dc.contributor.author |
James, Joanna L |
|
dc.contributor.author |
Lissaman, Abbey |
|
dc.contributor.author |
Nursalim, Yohanes NS |
|
dc.contributor.author |
Chamley, Lawrence W |
|
dc.coverage.spatial |
Switzerland |
|
dc.date.accessioned |
2023-11-05T22:33:06Z |
|
dc.date.available |
2023-11-05T22:33:06Z |
|
dc.date.issued |
2022-06 |
|
dc.identifier.citation |
(2022). Cellular and Molecular Life Sciences, 79(7), 384-. |
|
dc.identifier.issn |
1420-682X |
|
dc.identifier.uri |
https://hdl.handle.net/2292/66438 |
|
dc.description.abstract |
The use of in vitro tools to study trophoblast differentiation and function is essential to improve understanding of normal and abnormal placental development. The relative accessibility of human placentae enables the use of primary trophoblasts and placental explants in a range of in vitro systems. Recent advances in stem cell models, three-dimensional organoid cultures, and organ-on-a-chip systems have further shed light on the complex microenvironment and cell-cell crosstalk involved in placental development. However, understanding each model's strengths and limitations, and which in vivo aspects of human placentation in vitro data acquired does, or does not, accurately reflect, is key to interpret findings appropriately. To help researchers use and design anatomically accurate culture models, this review both outlines our current understanding of placental development, and critically considers the range of established and emerging culture models used to study this, with a focus on those derived from primary tissue. |
|
dc.format.medium |
Electronic |
|
dc.language |
eng |
|
dc.publisher |
Springer Nature |
|
dc.relation.ispartofseries |
Cellular and molecular life sciences : CMLS |
|
dc.rights |
Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. |
|
dc.rights.uri |
https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm |
|
dc.rights.uri |
https://creativecommons.org/licenses/by/4.0/ |
|
dc.subject |
Stem Cells |
|
dc.subject |
Trophoblasts |
|
dc.subject |
Placenta |
|
dc.subject |
Humans |
|
dc.subject |
Cell Differentiation |
|
dc.subject |
Pregnancy |
|
dc.subject |
Placentation |
|
dc.subject |
Female |
|
dc.subject |
Extravillous trophoblast |
|
dc.subject |
In vitro models |
|
dc.subject |
Placental development |
|
dc.subject |
Syncytiotrophoblast |
|
dc.subject |
Trophoblast stem cell |
|
dc.subject |
3215 Reproductive Medicine |
|
dc.subject |
32 Biomedical and Clinical Sciences |
|
dc.subject |
Stem Cell Research |
|
dc.subject |
Pediatric |
|
dc.subject |
Contraception/Reproduction |
|
dc.subject |
Biotechnology |
|
dc.subject |
Clinical Research |
|
dc.subject |
Stem Cell Research - Nonembryonic - Human |
|
dc.subject |
1.1 Normal biological development and functioning |
|
dc.subject |
1 Underpinning research |
|
dc.subject |
Reproductive health and childbirth |
|
dc.subject |
Science & Technology |
|
dc.subject |
Life Sciences & Biomedicine |
|
dc.subject |
Biochemistry & Molecular Biology |
|
dc.subject |
Cell Biology |
|
dc.subject |
NATURAL-KILLER-CELLS |
|
dc.subject |
EXTRAVILLOUS TROPHOBLAST INVASION |
|
dc.subject |
IN-VITRO DIFFERENTIATION |
|
dc.subject |
LOW SHEAR-STRESS |
|
dc.subject |
1ST TRIMESTER |
|
dc.subject |
STEM-CELLS |
|
dc.subject |
GROWTH RESTRICTION |
|
dc.subject |
ANCHORING VILLI |
|
dc.subject |
EXPRESSION |
|
dc.subject |
0601 Biochemistry and Cell Biology |
|
dc.subject |
0606 Physiology |
|
dc.subject |
1103 Clinical Sciences |
|
dc.subject |
3101 Biochemistry and cell biology |
|
dc.subject |
3205 Medical biochemistry and metabolomics |
|
dc.subject |
3211 Oncology and carcinogenesis |
|
dc.title |
Modelling human placental villous development: designing cultures that reflect anatomy |
|
dc.type |
Journal Article |
|
dc.identifier.doi |
10.1007/s00018-022-04407-x |
|
pubs.issue |
7 |
|
pubs.begin-page |
384 |
|
pubs.volume |
79 |
|
dc.date.updated |
2023-10-24T21:52:37Z |
|
dc.rights.holder |
Copyright: The authors |
en |
dc.identifier.pmid |
35753002 (pubmed) |
|
pubs.author-url |
https://www.ncbi.nlm.nih.gov/pubmed/35753002 |
|
pubs.publication-status |
Published |
|
dc.rights.accessrights |
http://purl.org/eprint/accessRights/OpenAccess |
en |
pubs.subtype |
review-article |
|
pubs.subtype |
Review |
|
pubs.subtype |
Journal Article |
|
pubs.elements-id |
910321 |
|
pubs.org-id |
Medical and Health Sciences |
|
pubs.org-id |
Medical Sciences |
|
pubs.org-id |
School of Medicine |
|
pubs.org-id |
Obstetrics and Gynaecology |
|
dc.identifier.eissn |
1420-9071 |
|
dc.identifier.pii |
10.1007/s00018-022-04407-x |
|
pubs.number |
384 |
|
pubs.record-created-at-source-date |
2023-10-25 |
|
pubs.online-publication-date |
2022-06-26 |
|