dc.contributor.author |
Lyons-Reid, Jaz |
|
dc.contributor.author |
Derraik, José GB |
|
dc.contributor.author |
Kenealy, Timothy |
|
dc.contributor.author |
Albert, Benjamin B |
|
dc.contributor.author |
Ramos Nieves, J Manuel |
|
dc.contributor.author |
Monnard, Cathriona R |
|
dc.contributor.author |
Titcombe, Phil |
|
dc.contributor.author |
Nield, Heidi |
|
dc.contributor.author |
Barton, Sheila J |
|
dc.contributor.author |
El-Heis, Sarah |
|
dc.contributor.author |
Tham, Elizabeth |
|
dc.contributor.author |
Godfrey, Keith M |
|
dc.contributor.author |
Chan, Shiao-Yng |
|
dc.contributor.author |
Cutfield, Wayne S |
|
dc.contributor.author |
NiPPeR Study Group |
|
dc.coverage.spatial |
England |
|
dc.date.accessioned |
2024-03-11T22:42:46Z |
|
dc.date.available |
2024-03-11T22:42:46Z |
|
dc.date.issued |
2024-01 |
|
dc.identifier.citation |
(2024). BMC Medicine, 22(1), 39-. |
|
dc.identifier.issn |
1741-7015 |
|
dc.identifier.uri |
https://hdl.handle.net/2292/67626 |
|
dc.description.abstract |
Background:
Nutritional intervention preconception and throughout pregnancy has been proposed as an approach to promoting healthy postnatal weight gain in the offspring but few randomised trials have examined this.
Methods:
Measurements of weight and length were obtained at multiple time points from birth to 2 years among 576 offspring of women randomised to receive preconception and antenatally either a supplement containing myo-inositol, probiotics, and additional micronutrients (intervention) or a standard micronutrient supplement (control). We examined the influence on age- and sex-standardised BMI at 2 years (WHO standards, adjusting for study site, sex, maternal parity, smoking and pre-pregnancy BMI, and gestational age), together with the change in weight, length, BMI from birth, and weight gain trajectories using latent class growth analysis.
Results:
At 2 years, there was a trend towards lower mean BMI among intervention offspring (adjusted mean difference [aMD] − 0.14 SD [95% CI 0.30, 0.02], p = 0.09), and fewer had a BMI > 95th percentile (i.e. > 1.65 SD, 9.2% vs 18.0%, adjusted risk ratio [aRR] 0.51 [95% CI 0.31, 0.82], p = 0.006). Longitudinal data revealed that intervention offspring had a 24% reduced risk of experiencing rapid weight gain > 0.67 SD in the first year of life (21.9% vs 31.1%, aRR 0.76 [95% CI 0.58, 1.00], p = 0.047). The risk was likewise decreased for sustained weight gain > 1.34 SD in the first 2 years of life (7.7% vs 17.1%, aRR 0.55 [95% CI 0.34, 0.88], p = 0.014). From five weight gain trajectories identified, there were more intervention offspring in the “normal” weight gain trajectory characterised by stable weight SDS around 0 SD from birth to 2 years (38.8% vs 30.1%, RR 1.29 [95% CI 1.03, 1.62], p = 0.029).
Conclusions:
Supplementation with myo-inositol, probiotics, and additional micronutrients preconception and in pregnancy reduced the incidence of rapid weight gain and obesity at 2 years among offspring. Previous reports suggest these effects will likely translate to health benefits, but longer-term follow-up is needed to evaluate this.
Trial registration:
ClinicalTrials.gov, NCT02509988 (Universal Trial Number U1111-1171–8056). Registered on 16 July 2015. |
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dc.format.medium |
Electronic |
|
dc.language |
eng |
|
dc.publisher |
Springer Nature |
|
dc.relation.ispartofseries |
BMC medicine |
|
dc.rights |
Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. |
|
dc.rights.uri |
https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm |
|
dc.rights.uri |
http://creativecommons.org/licenses/by/4.0/ |
|
dc.subject |
NiPPeR Study Group |
|
dc.subject |
Humans |
|
dc.subject |
Weight Gain |
|
dc.subject |
Inositol |
|
dc.subject |
Micronutrients |
|
dc.subject |
Body Mass Index |
|
dc.subject |
Pregnancy |
|
dc.subject |
Dietary Supplements |
|
dc.subject |
Probiotics |
|
dc.subject |
Female |
|
dc.subject |
Body-Weight Trajectory |
|
dc.subject |
Infant weight gain |
|
dc.subject |
Nutritional supplementation |
|
dc.subject |
Preconception |
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dc.subject |
Randomised trial |
|
dc.subject |
3215 Reproductive Medicine |
|
dc.subject |
32 Biomedical and Clinical Sciences |
|
dc.subject |
42 Health Sciences |
|
dc.subject |
Obesity |
|
dc.subject |
Prevention |
|
dc.subject |
Clinical Trials and Supportive Activities |
|
dc.subject |
Pediatric |
|
dc.subject |
Complementary and Integrative Health |
|
dc.subject |
Nutrition |
|
dc.subject |
Clinical Research |
|
dc.subject |
Reproductive health and childbirth |
|
dc.subject |
3 Good Health and Well Being |
|
dc.subject |
Science & Technology |
|
dc.subject |
Life Sciences & Biomedicine |
|
dc.subject |
Medicine, General & Internal |
|
dc.subject |
General & Internal Medicine |
|
dc.subject |
CHILDHOOD OBESITY |
|
dc.subject |
INSULIN-RESISTANCE |
|
dc.subject |
DOUBLE-BLIND |
|
dc.subject |
ADIPOSITY |
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dc.subject |
INFANCY |
|
dc.subject |
GROWTH |
|
dc.subject |
RISK |
|
dc.subject |
VITAMIN-B-12 |
|
dc.subject |
GLYCEMIA |
|
dc.subject |
11 Medical and Health Sciences |
|
dc.title |
Impact of preconception and antenatal supplementation with myo-inositol, probiotics, and micronutrients on offspring BMI and weight gain over the first 2 years |
|
dc.type |
Journal Article |
|
dc.identifier.doi |
10.1186/s12916-024-03246-w |
|
pubs.issue |
1 |
|
pubs.begin-page |
39 |
|
pubs.volume |
22 |
|
dc.date.updated |
2024-02-14T02:35:34Z |
|
dc.rights.holder |
Copyright: The authors |
en |
dc.identifier.pmid |
38287349 (pubmed) |
|
pubs.author-url |
https://bmcmedicine.biomedcentral.com/articles/10.1186/s12916-024-03246-w |
|
pubs.publication-status |
Published |
|
dc.rights.accessrights |
http://purl.org/eprint/accessRights/OpenAccess |
en |
pubs.subtype |
research-article |
|
pubs.subtype |
Journal Article |
|
pubs.elements-id |
1009253 |
|
pubs.org-id |
Liggins Institute |
|
pubs.org-id |
Medical and Health Sciences |
|
pubs.org-id |
Population Health |
|
pubs.org-id |
Gen.Practice& Primary Hlthcare |
|
pubs.org-id |
School of Medicine |
|
pubs.org-id |
Paediatrics Child & Youth Hlth |
|
dc.identifier.eissn |
1741-7015 |
|
dc.identifier.pii |
10.1186/s12916-024-03246-w |
|
pubs.number |
39 |
|
pubs.record-created-at-source-date |
2024-02-14 |
|
pubs.online-publication-date |
2024-01-30 |
|