dc.contributor.author |
Swarnamali, H |
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dc.contributor.author |
Cree, J |
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dc.contributor.author |
Lim, JJ |
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dc.contributor.author |
Jayaprakash, J |
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dc.contributor.author |
Zeng, E |
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dc.contributor.author |
Sharma, P |
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dc.contributor.author |
Shrestha, A |
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dc.contributor.author |
Rosanowski, S |
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dc.contributor.author |
Fraser, K |
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dc.contributor.author |
Butowski, N |
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dc.contributor.author |
Tegetmeyer, H |
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dc.contributor.author |
Young, Y |
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dc.contributor.author |
Altermann, E |
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dc.contributor.author |
Nivins, S |
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dc.contributor.author |
Gearry, R |
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dc.contributor.author |
Roy, NC |
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dc.contributor.author |
Mithen, RF |
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dc.contributor.author |
Barnett, MPG |
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dc.contributor.author |
Milan, AM |
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dc.coverage.spatial |
Massey University, Albany, Tāmaki Makaurau, Auckland, New Zealand |
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dc.date.accessioned |
2024-01-10T01:30:36Z |
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dc.date.available |
2024-01-10T01:30:36Z |
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dc.date.issued |
2023-11-28 |
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dc.identifier.citation |
(2023, December 28-1). [Conference item]. Nutrition and Wellbeing in Oceania, Joint Conference of the Nutrition Societies of New Zealand and Australia 2023, Massey University, Albany, Tāmaki Makaurau, Auckland, New Zealand, 28 Dec 2023 - 01 Dec 2023. |
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dc.identifier.uri |
https://hdl.handle.net/2292/67160 |
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dc.description.abstract |
The diagnosis of functional constipation (FC) relies on patient-reported outcomes evaluated as criteria based on the clustering of symptoms. Although the ROME IV criteria for FC diagnosis is relevant for a multicultural population [1], how an individual's lifestyle, environment and culture may influence the pathophysiology of FC remains a gap in our knowledge. Building on insights into mechanisms underpinning disorders of gut-brain interactions (formerly functional gastrointestinal disorders) in the COMFORT Cohort [2], this study aimed to investigate the differences in gastrointestinal (GI) symptom scores among participants with FC in comparison to healthy controls between Chinese and non-Chinese New Zealanders. The Gastrointestinal Understanding of Functional Constipation In an Urban Chinese and Urban non-Chinese New Zealander Cohort (GUTFIT) study was a longitudinal cohort study, which aimed to determine a comprehensive profile of characteristics and biological markers of FC between Chinese and non-Chinese New Zealanders. Chinese (classified according to maternal and paternal ethnicity) or non-Chinese (mixed ethnicities) adults living in Auckland classified as with or without FC based on ROME IV were enrolled. Monthly assessment (for 3 months) of GI symptoms, anthropometry, quality of life, diet, and biological samples were assessed monthly over March to June 2023. Demographics were obtained through a self-reported questionnaires and GI symptoms were assessed using the Gastrointestinal Symptom Rating Scale (GSRS) and Structured Assessment of Gastrointestinal Symptoms Scale (SAGIS). This analysis is a cross-sectional assessment of patient-reported outcomes of GI symptoms. Of 78 enrolled participants, 66 completed the study (male, n=10; female, n=56) and were distributed across: Chinese with FC (Ch-FC; n=11), Chinese control (Ch-CON; n=19), non-Chinese with FC (NCh-FC; n=16), non-Chinese control (NCh-CON; n=20). Mean (SD) age, body mass index, and waist circumference were 40±9 years, 22.7±2.5 kg/m2, and 78.0±7.6 cm, respectively. Ethnicity did not impact SAGIS domain scores for GI symptoms (Ethnicity x FC severity interaction p>0.05). Yet, the constipation symptoms domain of the GSRS was scored differently depending on ethnicity and FC status (Ethnicity x FC interaction p<0.05). In post hoc comparison, NCh-FC tended to have higher GSRS constipation severity scores than Ch-FC (3.4 ±1.0 versus 3.8 ±0.8 /8, p<0.1). Although constipation symptom severity tended to be higher in NCh-FC, on the whole, ethnicity did not explain variation in this cohort. FC status was a more important predictor of GI symptoms scores. Future research will assess differences in symptom burden to explore ethnicity-specific characteristics of FC.
References
1. Schmulson, M. J., & Drossman, D. A. (2017). J Neurogastroenterol Motil, 23(2), 151.
2. Heenan P, Creemers RH, Sharma S, et al. (2020) Inflamm Intest Dis 5,132-143.
Keywords
Disorders of Gut-Brain Interactions; Functional Gastrointestinal Disorders; Ethnicities; Gastrointestinal Symptoms scores; ROME IV; Functional Constipation |
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dc.relation.ispartof |
Nutrition and Wellbeing in Oceania, Joint Conference of the Nutrition Societies of New Zealand and Australia 2023 |
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dc.rights |
Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. |
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dc.rights.uri |
https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm |
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dc.title |
The GUTFIT cohort: Understanding of different gastrointestinal symptoms score variation between Chines and non-Chines individuals with functional constipation |
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dc.type |
Poster |
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dc.date.updated |
2023-12-31T02:08:52Z |
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dc.rights.holder |
Copyright: The authors |
en |
pubs.author-url |
https://img1.wsimg.com/blobby/go/029eb977-da77-4ac2-b0ba-24f11828e130/Conference Handbook.pdf |
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pubs.finish-date |
2023-12-01 |
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pubs.start-date |
2023-12-28 |
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dc.rights.accessrights |
http://purl.org/eprint/accessRights/OpenAccess |
en |
pubs.subtype |
Conference Poster |
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pubs.elements-id |
1005614 |
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pubs.org-id |
Liggins Institute |
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pubs.record-created-at-source-date |
2023-12-31 |
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