dc.contributor.author |
Sharabiani, Mansour TA |
|
dc.contributor.author |
Fiorentino, Francesca |
|
dc.contributor.author |
Angelini, Gianni D |
|
dc.contributor.author |
Patel, Nishith N |
|
dc.coverage.spatial |
England |
|
dc.date.accessioned |
2023-12-05T23:05:24Z |
|
dc.date.available |
2023-12-05T23:05:24Z |
|
dc.date.issued |
2016-01 |
|
dc.identifier.citation |
(2016). Open Heart, 3(1), e000338-. |
|
dc.identifier.issn |
2053-3624 |
|
dc.identifier.uri |
https://hdl.handle.net/2292/66755 |
|
dc.description.abstract |
Objective: Surgical aortic valve replacement (AVR) remains the gold standard therapy for severe aortic stenosis. Long-term survival data following AVR is required. Our objective was to provide a detailed contemporary benchmark of long-term survival following AVR among elderly patients (≥65 years) in the UK. Methods: We conducted a retrospective cohort study of 1815 adult patients undergoing surgical AVR± coronary artery bypass graft (CABG) surgery at a single UK centre between 1996 and 2011. Our main outcome was patient survival, which was assessed by linkage to census records at the Office for National Statistics. Results: The mean age of the cohort was 75 (±5.6) years. Patients in the AVR alone group had a slightly higher median survival of 10.9 (95% CI 10.5 to 11.8) years than the AVR+CABG group which had a median survival of 9.6 (95% CI 8.7 to 10.1) years (p=0.001 of log-rank test (LRT) for equality of survivor functions). The presence of chronic kidney disease, severely impaired left ventricular function or being a current smoker were each associated with a ≥50% increased risk of long-term mortality. Comparison of our study cohort patients and the reference (operation year, age and gender matched) UK population suggested no difference in survival probability up to 8 years (p=0.55). However, for longer periods of follow-up, the difference became increasingly significant (p<0.0001). Conclusions: Long-term survival following surgical AVR in patients over 65 years of age is excellent and up to 8 years is comparable to the matched general population. |
|
dc.format.medium |
Electronic-eCollection |
|
dc.language |
eng |
|
dc.publisher |
BMJ |
|
dc.relation.ispartofseries |
Open heart |
|
dc.rights |
Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. |
|
dc.rights.uri |
https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm |
|
dc.rights.uri |
http://creativecommons.org/licenses/by/4.0/ |
|
dc.subject |
QUALITY OF CARE AND OUTCOMES |
|
dc.subject |
32 Biomedical and Clinical Sciences |
|
dc.subject |
3201 Cardiovascular Medicine and Haematology |
|
dc.subject |
3202 Clinical Sciences |
|
dc.subject |
Clinical Research |
|
dc.subject |
Aging |
|
dc.subject |
Cardiovascular |
|
dc.subject |
Atherosclerosis |
|
dc.subject |
Heart Disease |
|
dc.subject |
Transplantation |
|
dc.subject |
6 Evaluation of treatments and therapeutic interventions |
|
dc.subject |
2.4 Surveillance and distribution |
|
dc.subject |
6.4 Surgery |
|
dc.subject |
2 Aetiology |
|
dc.subject |
Science & Technology |
|
dc.subject |
Life Sciences & Biomedicine |
|
dc.subject |
Cardiac & Cardiovascular Systems |
|
dc.subject |
Cardiovascular System & Cardiology |
|
dc.subject |
VALVULAR HEART-DISEASE |
|
dc.subject |
ELDERLY-PATIENTS |
|
dc.subject |
TRANSCATHETER |
|
dc.subject |
OUTCOMES |
|
dc.subject |
RISK |
|
dc.subject |
IMPLANTATION |
|
dc.subject |
ASSOCIATION |
|
dc.subject |
STENOSIS |
|
dc.subject |
SOCIETY |
|
dc.subject |
EUROPE |
|
dc.title |
Long-term survival after surgical aortic valve replacement among patients over 65 years of age |
|
dc.type |
Journal Article |
|
dc.identifier.doi |
10.1136/openhrt-2015-000338 |
|
pubs.issue |
1 |
|
pubs.begin-page |
e000338 |
|
pubs.volume |
3 |
|
dc.date.updated |
2023-11-04T08:42:29Z |
|
dc.rights.holder |
Copyright: The authors |
en |
dc.identifier.pmid |
27042318 (pubmed) |
|
pubs.author-url |
https://openheart.bmj.com/content/3/1/e000338 |
|
pubs.publication-status |
Published |
|
dc.rights.accessrights |
http://purl.org/eprint/accessRights/OpenAccess |
en |
pubs.subtype |
Research Support, Non-U.S. Gov't |
|
pubs.subtype |
research-article |
|
pubs.subtype |
Journal Article |
|
pubs.elements-id |
991362 |
|
pubs.org-id |
Medical and Health Sciences |
|
pubs.org-id |
School of Medicine |
|
pubs.org-id |
Surgery Department |
|
dc.identifier.eissn |
2053-3624 |
|
dc.identifier.pii |
openhrt-2015-000338 |
|
pubs.number |
UNSP e000338 |
|
pubs.record-created-at-source-date |
2023-11-04 |
|
pubs.online-publication-date |
2016-03-25 |
|