenta |
|
dc.rights |
Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. |
|
dc.rights.uri |
https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm |
|
dc.subject |
Arteries |
|
dc.subject |
Stem Cells |
|
dc.subject |
Trophoblasts |
|
dc.subject |
Placenta |
|
dc.subject |
Humans |
|
dc.subject |
Pregnancy |
|
dc.subject |
Placentation |
|
dc.subject |
Female |
|
dc.subject |
Extravillous trophoblast |
|
dc.subject |
Fetal growth restriction |
|
dc.subject |
Placental development |
|
dc.subject |
Placental vasculature |
|
dc.subject |
Spiral artery remodelling |
|
dc.subject |
Trophoblast stem cell |
|
dc.subject |
3215 Reproductive Medicine |
|
dc.subject |
32 Biomedical and Clinical Sciences |
|
dc.subject |
Infant Mortality |
|
dc.subject |
Stem Cell Research |
|
dc.subject |
Preterm, Low Birth Weight and Health of the Newborn |
|
dc.subject |
Stem Cell Research - Nonembryonic - Non-Human |
|
dc.subject |
Perinatal Period - Conditions Originating in Perinatal Period |
|
dc.subject |
Pediatric |
|
dc.subject |
Stem Cell Research - Nonembryonic - Human |
|
dc.subject |
Contraception/Reproduction |
|
dc.subject |
2.1 Biological and endogenous factors |
|
dc.subject |
2 Aetiology |
|
dc.subject |
1 Underpinning research |
|
dc.subject |
1.1 Normal biological development and functioning |
|
dc.subject |
Reproductive health and childbirth |
|
dc.subject |
Science & Technology |
|
dc.subject |
Life Sciences & Biomedicine |
|
dc.subject |
Developmental Biology |
|
dc.subject |
Obstetrics & Gynecology |
|
dc.subject |
Reproductive Biology |
|
dc.subject |
MESENCHYMAL STROMAL CELLS |
|
dc.subject |
FETAL-GROWTH RESTRICTION |
|
dc.subject |
LOW SHEAR-STRESS |
|
dc.subject |
RNA-SEQ REVEALS |
|
dc.subject |
1ST TRIMESTER |
|
dc.subject |
EARLY-PREGNANCY |
|
dc.subject |
INTERVILLOUS SPACE |
|
dc.subject |
ENDOTHELIAL-CELLS |
|
dc.subject |
BLOOD-FLOW |
|
dc.subject |
0601 Biochemistry and Cell Biology |
|
dc.subject |
1103 Clinical Sciences |
|
dc.subject |
1114 Paediatrics and Reproductive Medicine |
|
dc.subject |
3101 Biochemistry and cell biology |
|
dc.subject |
4204 Midwifery |
|
dc.title |
From stem cells to spiral arteries: A journey through early placental development |
|
dc.type |
Journal Article |
|
dc.identifier.doi |
10.1016/j.placenta.2021.11.004 |
|
pubs.begin-page |
68 |
|
pubs.volume |
125 |
|
dc.date.updated |
2023-10-24T21:51:06Z |
|
dc.rights.holder |
Copyright: Elsevier Ltd |
en |
dc.identifier.pmid |
34819240 (pubmed) |
|
pubs.author-url |
https://www.sciencedirect.com/science/article/pii/S0143400421006482?via%3Dihub |
|
pubs.end-page |
77 |
|
pubs.publication-status |
Published |
|
dc.rights.accessrights |
http://purl.org/eprint/accessRights/RetrictedAccess |
en |
pubs.subtype |
Research Support, Non-U.S. Gov't |
|
pubs.subtype |
Review |
|
pubs.subtype |
Journal Article |
|
pubs.elements-id |
875064 |
|
pubs.org-id |
Bioengineering Institute |
|
pubs.org-id |
Medical and Health Sciences |
|
pubs.org-id |
School of Medicine |
|
pubs.org-id |
Obstetrics and Gynaecology |
|
pubs.org-id |
ABI Associates |
|
dc.identifier.eissn |
1532-3102 |
|
dc.identifier.pii |
S0143-4004(21)00648-2 |
|
pubs.record-created-at-source-date |
2023-10-25 |
|
pubs.online-publication-date |
2021-11-19 |
|