dc.contributor.author |
Athavale, Omkar N |
|
dc.contributor.author |
Avci, Recep |
|
dc.contributor.author |
Clark, Alys R |
|
dc.contributor.author |
Di Natale, Madeleine R |
|
dc.contributor.author |
Wang, Xiaokai |
|
dc.contributor.author |
Furness, John B |
|
dc.contributor.author |
Liu, Zhongming |
|
dc.contributor.author |
Cheng, Leo K |
|
dc.contributor.author |
Du, Peng |
|
dc.coverage.spatial |
England |
|
dc.date.accessioned |
2024-03-12T23:43:29Z |
|
dc.date.available |
2024-03-12T23:43:29Z |
|
dc.date.issued |
2024-01 |
|
dc.identifier.citation |
(2024). Journal of Neural Engineering, 20(6), 066040-. |
|
dc.identifier.issn |
1741-2560 |
|
dc.identifier.uri |
https://hdl.handle.net/2292/67672 |
|
dc.description.abstract |
Objective. Neural regulation of gastric motility occurs partly through the regulation of gastric bioelectrical slow waves (SWs) and phasic contractions. The interaction of the tissues and organs involved in this regulatory process is complex. We sought to infer the relative importance of cellular mechanisms in inhibitory neural regulation of the stomach by enteric neurons and the interaction of inhibitory and excitatory electrical field stimulation. Approach. A novel mathematical model of gastric motility regulation by enteric neurons was developed and scenarios were simulated to determine the mechanisms through which enteric neural influence is exerted. This model was coupled to revised and extended electrophysiological models of gastric SWs and smooth muscle cells (SMCs). Main results. The mathematical model predicted that regulation of contractile apparatus sensitivity to intracellular calcium in the SMC was the major inhibition mechanism of active tension development, and that the effect on SW amplitude depended on the inhibition of non-specific cation currents more than the inhibition of calcium-activated chloride current (kiNSCC = 0.77 vs kiAno1 = 0.33). The model predicted that the interaction between inhibitory and excitatory neural regulation, when applied with simultaneous and equal intensity, resulted in an inhibition of contraction amplitude almost equivalent to that of inhibitory stimulation (79% vs 77% decrease), while the effect on frequency was overall excitatory, though less than excitatory stimulation alone (66% vs 47% increase). Significance. The mathematical model predicts the effects of inhibitory and excitatory enteric neural stimulation on gastric motility function, as well as the effects when inhibitory and excitatory enteric neural stimulation interact. Incorporation of the model into organ-level simulations will provide insights regarding pathological mechanisms that underpin gastric functional disorders, and allow for in silico testing of the effects of clinical neuromodulation protocols for the treatment of these disorders. |
|
dc.format.medium |
Electronic |
|
dc.language |
eng |
|
dc.publisher |
IOP Publishing |
|
dc.relation.ispartofseries |
Journal of neural engineering |
|
dc.rights |
Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. |
|
dc.rights.uri |
https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm |
|
dc.rights.uri |
https://creativecommons.org/licenses/by/4.0/ |
|
dc.subject |
Stomach |
|
dc.subject |
Neurons |
|
dc.subject |
Myocytes, Smooth Muscle |
|
dc.subject |
Calcium |
|
dc.subject |
Muscle Contraction |
|
dc.subject |
autonomic neuroscience |
|
dc.subject |
gastric electrophysiology |
|
dc.subject |
gastric motility |
|
dc.subject |
mathematical modelling |
|
dc.subject |
3208 Medical Physiology |
|
dc.subject |
32 Biomedical and Clinical Sciences |
|
dc.subject |
Digestive Diseases |
|
dc.subject |
Neurosciences |
|
dc.subject |
Bioengineering |
|
dc.subject |
1 Underpinning research |
|
dc.subject |
1.1 Normal biological development and functioning |
|
dc.subject |
Science & Technology |
|
dc.subject |
Technology |
|
dc.subject |
Life Sciences & Biomedicine |
|
dc.subject |
Engineering, Biomedical |
|
dc.subject |
Engineering |
|
dc.subject |
Neurosciences & Neurology |
|
dc.subject |
GASTRIC SMOOTH-MUSCLE |
|
dc.subject |
INTRAMUSCULAR INTERSTITIAL-CELLS |
|
dc.subject |
CA2+-ACTIVATED K+ CHANNEL |
|
dc.subject |
NITRIC-OXIDE |
|
dc.subject |
JUNCTION POTENTIALS |
|
dc.subject |
PACEMAKER ACTIVITY |
|
dc.subject |
CA2+ SENSITIVITY |
|
dc.subject |
CIRCULAR MUSCLE |
|
dc.subject |
MOTOR-ACTIVITY |
|
dc.subject |
CAJAL |
|
dc.subject |
0903 Biomedical Engineering |
|
dc.subject |
1103 Clinical Sciences |
|
dc.subject |
1109 Neurosciences |
|
dc.subject |
3209 Neurosciences |
|
dc.subject |
4003 Biomedical engineering |
|
dc.title |
Neural regulation of slow waves and phasic contractions in the distal stomach: a mathematical model |
|
dc.type |
Journal Article |
|
dc.identifier.doi |
10.1088/1741-2552/ad1610 |
|
pubs.issue |
6 |
|
pubs.begin-page |
066040 |
|
pubs.volume |
20 |
|
dc.date.updated |
2024-02-13T13:28:49Z |
|
dc.rights.holder |
Copyright: The authors |
en |
dc.identifier.pmid |
38100816 (pubmed) |
|
pubs.author-url |
https://iopscience.iop.org/article/10.1088/1741-2552/ad1610 |
|
pubs.publication-status |
Published |
|
dc.rights.accessrights |
http://purl.org/eprint/accessRights/OpenAccess |
en |
pubs.subtype |
research-article |
|
pubs.subtype |
Journal Article |
|
pubs.subtype |
Research Support, N.I.H., Extramural |
|
pubs.elements-id |
1004207 |
|
pubs.org-id |
Bioengineering Institute |
|
pubs.org-id |
ABI Associates |
|
dc.identifier.eissn |
1741-2552 |
|
pubs.number |
ARTN 066040 |
|
pubs.record-created-at-source-date |
2024-02-14 |
|
pubs.online-publication-date |
2024-01-04 |
|