dc.contributor.author |
Moammer, Hussam |
|
dc.contributor.author |
Bai, Jizhong |
|
dc.contributor.author |
Jones, Timothy LM |
|
dc.contributor.author |
Ward, Marie |
|
dc.contributor.author |
Barrett, Caroyln |
|
dc.contributor.author |
Crossman, David J |
|
dc.coverage.spatial |
England |
|
dc.date.accessioned |
2024-03-11T01:23:19Z |
|
dc.date.available |
2024-03-11T01:23:19Z |
|
dc.date.issued |
2023-12 |
|
dc.identifier.citation |
(2023). Interface Focus, 13(6), 20230047-. |
|
dc.identifier.issn |
2042-8898 |
|
dc.identifier.uri |
https://hdl.handle.net/2292/67604 |
|
dc.description.abstract |
Transverse (t)-tubule remodelling is a prominent feature of heart failure with reduced ejection fraction (HFrEF). In our previous research, we identified an increased amount of collagen within the t-tubules of HFrEF patients, suggesting fibrosis could contribute to the remodelling of t-tubules. In this research, we tested this hypothesis in a rodent model of myocardial infarction induced heart failure that was treated with the anti-fibrotic pirfenidone. Confocal microscopy demonstrated loss of t-tubules within the border zone region of the infarct. This was documented as a reduction in t-tubule frequency, area, length, and transverse elements. Eight weeks of pirfenidone treatment was able to significantly increase the area and length of the t-tubules within the border zone. Echocardiography showed no improvement with pirfenidone treatment. Surprisingly, pirfenidone significantly increased the thickness of the t-tubules in the remote left ventricle of heart failure animals. Dilation of t-tubules is a common feature in heart failure suggesting this may negatively impact function but there was no functional loss associated with pirfenidone treatment. However, due to the relatively short duration of treatment compared to that used clinically, the impact of long-term treatment on t-tubule structure should be investigated in future studies. |
|
dc.format.medium |
Electronic-eCollection |
|
dc.language |
eng |
|
dc.publisher |
The Royal Society |
|
dc.relation.ispartofseries |
Interface focus |
|
dc.rights |
Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. |
|
dc.rights.uri |
https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm |
|
dc.rights.uri |
http://creativecommons.org/licenses/by/4.0/ |
|
dc.subject |
fibrosis |
|
dc.subject |
heart failure |
|
dc.subject |
myocardial infarction |
|
dc.subject |
pirfenidone |
|
dc.subject |
transverse tubules |
|
dc.subject |
3208 Medical Physiology |
|
dc.subject |
32 Biomedical and Clinical Sciences |
|
dc.subject |
Heart Disease |
|
dc.subject |
Cardiovascular |
|
dc.subject |
Heart Disease - Coronary Heart Disease |
|
dc.subject |
Science & Technology |
|
dc.subject |
Life Sciences & Biomedicine |
|
dc.subject |
Biology |
|
dc.subject |
Life Sciences & Biomedicine - Other Topics |
|
dc.subject |
HEART-FAILURE |
|
dc.subject |
VENTRICULAR MYOCYTES |
|
dc.subject |
T-TUBULES |
|
dc.subject |
INTERSTITIAL FIBROSIS |
|
dc.subject |
REDUCED SYNCHRONY |
|
dc.subject |
FAILING HUMAN |
|
dc.subject |
CA2+ RELEASE |
|
dc.subject |
IMPACT |
|
dc.title |
Pirfenidone increases transverse tubule length in the infarcted rat myocardium |
|
dc.type |
Journal Article |
|
dc.identifier.doi |
10.1098/rsfs.2023.0047 |
|
pubs.issue |
6 |
|
pubs.begin-page |
20230047 |
|
pubs.volume |
13 |
|
dc.date.updated |
2024-02-13T20:56:50Z |
|
dc.rights.holder |
Copyright: The authors |
en |
dc.identifier.pmid |
38106917 (pubmed) |
|
pubs.author-url |
https://royalsocietypublishing.org/doi/10.1098/rsfs.2023.0047#d1e1692 |
|
pubs.publication-status |
Published |
|
dc.rights.accessrights |
http://purl.org/eprint/accessRights/OpenAccess |
en |
pubs.subtype |
research-article |
|
pubs.subtype |
Journal Article |
|
pubs.elements-id |
1004800 |
|
pubs.org-id |
Medical and Health Sciences |
|
pubs.org-id |
Medical Sciences |
|
pubs.org-id |
Physiology Division |
|
dc.identifier.eissn |
2042-8901 |
|
dc.identifier.pii |
rsfs20230047 |
|
pubs.number |
ARTN 20230047 |
|
pubs.record-created-at-source-date |
2024-02-14 |
|
pubs.online-publication-date |
2023-12-15 |
|