dc.contributor.author |
Darroch, Hannah |
|
dc.contributor.author |
Astin, Jonathan W |
|
dc.contributor.author |
Hall, Christopher J |
|
dc.coverage.spatial |
United States |
|
dc.date.accessioned |
2023-12-04T02:58:53Z |
|
dc.date.available |
2023-12-04T02:58:53Z |
|
dc.date.issued |
2022-07 |
|
dc.identifier.citation |
(2022). Developmental and Comparative Immunology, 132, 104400-. |
|
dc.identifier.issn |
0145-305X |
|
dc.identifier.uri |
https://hdl.handle.net/2292/66671 |
|
dc.description.abstract |
Once thought to be a feature exclusive to lymphocyte-driven adaptive immunity, immune memory has also been shown to operate as part of the innate immune system following infection to provide an elevated host response to subsequent pathogenic challenge. This evolutionarily conserved process, termed 'trained immunity', enables cells of the innate immune system to 'remember' previous pathogen encounters and mount stronger responses to the same, or different, pathogens after returning to a non-activated state. Here we show that challenging larval zebrafish, that exclusively rely on innate immunity, with live or heat-killed Salmonella typhimurium provides protection to subsequent infection with either Salmonella typhimurium or Streptococcus iniae, that lasts for at least 12 days. We also show that larvae injected with β-glucan, the well-known trigger of trained immunity, demonstrate enhanced survival to similar live bacterial infections, a phenotype supported by increased cxcl8 expression and neutrophil recruitment to the infection site. These results support the conservation of a trained immunity-like phenotype in larval zebrafish and provide a foundation to exploit the experimental attributes of larval zebrafish to further understand this form of immunological memory. |
|
dc.format.medium |
Print-Electronic |
|
dc.language |
eng |
|
dc.publisher |
Elsevier |
|
dc.relation.ispartofseries |
Developmental and comparative immunology |
|
dc.rights |
Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. |
|
dc.rights.uri |
https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm |
|
dc.subject |
Animals |
|
dc.subject |
Zebrafish |
|
dc.subject |
Salmonella typhimurium |
|
dc.subject |
beta-Glucans |
|
dc.subject |
Larva |
|
dc.subject |
Immunity, Innate |
|
dc.subject |
Immunological memory |
|
dc.subject |
Infection |
|
dc.subject |
Innate immunity |
|
dc.subject |
Trained immunity |
|
dc.subject |
3207 Medical Microbiology |
|
dc.subject |
32 Biomedical and Clinical Sciences |
|
dc.subject |
3204 Immunology |
|
dc.subject |
Vaccine Related |
|
dc.subject |
Emerging Infectious Diseases |
|
dc.subject |
Biodefense |
|
dc.subject |
Infectious Diseases |
|
dc.subject |
Foodborne Illness |
|
dc.subject |
Prevention |
|
dc.subject |
2 Aetiology |
|
dc.subject |
2.1 Biological and endogenous factors |
|
dc.subject |
2.2 Factors relating to the physical environment |
|
dc.subject |
Inflammatory and immune system |
|
dc.subject |
Science & Technology |
|
dc.subject |
Life Sciences & Biomedicine |
|
dc.subject |
Fisheries |
|
dc.subject |
Immunology |
|
dc.subject |
Veterinary Sciences |
|
dc.subject |
Zoology |
|
dc.subject |
HEMATOPOIETIC STEM |
|
dc.subject |
STAPHYLOCOCCUS-AUREUS |
|
dc.subject |
GENE-EXPRESSION |
|
dc.subject |
DANIO-RERIO |
|
dc.subject |
BCG |
|
dc.subject |
CELLS |
|
dc.subject |
REINFECTION |
|
dc.subject |
MACROPHAGES |
|
dc.subject |
MODULATION |
|
dc.subject |
1107 Immunology |
|
dc.title |
Towards a new model of trained immunity: Exposure to bacteria and β-glucan protects larval zebrafish against subsequent infections |
|
dc.type |
Journal Article |
|
dc.identifier.doi |
10.1016/j.dci.2022.104400 |
|
pubs.begin-page |
104400 |
|
pubs.volume |
132 |
|
dc.date.updated |
2023-11-22T18:56:40Z |
|
dc.rights.holder |
Copyright: Elsevier Ltd |
en |
dc.identifier.pmid |
35367515 (pubmed) |
|
pubs.author-url |
https://www.ncbi.nlm.nih.gov/pubmed/35367515 |
|
pubs.publication-status |
Published |
|
dc.rights.accessrights |
http://purl.org/eprint/accessRights/RetrictedAccess |
en |
pubs.subtype |
Research Support, Non-U.S. Gov't |
|
pubs.subtype |
Journal Article |
|
pubs.elements-id |
895747 |
|
pubs.org-id |
Medical and Health Sciences |
|
pubs.org-id |
Medical Sciences |
|
pubs.org-id |
Molecular Medicine |
|
dc.identifier.eissn |
1879-0089 |
|
dc.identifier.pii |
S0145-305X(22)00062-3 |
|
pubs.number |
104400 |
|
pubs.record-created-at-source-date |
2023-11-23 |
|
pubs.online-publication-date |
2022-03-31 |
|